Vaccine efficacy of recombinant feline herpesvirus type 1 expressing immunogenic proteins of feline calicivirus in cats

Yokoyama, Naoki; Maeda, Ken; Fujita, Kentaro; Ishiguro, S.; Sagawa, Teiri; Mochizuki, Masahito; Tohya, Yukinobu; Mikami, Takeshi

doi:10.1007/bf01718635

Cited by 15 publications

(17 citation statements)

References 31 publications

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“…Thus recombinant poxviruses and baculoviruses have been constructed expressing the FeHV-1 glycoprotein D to characterize its properties and potential as an immunogen [77,120]. A number of FeHV-1 deletion/insertional mutants have been developed including thymidine kinase deletion mutants, some of which have incorporated other genes including the FCV capsid gene [12,88,89,144,[156][157][158][159]; gE-gI deletion mutants [68,129,130]; a gI insertional mutant (which also appeared to affect the transcription pattern and expression of the upstream gene gD) [150,151]; and an insertional mutant of 'ORF2', downstream of glycoprotein C [149]. In general, these deletion/insertional mutants are less virulent for cats and offer some protection against disease, especially via the oro-nasal route.…”

Section: Vaccinationmentioning

confidence: 99%

Feline herpesvirus

et al. 2007

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Section: Vaccinationmentioning

confidence: 99%

Feline herpesvirus

et al. 2007

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“…Herpes simplex virus (HSV) was utilized as a gene delivery vector in the model experiments of gene therapy [9 and others]. Yokoyama et al [35] constructed a recombinant feline herpesvirus 1 (FHV-1) expressing immunogenic proteins of feline calicivirus. The fusion and hemagglutinin neuraminidase antigens of Newcastle disease virus were inserted in the genome of turkey herpesvirus (HVT) [7].…”

Section: Viruses and Cellsmentioning

confidence: 99%

Characterization of Promoters Integrated in the Genome of Bovine Herpesvirus-1(BHV-1).

Murata

Xuan

Otsuka

1999

The Journal of Veterinary Medical Science

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ABSTRACT. Bovine herpesvirus-1 (BHV-1) has been used as a vector of live recombinant vaccines for cattle which express the genes of other pathogens. Because of the importance of the choice of the promoter which allows the efficient expression of the foreign genes in the BHV-1 vector, we compared the relative efficacy of various promoters integrated in the BHV-1 genome. The promoter sequences of the BHV-1 thymidine kinase (tk), gB, gC, SV40 early, and pseudorabies virus (PRV) immediate early (IE) genes were placed at the upstream of the open reading frame of the chloramphenycol acetyl transferase (CAT) gene and the promoter-CAT sequences were integrated into the tk gene of BHV-1 by homologous recombination. The promoter activity was assayed by measuring the CAT activity in the extracts of Madin Darby bovine kidney (MDBK) cells infected with the recombinant BHV-1. The PRV IE promoter was activated earlier and maintained at a higher level activity than the BHV-1 gB or gC promoters throughout the most of the growth phase of BHV-1. At the late phase, however, the activities of the BHV-1 gB and gC promoters reached the higher level. The BHV-1 tk promoter activity was low and the SV40 early promoter was hardly activated when integrated into the BHV-1 genome.-KEY WORDS: CAT assay, gene expression, promoter, recombinant BHV-1.

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“…FCV immunogenic antigens were expressed mainly as a fusion capsid protein with the Nterminal part of TK under the control of the FHV-1 TK promoter by the recombinant FHV-1 [132]. In vivo experiments to assess the vaccine efficacy of the recombinant FHV-1 against FCV and FHV-1 infections in cats revealed that two vaccinations of the recombinant FHV-1 by the intraocular, intranasal, and oral routes protected cats to a significant degree against subsequent virulent challenges with both parent FCV and FHV-1 strains [133].…”

Section: ) Expression Of Fcv Antigensmentioning

confidence: 99%

Recombinant Viral Vector Vaccines for the Veterinary Use.

Yokoyama

Maeda

Mikami

1997

The Journal of Veterinary Medical Science

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ABSTRACT. Recently, genetically engineering using recombinant DNA techniques has been applied to design new viral vaccines in order to reduce some problems which present viral vaccines have. Up to now, many viruses have been investigated for development of recombinant attenuated vaccines or live viral vectors for delivery of foreign immunogenic antigens. In this review, we introduced three kind of viruses; herpesviruses, vaccinia viruses, and adenoviruses, which have best widely been studied as recombinant vaccines or delivery vaccines for the veterinary use. -KEY WORDS: recombinant polyvalent vaccine, recombinant vaccine, viral vector.

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Vaccine efficacy of recombinant feline herpesvirus type 1 expressing immunogenic proteins of feline calicivirus in cats

Cited by 15 publications

References 31 publications

Feline herpesvirus

Feline herpesvirus

Characterization of Promoters Integrated in the Genome of Bovine Herpesvirus-1(BHV-1).

Recombinant Viral Vector Vaccines for the Veterinary Use.

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