Vaccines for fish in aquaculture

Sommerset, Ingunn; Krossøy, Bjørn; Biering, Eirik; Frost, Petter

doi:10.1586/14760584.4.1.89

Cited by 599 publications

(449 citation statements)

References 58 publications

Supporting

Mentioning

407

Contrasting

Unclassified

Order By: Relevance

“…In this scenario, controlling disease outbreaks by vaccination and the use of immune modulator enriched diets represents a major achievement for aquaculture species. Although fish vaccination is still crawling, it has been successfully used to control important fish diseases (Sommerset et al 2005, Secombes 2008, Van Muiswinkel 2008, Plant & Lapatra 2011. And, more recently, vaccination commingled with the inclusion of immune-modulator molecules in the diet offered and additional strategy to overcome major pathogen (Newaj-Fyzul & Austin 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Although antibiotics have been widely used for disease treatment, mainly in fries and fingerlings (Brudeseth et al 2013), the surge of antibiotics-resistant bacteria, and antibiotics residues in water and meat, raised major concerns towards this management procedure. In this scenario, strengthening the fish defense mechanisms by vaccination to specific pathogens or by adding immune modulating molecules in the diet has been increasingly explored as an economically viable procedure to prevent disease outbreaks (Bricknell & Dalmo 2005, Sommerset et al 2005, Plant & Laptra 2011, Bairwa et al 2012.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

View full text Add to dashboard Cite

RESUMO.-[Efeito imunomodulador da β-glucana usada como aditivo alimentar em jundiás (Rhamdia quelen).]O uso da β-glucana como suplemento alimentar foi avaliado em jundiás. A β-glucana foi adicionada à ração na proporção de 0.01%, e 0.1% e fornecida aos peixes por 21, para avaliar dados hematológicos e parâmetros do sistema imune natural, ou 42 dias, para avaliar ganho de peso e resistência ao desafio com Aeromonas hydrophila. A adição da β-glucana na dieta não afetou o ganho de peso e não induziu alterações hematológicas nem alterações nos níveis de aglutininas e mieloperoxidase sanguínea. No entanto, a atividade hemolítica natural do sistema do complemento foi significativamente maior nos peixes alimentados com β-glucana. Além disso, nos peixes alimentados com β-glucana e desafiados com A. hydrophila, o número de bactérias isoladas do sangue foi significativamente menor, e a sobrevivência ao desafio foi significativamente maior do que nos peixes que não receberam β-glucana. Consequentemente, concluímos que a β-glucana tem potencial imunomodulador quando adicionada à dieta, nas condições experimentais aqui indicadas, e contribui para aumentar imunidade natural e a resistência dos jundiás ao desafio com patógenos específicos. INTRODUCTIONThe occurrence of infectious diseases is one of the major causes of losses in modern aquaculture (Sitjà-Bobadilla The immunomodulatory effects of dietary β-glucan were evaluated in silver catfish. β-glucan was added to the diet (0.01%, and 0.1%) and fed to the fish for 21 days, to evaluate effects on blood and some innate immune parameter, or fed for 42 days, to evaluate growth rate and resistance to challenge with pathogenic Aeromonas hydrophila. We found that adding β-glucan to the diet had no effect on fish growth and no effect on blood cells, or serum bacterial agglutination and serum myeloperoxidase activity. However, fish that received β-glucan in the diet had the natural hemolytic activity of complement significantly higher compared to control fish. Furthermore, fish fed with β-glucan and challenged with A. hydrophila had fewer bacteria in blood and presented a significantly higher survival rate compared to control fish. Thus, we concluded that β-glucan might be explored as feed additive aiming to improve silver catfish innate immunity and resistance to specific pathogen.INDEX TERMS: Silver catfish, Rhamdia quelen, fish, immunostimulants, β-glucan, Aeromonas hydrophila.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of dietary β-glucan in silver catfish (Rhamdia quelen)

Domenico

Canova²,

Soveral³

et al. 2017

Pesq. Vet. Bras.

View full text Add to dashboard Cite

show abstract

“…However, risk of antibiotic resistance development and the associated health risk have led to a search for sustainable alternatives (Skjermo and Vadstein, 1999; Sommerset et al ., 2005; Defoirdt et al ., 2011). The deployment of vaccines has limited the use of antibiotics especially in Europe and North America (Defoirdt et al ., 2011; Ringø et al ., 2014).…”

Section: Introductionmentioning

confidence: 99%

“…The deployment of vaccines has limited the use of antibiotics especially in Europe and North America (Defoirdt et al ., 2011; Ringø et al ., 2014). However, antibiotics are still used in many countries and fish larviculture as their undeveloped immune system does not allow for vaccination (Sommerset et al ., 2005; Defoirdt et al ., 2011). An alternative to antibiotics in such systems is probiotics, that is live microorganisms which exert beneficial effects on the host health (FAO and WHO, 2001), for example by inhibiting growth of pathogenic bacteria (Gatesoupe, 1999; Skjermo and Vadstein, 1999; Kesarcodi‐Watson et al ., 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of TDA‐producing Phaeobacter inhibens on the fish pathogen Vibrio anguillarum in non‐axenic algae and copepod systems

Rasmussen

Erner

Bentzon-Tilia

et al. 2018

Microbial Biotechnology

View full text Add to dashboard Cite

SummaryThe expanding aquaculture industry plays an important role in feeding the growing human population and with the expansion, sustainable bacterial disease control, such as probiotics, becomes increasingly important. Tropodithietic acid (TDA)‐producing Phaeobacter spp. can protect live feed, for example rotifers and Artemia as well as larvae of turbot and cod against pathogenic vibrios. Here, we show that the emerging live feed, copepods, is unaffected by colonization of the fish pathogen Vibrio anguillarum, making them potential infection vectors. However, TDA‐producing Phaeobacter inhibens was able to significantly inhibit V. anguillarum in non‐axenic cultures of copepod Acartia tonsa and the copepod feed Rhodomonas salina. Vibrio grew to 106 CFU ml−1 and 107 CFU ml−1 in copepod and R. salina cultures, respectively. However, vibrio counts remained at the inoculum level (104 CFU ml−1) when P. inhibens was also added. We further developed a semi‐strain‐specific qPCR for V. anguillarum to detect and quantify the pathogen in non‐axenic systems. In conclusion, P. inhibens efficiently inhibits the fish larval pathogen V. anguillarum in the emerging live feed, copepods, supporting its use as a probiotic in aquaculture. Furthermore, qPCR provides an effective method for detecting vibrio pathogens in complex non‐axenic live feed systems.

show abstract

“…Currently, vaccines are available for many economically important bacterial and viral diseases, that have proven to be efficacious in fish (Sommerset et al, 2005;Muktar et al, 2016).…”

mentioning

confidence: 99%