Vaccination in Primary Immunodeficiency Disorders

Primary Immunodeficiency Disorders in India—A Situational Review

“…Children with PIDs may not mount an immune response to a given vaccine (e.g., response to pneumococcal vaccine in children with XLA), and these vaccines may not be indicated (12). On the other hand, a live vaccine may be deleterious as once a live bacterium or virus from a vaccine strain is administered to these patients, it is very difficult to eradicate this organism from the body of an immunocompromised child (12).…”

“…On the other hand, a live vaccine may be deleterious as once a live bacterium or virus from a vaccine strain is administered to these patients, it is very difficult to eradicate this organism from the body of an immunocompromised child (12). Oral live polio vaccine is still being used in India as a part of Polio Eradication and Endgame Strategic Plan and majority of children receive the first dose at birth.…”

Diagnosing inborn error of immunity following the presentation of a complicated acquired infection after MMRV vaccine administration

“…However, vaccination is a critical concern among immunocompromised patients, as these individuals have increased vulnerability to vaccine-acquired infections 2–4. An appropriately high index of suspicion for a potential association between a serious presentation of a disseminated viral or bacterial infection and vaccine administration is crucial in order to initiate prompt accelerated management and search for the underlying cause 3–6. Herein, we describe a case of successful management and new diagnosis of signal transducer and activator of transcription 1 (STAT1) genetic mutation in a 13-month-old child who presented with disseminated measles and varicella infection following the administration of Measles, Mumps, Rubella and Varicella (MMRV) vaccine.…”

Influenza immunization in patients with common variable immunodeficiency

“…Inactivated influenza virus vaccines are an exception to this rule and are indicated in patients whose cellular immunity is preserved, including all predominant antibody deficiency syndromes. [2][3][4] This indication for yearly influenza immunization is justified because human IgG preparations might not contain antibodies to the latest variants of the influenza virus. Furthermore, influenza vaccines can trigger cellular immunity, generating influenza-specific CD4 and CD8 T lymphocytes in patients unable to generate anti-influenza IgG antibodies.…”