1981
DOI: 10.1016/0042-6822(81)90351-2
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Host range deletion mutant of vaccinia virus defective in human cells

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Cited by 90 publications
(61 citation statements)
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“…The isolation of VV host range mutants which are unable to multiply in some cell types has suggested that viral functions are involved in determining such a wide host range. One mutant isolated in our laboratory from the Copenhagen strain, designated VV hr, has 18 kbp deleted near the left end of the genome (Drillien et al, 1981). Similar mutants have been isolated by multiple passages of the CVA strain on chick embryo fibroblasts (Mayr et al, 1975;Altenburger et al, 1989;Meyer et al, 1991) or by directed deletion of VV sequences using recombinant plasmids (Perkus et al, 1991).…”
mentioning
confidence: 99%
“…The isolation of VV host range mutants which are unable to multiply in some cell types has suggested that viral functions are involved in determining such a wide host range. One mutant isolated in our laboratory from the Copenhagen strain, designated VV hr, has 18 kbp deleted near the left end of the genome (Drillien et al, 1981). Similar mutants have been isolated by multiple passages of the CVA strain on chick embryo fibroblasts (Mayr et al, 1975;Altenburger et al, 1989;Meyer et al, 1991) or by directed deletion of VV sequences using recombinant plasmids (Perkus et al, 1991).…”
mentioning
confidence: 99%
“…This is in contrast to the near-terminal regions of poxvirus genomes which are quite dissimilar with limited conservation between members of a given genus, but little conservation between genera Upton et al, 1987a). There is evidence that located within these regions is much of the genetic material involved in pathogenicity and host range specificity (Bloom et al, 1991 ;Drillien et al, 1981 ;Gillard et al, 1986;Spehner et al, 1988). The complete genome of vaccinia virus has been sequenced and near-terminal-encoded products include viral homologues of epidermal growth factor (Blomquist et al, 1984;Brown et al, 1985;Reisner, 1985), serine protease inhibitors (serpins) , protein kinase Traktman et al, 1989), a dUTPase-like gene (McGeoch, 1990;Slabaugh & Roseman, 1989) and complement control protein analogues (Kotwal & Moss, 1988a;Takahashi-Nishimaki et al, 1991).…”
Section: Introductionmentioning
confidence: 89%
“…It has been shown previously that the production of epitopes can differ in different cell types (51). Vaccinia viruses have a very broad replication capability in different human cells (52), but because MVA is replication defective in human cells (53), the primary target cells after intradermal application might be skin fibroblasts (53) and to some degree skin dendritic cells (53,54). In contrast, the immunodeficiency viruses replicate mostly in CD4 ϩ cells (55)(56)(57)(58)(59).…”
Section: Discussionmentioning
confidence: 99%