Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein

Spriggs, Melanie K.; Hruby, Dennis E.; Maliszewski, C R; Pickup, David J.; Sims, John E.; Buller, R. Mark; VanSlyke, Judy K.

doi:10.1016/0092-8674(92)90273-f

Cited by 309 publications

(158 citation statements)

References 35 publications

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“…Thus, it is surprising that expression of soluble cytokine receptors is a common feature of the poxviruses [133]. Poxviruses such as vaccinia, cowpox, myxoma viruses, and Shope fibroma virus express soluble receptor homologues that include receptors for TNF, interferon (IFN)-␥, and IL-1 [134][135][136][137]. Several pox viruses, in fact, express more than one soluble receptor.…”

Section: Viral Soluble Receptorsmentioning

confidence: 99%

Soluble receptors in human disease

Heaney

Golde

1998

Journal of Leukocyte Biology

154

132

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Section: Viral Soluble Receptorsmentioning

confidence: 99%

Soluble receptors in human disease

Heaney

Golde

1998

Journal of Leukocyte Biology

154

132

View full text Add to dashboard Cite

“…4b). Among a battery of IL-1R related proteins reported, a product of vaccinia virus has recently been shown to be a soluble IL-1R [7,8]. Other soluble IL-l binding proteins remain to be studied [9,10].…”

Section: Febslettersmentioning

confidence: 99%

Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1

et al. 1993

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In the course of studying the ST2 gene, which was initially found to be expressed specifically at the C&G, transitional state in BALBlc-3T3 cells and was one of the primary response genes, we found another ST2-related mRNA, designated as STZL, in serum-stimulated BALB/c-3T3 cells in the presence of cycloheximide. Nucleotide sequence analysis of the cloned STZL cDNA revealed that it had an open reading frame encoding a polypeptide of 567 amino acids. A 5' region (1,028 nucleotides) of STZL cDNA was identical with the ST2 cDNA, and a unique 3' region encoded 'a putative transmembrane domain of 24 amino acids and a cytoplasmic domain of 201 amino acids. The ST2 gene product is highly similar to the extracellular portion of IL-I receptors type 1 and type 2, and the STZL gene product shows a marked similarity with entire IL-l receptor type I.

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“…A smart poxviral strategy to evade the antiviral defense is to encode soluble proteins that prevent the binding of cytokines to their cognate cellular receptors. Poxviral cytokine-binding proteins with specificity for mammalian tumor necrosis factor-␣ and -␤ (9 -12), interleukin-1␤ (IL-1␤) 1 (13)(14)(15), IL-2 (16), IL-18 (17)(18)(19), interferon (IFN)-␣/␤ (20,21), IFN-␥ (22,23), granulocyte macrophage colony-stimulating factor (16), and various chemokines (24 -26) were identified. The importance of IFN-␥ in host defense against poxvirus infections was clearly demonstrated in both tissue culture and animal model systems (27,28).…”

mentioning

confidence: 99%