Vaccines Against Vector-Borne Diseases

Kitsou, Chrysoula; Pal, Utpal

doi:10.1007/978-1-0716-1888-2_16

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Disease burden is exacerbated by limited access and the non-presentation of many patients to any health-care provider, as well as lack of effective control measures [ 5 ]. Despite increasing awareness about ticks as serious disease vectors, effective vaccines against most tick-borne infections are not available [ 39 ]. In addition, Pakistan's healthcare system lacks the resources and expertise to perform research into the development of effective vaccines, which is another obstacle in safeguarding the vulnerable population [ 32 ].…”

Section: Challenges Aggravating the Vbd Situationmentioning

confidence: 99%

The impact of COVID-19 followed by extreme flooding on vector borne diseases in Pakistan: A mini narrative review

Rahmat

Sadiq

Vohra

et al. 2023

New Microbes and New Infections

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Section: Challenges Aggravating the Vbd Situationmentioning

confidence: 99%

The impact of COVID-19 followed by extreme flooding on vector borne diseases in Pakistan: A mini narrative review

Rahmat

Sadiq

Vohra

et al. 2023

New Microbes and New Infections

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“…Vector-borne diseases pose a major threat to public health and agricultural systems globally ( Institute of Medicine (US) Forum on Microbial Threats 2008 , Golding et al 2015 , Kitsou and Pal 2022 ). These systems are typically complex and span multiple spatial and temporal scales.…”

mentioning

confidence: 99%

Characterizing the Vector Data Ecosystem

Lippi

Rund

Ryan

2023

Journal of Medical Entomology

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A growing body of information on vector-borne diseases has arisen as increasing research focus has been directed towards the need for anticipating risk, optimizing surveillance, and understanding the fundamental biology of vector-borne diseases to direct control and mitigation efforts. The scope and scale of this information, in the form of data, comprising database efforts, data storage, and serving approaches, means that it is distributed across many formats and data types. Data ranges from collections records to molecular characterization, geospatial data to interactions of vectors and traits, infection experiments to field trials. New initiatives arise, often spanning the effort traditionally siloed in specific research disciplines, and other efforts wane, perhaps in response to funding declines, different research directions, or lack of sustained interest. Thusly, the world of vector data – the Vector Data Ecosystem – can become unclear in scope, and the flows of data through these various efforts can become stymied by obsolescence, or simply by gaps in access and interoperability. As increasing attention is paid to creating FAIR (Findable Accessible Interoperable, and Reusable) data, simply characterizing what is ‘out there’, and how these existing data aggregation and collection efforts interact, or interoperate with each other, is a useful exercise. This study presents a snapshot of current vector data efforts, reporting on level of accessibility, and commenting on interoperability using an illustration to track a specimen through the data ecosystem to understand where it occurs for the database efforts anticipated to describe it (or parts of its extended specimen data).

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Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling

Scott,

Smith,

Heeren

et al. 2023

mSystems

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Spatially aware de novo discovery methods are essential tools for therapeutic target identification in complex interphylum interactions such as arthropods and mammals. Notably, the methods should ideally be species agnostic, showing unique features of all interacting species. We evaluated the possibilities for matrix-assisted desorption/ionization mass spectrometry imaging (MALDI-MSI, referred to here as MSI) as a spatial “omics” method to simultaneously profile both an arthropod vector ( Ixodes tick) and a mammalian skin (guinea pig) in a bite model. We demonstrated the feasibility of MSI using gelatin-stabilized sample mounting that allowed for serial sectioning and mapping lipids in control and bitten skin, including the tick body and embedded mouthparts. We identified unique lipid ion patterns and observed lipid reorganization beneath the bite site consistent with histological changes. Furthermore, several ions were observed in the tick body with lower intensity in the dermis and control skin, suggesting the transmission of lipids from the tick to mammalian skin. These results establish a multi-system approach for discovering cross-species molecular interactions that can be further developed as targets to disrupt the vector-host interface. IMPORTANCE Here, we demonstrate the adaptability of spatial “omics” methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between hosts, arthropod vectors and transmitted pathogens, and contributes toward the development of spatially aware therapeutic target discovery and description.

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Vaccines Against Vector-Borne Diseases

Cited by 5 publications

References 11 publications

The impact of COVID-19 followed by extreme flooding on vector borne diseases in Pakistan: A mini narrative review

The impact of COVID-19 followed by extreme flooding on vector borne diseases in Pakistan: A mini narrative review

Characterizing the Vector Data Ecosystem

Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling

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