An Interferon-γ-binding Protein of Novel Structure Encoded by the Fowlpox Virus

Puehler, Florian; Schwarz, Heike; Waidner, Barbara; Kalinowski, Joern; Kaspers, Bernd; Bereswill, Stefan; Staeheli, Peter

doi:10.1074/jbc.m207336200

Cited by 25 publications

(13 citation statements)

References 55 publications

(52 reference statements)

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“…These include, for example, ankyrin repeat proteins, C-type lectins, immunoglobulin domain genes, and members of the N1R/p28 family (24). Furthermore, FP9 still possesses IFN-␥-binding (37) and putative interleukin 18-binding proteins, as well as chemokine-like proteins (21). The interpretation is hindered by incomplete understanding of the avian immune system, quite apart from the more complex question of the function of avian viral immunomodulators in a xenologous host.…”

Section: Discussionmentioning

confidence: 99%

Different Levels of Immunogenicity of Two Strains of Fowlpox Virus as Recombinant Vaccine Vectors Eliciting T-Cell Responses in Heterologous Prime-Boost Vaccination Strategies

Cottingham

Maurik

Zago

et al. 2006

Clin Vaccine Immunol

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Section: Discussionmentioning

confidence: 99%

Different Levels of Immunogenicity of Two Strains of Fowlpox Virus as Recombinant Vaccine Vectors Eliciting T-Cell Responses in Heterologous Prime-Boost Vaccination Strategies

Cottingham

Maurik

Zago

et al. 2006

Clin Vaccine Immunol

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“…Consequently, we hypothesize that following immunization, FWPV directly infects pDCs and drives inflammasome assembly by the cytosolic recognition of FWPV OVA -derived dsDNA, putatively via AIM2 (57), which in turn triggers the release of active IL-18, thus facilitating T-cell adaptive immune responses to FWPV-encoded antigens. It has been postulated that IL-18 signaling within T cells subsequently drives the T-cell-intrinsic secretion of IFN-␥, which would explain why IFN-␥ secretion is actively targeted by immunomodulatory genes of many members of the poxvirus family (51,54,59). Furthermore, we propose that this immune response occurs even in the absence of the TLR-meditated innate immune recognition of rFWPV, because FWPV infection enables inflammasome activation and the release of preformed pro-IL-18 from pDCs and results in MyD88-dependent signaling through the T cell's IL-18R (61).…”

Section: Vol 85 2011mentioning

confidence: 99%

Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition

Lousberg

Diener

Fraser

et al. 2011

J Virol

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Fowlpox virus (FWPV) is a double-stranded DNA virus long used as a live-attenuated vaccine against poultry diseases, but more recent interest has focused on its use as a mammalian vaccine vector. Here, in a mouse model system using FWPV encoding the nominal target antigen chicken ovalbumin (OVA) (FWPV OVA ), we describe for the first time some of the fundamental processes by which FWPV engages both the innate and adaptive immune systems. We show that Toll-like receptor 7 (TLR7) and TLR9 are important for type I interferon secretion by dendritic cells, while TLR9 is solely required for proinflammatory cytokine secretion. Despite this functional role for TLR7 and TLR9 in vitro, only the adapter protein myeloid differentiation primary response gene 88 (MyD88) was shown to be essential for the formation of adaptive immunity to FWPV OVA in vivo. The dependence on MyD88 was confined only to the T-cell compartment and was not related to its contribution to TLR signaling, dendritic cell maturation, or the capture and presentation of FWPVderived OVA antigen. We demonstrate that this is not by means of mediating T-cell-dependent interleukin-1 (IL-1) signaling, but rather, we suggest that MyD88 functions to support T-cell-specific IL-18 receptor signaling, which in turn is essential for the formation of adaptive immunity to FWPV-encoded OVA.

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“…Thus, the complete lack of genes predicted to involve manipulation of host immune responses in CRV is striking. As is the case with other poxviruses encoding novel proteins affecting host immune and apoptotic responses (29,47,96,127), it is likely that many of the novel genes present in CRV encode proteins capable of affecting similar host responses.…”

mentioning

confidence: 99%

Genome of Crocodilepox Virus

Afonso

Tulman

Delhon

et al. 2006

J Virol

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Here, we present the genome sequence, with analysis, of a poxvirus infecting Nile crocodiles (Crocodylus niloticus) (crocodilepox virus; CRV). The genome is 190,054 bp (62% G؉C) and predicted to contain 173 genes encoding proteins of 53 to 1,941 amino acids. The central genomic region contains genes conserved and generally colinear with those of other chordopoxviruses (ChPVs). CRV is distinct, as the terminal 33-kbp (left) and 13-kbp (right) genomic regions are largely CRV specific, containing 48 unique genes which lack similarity to other poxvirus genes. Notably, CRV also contains 14 unique genes which disrupt ChPV gene colinearity within the central genomic region, including 7 genes encoding GyrB-like ATPase domains similar to those in cellular type IIA DNA topoisomerases, suggestive of novel ATP-dependent functions. The presence of 10 CRV proteins with similarity to components of cellular multisubunit E3 ubiquitin-protein ligase complexes, including 9 proteins containing F-box motifs and F-box-associated regions and a homologue of cellular anaphasepromoting complex subunit 11 (Apc11), suggests that modification of host ubiquitination pathways may be significant for CRV-host cell interaction. CRV encodes a novel complement of proteins potentially involved in DNA replication, including a NAD ؉ -dependent DNA ligase and a protein with similarity to both vaccinia virus F16L and prokaryotic serine site-specific resolvase-invertases. CRV lacks genes encoding proteins for nucleotide metabolism. CRV shares notable genomic similarities with molluscum contagiosum virus, including genes found only in these two viruses. Phylogenetic analysis indicates that CRV is quite distinct from other ChPVs, representing a new genus within the subfamily Chordopoxvirinae, and it lacks recognizable homologues of most ChPV genes involved in virulence and host range, including those involving interferon response, intracellular signaling, and host immune response modulation. These data reveal the unique nature of CRV and suggest mechanisms of virus-reptile host interaction.

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An Interferon-γ-binding Protein of Novel Structure Encoded by the Fowlpox Virus

Cited by 25 publications

References 55 publications

Different Levels of Immunogenicity of Two Strains of Fowlpox Virus as Recombinant Vaccine Vectors Eliciting T-Cell Responses in Heterologous Prime-Boost Vaccination Strategies

Different Levels of Immunogenicity of Two Strains of Fowlpox Virus as Recombinant Vaccine Vectors Eliciting T-Cell Responses in Heterologous Prime-Boost Vaccination Strategies

Antigen-Specific T-Cell Responses to a Recombinant Fowlpox Virus Are Dependent on MyD88 and Interleukin-18 and Independent of Toll-Like Receptor 7 (TLR7)- and TLR9-Mediated Innate Immune Recognition

Genome of Crocodilepox Virus

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