Influenza immunization in patients with common variable immunodeficiency

Sorensen, Ricardo U.

doi:10.1016/j.jaci.2018.10.013

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Common Clinical Hallmarks Of the Humoral Immune Defects Group Of Crds During Transition1

Immune-modulating and Anti-inflammatory Medications1

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2020

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Cited by 2 publications

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“…Yearly influenza vaccination is recommended for patients with B-cell defects and household contacts. [12][13][14][15] Respiratory complications are the lifelong hallmark of this group of CRDs. 10,11 Chronic lung disease has a prevalence higher than 50% in almost all adult age groups with CVID, and it may affect almost half of patients with XLA by their 40s to 50s despite adequate levels of IRT.…”

Section: Common Clinical Hallmarks Of the Humoral Immune Defects Group Of Crds During Transitionmentioning

confidence: 99%

Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

Cirillo

Giardino

Ricci

et al. 2020

Journal of Allergy and Clinical Immunology

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Section: Common Clinical Hallmarks Of the Humoral Immune Defects Group Of Crds During Transitionmentioning

confidence: 99%

Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

Cirillo

Giardino

Ricci

et al. 2020

Journal of Allergy and Clinical Immunology

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“…Therefore, the above-mentioned vaccines are not indicated while on an IgRT plan, apart from influenza vaccination. Because influenza virus antigens change frequently and there is a significant delay between the time of donor IgG collection to the production of commercially available IgRT, IgRT might not contain the most seasonally relevant anti-influenza antibodies (98).…”

Section: Immune-modulating and Anti-inflammatory Medicationsmentioning

confidence: 99%

Bronchiectasis in Primary Antibody Deficiencies: A Multidisciplinary Approach

2020

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Bronchiectasis, the presence of bronchial wall thickening with airway dilatation, is a particularly challenging complication of primary antibody deficiencies. While susceptibility to infections may be the primary factor leading to the development of bronchiectasis in these patients, the condition may develop in the absence of known infections. Once bronchiectasis is present, the lungs are subject to a progressive cycle involving both infectious and non-infectious factors. If bronchiectasis is not identified or not managed appropriately, the cycle proceeds unchecked and yields advanced and permanent lung damage. Severe symptoms may limit exercise tolerance, require frequent hospitalizations, profoundly impair quality of life (QOL), and lead to early death. This review article focuses on the appropriate identification and management of bronchiectasis in patients with primary antibody deficiencies. The underlying immune deficiency and the bronchiectasis need to be treated from combined immunology and pulmonary perspectives, reflected in this review by experts from both fields. An aggressive multidisciplinary approach may reduce exacerbations and slow the progression of permanent lung damage.

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Influenza immunization in patients with common variable immunodeficiency

Cited by 2 publications

References 9 publications

Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

Consensus of the Italian Primary Immunodeficiency Network on transition management from pediatric to adult care in patients affected with childhood-onset inborn errors of immunity

Bronchiectasis in Primary Antibody Deficiencies: A Multidisciplinary Approach

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