Vaccination of domestic animals against tuberculosis: Review of progress and contributions to the field of the TBSTEP project

Vordermeier, H. Martin; Val, Bernat Pérez de; Buddle, Bryce M.; Villarreal‐Ramos, Bernardo; Jones, Gareth; Hewinson, R. Glyn; Domingo, Mariano

doi:10.1016/j.rvsc.2014.04.015

Cited by 27 publications

(21 citation statements)

References 73 publications

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“…caprae infection induced higher IFN-γ levels either to ESAT-6/CFP-10 or PC-EC and PC-HP peptide cocktails in unvaccinated and HIMB vaccinated animals compared to the BCG group, this being consistent with the vaccination outcome assessed as volume of gross lesions and bacterial load. The association of protection with reduced levels of systemic IFN-γ responses to growth-related mycobacterial antigens was also observed in a number of TB vaccine trials conducted in cattle and goats [17]. All animals responded to the DIVA-based antigen formulations (ESAT-6/CFP-10, PC-EC and PC-HP) after challenge, whereas none of the BCG vaccinated animals responded to these antigens after vaccination, confirming its usefulness for DIVA-based diagnosis [16, 17].…”

Section: Discussionmentioning

confidence: 73%

“…The association of protection with reduced levels of systemic IFN-γ responses to growth-related mycobacterial antigens was also observed in a number of TB vaccine trials conducted in cattle and goats [17]. All animals responded to the DIVA-based antigen formulations (ESAT-6/CFP-10, PC-EC and PC-HP) after challenge, whereas none of the BCG vaccinated animals responded to these antigens after vaccination, confirming its usefulness for DIVA-based diagnosis [16, 17]. In addition, none of the HIMB vaccinated lambs responded to DIVA antigens prior to challenge.…”

Section: Discussionmentioning

confidence: 73%

“…gross pathology and bacterial load). Ex vivo ESAT-6, ESAT-6-CFP-10 or PPD-B specific IFN-γ responses were previously identified as correlates of disease severity in experimentally infected cattle and goats [17, 21, 32]. …”

Section: Discussionmentioning

confidence: 99%

“…The rationale is the lack of availability of diagnostic tests to differentiate vaccinated from infected animals (DIVA tests) [2]. In countries where test and cull control strategies are ongoing, DIVA tests would be necessary if, vaccination with BCG or other mycobacterial based vaccines were applied [17]. Moreover, regarding wildlife oral vaccination, the safety of baits on non-target species must be also considered [2].…”

Section: Introductionmentioning

confidence: 99%

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Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

et al. 2017

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Background/AimsAnimal tuberculosis (TB) is a complex animal health problem that causes disruption to trade and significant economic losses. TB involves a multi-host system where sheep, traditionally considered a rare host of this infection, have been recently included. The aims of this study were to develop an experimental TB infection model in sheep with a Mycobacterium caprae field strain isolated from a tuberculous diseased ewe, and to use this to evaluate the safety and efficacy of two vaccines against TB in sheep, the live-attenuated M. bovis BCG vaccine (Danish strain) and a heat-inactivated M. bovis (HIMB) vaccine.MethodsEighteen 2 month-old lambs were experimentally challenged with M. caprae by the endotracheal route (1.5 × 103 CFU). They were separated per treatment group into parenterally vaccinated with a live BCG Danish strain vaccine (n = 6), orally vaccinated with a suspension of HIMB (n = 6) and unvaccinated controls (n = 6). Clinical, immunological, pathological and bacteriological parameters of infection were measured.ResultsAll lambs were successfully infected and developed gross TB lesions in the respiratory system. The BCG vaccine conferred considerable protection against experimental TB in lambs, as measured by a reduction of the gross lesion volumes and bacterial load. However, HIMB vaccinated animals did not show protection.ConclusionsThis study proposes a reliable new experimental model for a better understanding of tuberculosis in sheep. BCG vaccination offers an effective prospect for controlling the disease. Moreover alternative doses and/or routes of administration should be considered to evaluate the efficacy of the HIMB vaccine candidate.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

et al. 2017

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“…In high-prevalence areas, the eradication strategy of caprine TB based on test and slaughter may pose important economic costs for the producers and the public sector. Therefore, vaccination has been suggested as an option for reducing the prevalence prior to start eradication programs [5]. Nowadays, the M. bovis bacillus Calmette-Guerin (BCG), an attenuated strain of M. bovis, is the only available vaccine against TB.…”

Section: Introductionmentioning

confidence: 99%

Assessment of safety and interferon gamma responses of Mycobacterium bovis BCG vaccine in goat kids and milking goats

Val

Vidal

López-Soria

et al. 2016

Vaccine

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Vaccination of domestic animals has emerged as an alternative long-term strategy for the control of tuberculosis (TB). A trial under field conditions was conducted in a TB-free goat herd to assess the safety of the Mycobacterium bovis BCG vaccine. Eleven kids and 10 milking goats were vaccinated with BCG. Bacterial shedding and interferon gamma (IFN-γ) responses were monitored throughout the study. Comprehensive pathological examination and mycobacterial culture of target tissues were performed. BCG vaccine strain was only isolated from the draining lymph node of the injection site of a kid euthanized at week 8 post-vaccination. The remaining animals were euthanized at week 24. Six out of 20 showed small granulomas at the injection site. BCG shedding was not detected in either faeces or in milk throughout the study. All vaccinated kids showed BCG-induced IFN-γ responses at week 8 post-vaccination. BCG vaccination of goats showed no lack of biological safety for the animals, environment and public health, and local adverse reactions were negligible.

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The Control of Bovine Tuberculosis in Africa

Dibaba

Kriek

2019

Tuberculosis in Animals: An African Perspective

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Vaccination of domestic animals against tuberculosis: Review of progress and contributions to the field of the TBSTEP project

Cited by 27 publications

References 73 publications

Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

Assessment of BCG and inactivated Mycobacterium bovis vaccines in an experimental tuberculosis infection model in sheep

Assessment of safety and interferon gamma responses of Mycobacterium bovis BCG vaccine in goat kids and milking goats

The Control of Bovine Tuberculosis in Africa

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