Vaccinating captive chimpanzees to save wild chimpanzees

Warfield, Kelly L.; Goetzmann, Jason; Biggins, Julia E.; Kasda, Mary Beth; Unfer, Robert C.; Vu, Hong; Aman, M. Javad; Olinger, Gene G.; Walsh, Peter

doi:10.1073/pnas.1316902111

Cited by 34 publications

(33 citation statements)

References 28 publications

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“…So in 2011, he embarked on a novel experiment 3 . His team injected six chimpanzees with an experimental Ebola vaccine that had been developed for humans -thought to be the first time captive chimps had been vaccinated with the goal of preventing the spread of disease among apes.…”

Section: Vaccine Huntingmentioning

confidence: 99%

Ebola: The great ape gamble

Willyard

2017

Nature

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Section: Vaccine Huntingmentioning

confidence: 99%

Ebola: The great ape gamble

Willyard

2017

Nature

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“…[28][29][30][31][32][33][34][35][36][37][38] There is also a need to increase health workers' understanding on Ebola disease to improve healthcare like any other viral disease. [39] …”

Section: Drug and Vaccine Developmentmentioning

confidence: 99%

Past, Present and Future about Ebola Virus Diseases: An Updated Review

Mali¹,

Swapnil²,

Jadhav³

et al. 2016

JPPCM

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Ebola virus is responsible for the Ebola virus diseases. The epidemic of Ebola hemorrhagic fever is a deadly disease of animal can also be transmitted to human and non-human primates. The virulence of Ebola virus involved in several immune evasion mechanisms that include an inhibition of type I interferon responsible for innate immunity, epitope masking, etc. recently Ebola virus is sexually transmitted which was reported in Liberia has associated with new clusters in regions previously declared Ebola-free. There is no appropriate antiviral vaccine or therapy is not available to work against EBOV infection in humans. However, supportive recovery practices are performed include high-fluid intake, ventilator support and broad-spectrum antibiotic therapy. The treatment and diagnosis is very important because these kind of dangerous viruses are possibly used for bio-weapons. The present review describes briefly about virology, epidemiology, pathophysiology, transmission, diagnosis and treatment of Ebola viral disease.

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“…Just one example is that Ebola is having a devastating impact on already threatened populations of wild apes in central Africa 37 . Vaccines developed through research and testing in macaques and chimpanzees represent an opportunity to save some of these threatened populations 38 .…”

Section: Biomedical Advances From Primate Studiesmentioning

confidence: 99%

A brief history of primate research: Global health improvements and ethical challenges

Honess

2016

Arch Med Biomed Res

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Humans have benefitted from close relationships with animals for hundreds of thousands of years. However it has only been in relatively recent times that they have made use of the scientific investigation of animals; their anatomy, physiology and response to disease in attempts to alleviate human suffering. Scientists rapidly realized the value of primates as research models -their evolutionary proximity to humans making them better predictors, or models, of human biology. Systematic studies using primates began in the last century and massive demand for research subjects almost caused the extinction of some important wild populations. This resulted in initially ex situ and then latterly in situ breeding centers, purpose-breeding animals for biomedical research. Primate research typically follows that using less sentient animals (generally rodents) in which mechanism and proof of principle are established before examining effect and safety in primates. The quality of life of millions of people has rested on progress from primate research. The broader society has become more concerned with how we treat animals and use of animals in research has come under particular scrutiny. The actions of extremists have threatened not only the continued use of primates in research, but also the property, welfare, and occasionally, lives of those that have committed their careers to studying primates to aid humanity. This commentary examines the history of primate research and discusses key advances as well as important lessons learnt about the ethics surrounding the use of primates in research.

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Vaccinating captive chimpanzees to save wild chimpanzees

Cited by 34 publications

References 28 publications

Ebola: The great ape gamble

Ebola: The great ape gamble

Past, Present and Future about Ebola Virus Diseases: An Updated Review

A brief history of primate research: Global health improvements and ethical challenges

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