1978
DOI: 10.1016/0042-6822(78)90430-0
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Particle heterogeneity in vaccinia virus populations during passage

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Cited by 4 publications
(2 citation statements)
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“…It has long been recognized that vaccinia virus represents a heterogeneous swarm of virus subpopulations that differ biologically and molecularly. 11 This variation became especially important as vaccinia was developed as a live vector for foreign genes. Plaque-purified vaccinia virus lines were shown to differ significantly in neurovirulence for mice, in their ability to evoke immune responses against the inserted gene product, and in their HindIII restriction maps.…”
Section: Discussionmentioning
confidence: 99%
“…It has long been recognized that vaccinia virus represents a heterogeneous swarm of virus subpopulations that differ biologically and molecularly. 11 This variation became especially important as vaccinia was developed as a live vector for foreign genes. Plaque-purified vaccinia virus lines were shown to differ significantly in neurovirulence for mice, in their ability to evoke immune responses against the inserted gene product, and in their HindIII restriction maps.…”
Section: Discussionmentioning
confidence: 99%
“…The host range mutants were interpreted to be defective in some control function required for virus replication (8). Subsequent genomic analysis of these rabbitpox virus mutants (18,25) demonstrated extensive terminal deletions (up to 30 kilobases [kb]) of DNA. Host range mutants of vaccinia virus have also been described (4, 5,10,15,22,39). Nitrous acid mutagenesis of the Copenhagen strain of vaccinia virus allowed Drillien et al (4) to isolate a host range mutant defective in replication in most human cells.…”
mentioning
confidence: 99%