Vaccinating behaviour, information, and the dynamics of SIR vaccine preventable diseases

d’Onofrio, Alberto; Manfredi, Piero; Salinelli, Ernesto

doi:10.1016/j.tpb.2007.01.001

Cited by 203 publications

(261 citation statements)

References 21 publications

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“…More precisely, as far as p(C) is not too reactive to changing perceived risks of VSE the equilibrium is stable independently of the age mechanism through which VSE arise after vaccination. This agrees with our findings on different models of vaccinating behaviour [11,12,13]. However, as argued in previous work on prevalence-related vaccine uptake [23,11,13], we expect that in realistic circumstances the index M will embed not only the current but also some information on the past history of VSE.…”

Section: Modelling the Impact Of Information On Vaccine Side Effects supporting

confidence: 93%

“…Following ideas developed in d'Onofrio et al [11,13] we consider the following family of SIR models for a non-fatal disease in a constant homogeneously mixing population, with state-dependent vaccination coverage:…”

Section: Modelling the Impact Of Information On Vaccine Side Effects mentioning

confidence: 99%

“…causing disability, hospitalization, life-threatening illness or death [7]. In such circumstances it is natural to expect that the perceived risk of experiencing a VSE will outweight the perceived risk from infection [3,4,11]. A commonly brought example is Poliomyelitis 1 ([33] and references therein).…”

Section: Introductionmentioning

confidence: 99%

“…Vaccination free riding can take profit of the high degree of herd immunity existing in communities with high vaccine uptake [2,3,4,11]. In our previous work [11,12] we have described vaccination free-riding as "rational exemption", in order to distinguish it from other forms of exemption observed in the history of vaccination, e.g. conscientious, religious, or philosophical [24].…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of papers is being devoted to the study of the implications of rational exemption for the dynamics and control of vaccine preventable diseases. Some of these works model vaccine uptake using explicit economic arguments [4,23,21] while other use more mathematically manageable phenomenological representations [11,12]. As a rule all models based on homogeneous mixing, indicate that rational exemption might make eradication impossible.…”

Section: Introductionmentioning

confidence: 99%

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Vaccine demand driven by vaccine side effects: Dynamic implications for SIR diseases

d’Onofrio

Manfredi²

2010

Journal of Theoretical Biology

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Section: Modelling the Impact Of Information On Vaccine Side Effects supporting

confidence: 93%

Section: Modelling the Impact Of Information On Vaccine Side Effects mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vaccine demand driven by vaccine side effects: Dynamic implications for SIR diseases

d’Onofrio

Manfredi²

2010

Journal of Theoretical Biology

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Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles

Katagiri

Lee

Tetrault

et al. 2019

Adv Healthcare Materials

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Efficient and timely delivery of vaccine antigens to the secondary lymphoid tissue is crucial to induce protective immune responses by vaccination. However, determining the longitudinal biodistribution of injected vaccines in the body has been a challenge. Here, the near‐infrared (NIR) fluorescence imaging is reported that can efficiently enable the trafficking and biodistribution of vaccines in real time. Zwitterionic NIR fluorophores are conjugated on the surface of model vaccines and tracked the fate of bioconjugated vaccines after intradermal administration. Using an NIR fluorescence imaging system, it is possible to obtain time‐course imaging of vaccine trafficking through the lymphatics, observing notable uptake in lymph nodes with minimal nonspecific tissue interactions. Flow cytometry analysis confirmed that the uptake in lymph nodes by antigen presenting cells was highly dependent on the hydrodynamic diameter of vaccines. These results demonstrate that the combination of a real‐time NIR fluorescence imaging system and zwitterionic fluorophores is a powerful tool to determine the fate of vaccine antigens. Since such non‐specific vaccine uptake causes serious adverse reactions, this method is not only useful for optimization of vaccine design, but also for safety evaluation of clinical vaccine candidates.

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Global dynamics of a SEIR model with information dependent vaccination and periodically varying transmission rate

Bai

2014

Math. Meth. Appl. Sci.

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This paper is devoted to the investigation of the global dynamics of a SEIR model with information dependent vaccination. The basic reproduction number scriptR0 is derived for the model, and it is shown that scriptR0 gives the threshold dynamics in the sense that the disease‐free equilibrium is globally asymptotically stable and the disease dies out if scriptR0<1, while there exists at least one positive periodic solution and the disease is uniformly persistent when scriptR0>1. Further, we give the approximation formula of scriptR0. This answers the concerns presented in [B. Buonomo, A. d'Onofrio, D. Lacitignola, Modeling of pseudo‐rational exemption to vaccination for SEIR diseases, J. Math. Anal. Appl. 404 (2013) 385–398]. Copyright © 2014 John Wiley & Sons, Ltd.

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Vaccinating behaviour, information, and the dynamics of SIR vaccine preventable diseases

Cited by 203 publications

References 21 publications

Vaccine demand driven by vaccine side effects: Dynamic implications for SIR diseases

Vaccine demand driven by vaccine side effects: Dynamic implications for SIR diseases

Real‐Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles

Global dynamics of a SEIR model with information dependent vaccination and periodically varying transmission rate

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