Vacancy‐Modulated of CuS for Highly Antibacterial Efficiency via Photothermal/Photodynamic Synergetic Therapy

Abstract

Cu-based nanomaterials have been developed to alleviate the problem of antibiotic resistance due to their superior properties and good biocompatibility. Defects in nanomaterials have a major role in improving photocatalytic performance. Herein, two CuS nanospheres with predominant V CuSCu and V CuSS vacancy (abbreviated as CuS and CuS-T150, respectively) characterized by positron annihilation spectra are synthesized. The combination of experimental and theoretical calculation results demonstrates that CuS-T150 exhibits excellent antibacterial, achieving bactericidal rates of 99.9% against to Escherichia coli (E. coli) under 808 nm laser irradiation. Compared with CuS, the superior antimicrobial activity of CuS-T150 is mainly attributed to its stronger ability to adsorb oxygen molecules, more easily bind with surface of E. coli, and higher photothermal conversion efficiency (PTCE). This work provides a deeper understanding of nanomaterials with vacancy modulated the antibacterial efficiency by synergistic effect of photodynamic and photothermal therapy.

Protease-Loaded CuS Nanoparticles with Synergistic Photothermal/Dynamic Therapy against F. nucleatum-Induced Periodontitis

“…33 To date, increasing efforts have been put into dual-modality therapies of PDT and PTT. 34,35 Copper sulfide (CuS), a metal sulfide semiconductor, exhibits excellent photodynamic and photothermal properties under NIR light irradiation, attracting wide attention recently. 34,35 CuS-based NPs exhibit excellent antibacterial properties and can promote wound healing.…”

“…Moreover, the incorporation of PDT and PTT together can increase the feasibility of destroying bacteria than PDT and PTT alone since the penetration of ROS into the bacteria can be easier when the proteins and phospholipids on the cell membrane are damaged by the high temperature generated by PTT . To date, increasing efforts have been put into dual-modality therapies of PDT and PTT. , Copper sulfide (CuS), a metal sulfide semiconductor, exhibits excellent photodynamic and photothermal properties under NIR light irradiation, attracting wide attention recently. , CuS-based NPs exhibit excellent antibacterial properties and can promote wound healing. − …”

“…34,35 Copper sulfide (CuS), a metal sulfide semiconductor, exhibits excellent photodynamic and photothermal properties under NIR light irradiation, attracting wide attention recently. 34,35 CuS-based NPs exhibit excellent antibacterial properties and can promote wound healing. 36−38 Combining the features of PDT, PTT, and protease, we proposed that the modification of Alcalase 2.4L FG into CuS NPs (CuS@A NPs) via amide bonds could provide superior physicochemical properties to disrupt periodontitis-related biofilms and thus inhibit the progression of periodontitis (Figure 1).…”

Chiral Sulfur Nanosheets for Dual-Selective Inhibition of Gram-Positive Bacteria

“…To date, several kinds of sulfur nanomaterials, including sulfur nanoparticles, , sulfur nanorods, and sulfur quantum dots, have been synthesized as potential antibacterial agents and exhibit bactericidal ability due to their huge specific surface area. However, most sulfur nanomaterials still suffer from some shortcomings, such as nontarget killing, complex synthesis procedures, and limited improvement in bactericidal activity. ,, Another approach is the transformation into sulfur-based compounds (MoS 2 , , CuS, FeS 2 , etc.) via various synthesis strategies like hydrothermal reactions.…”

“…However, most sulfur nanomaterials still suffer from some shortcomings, such as nontarget killing, complex synthesis procedures, and limited improvement in bactericidal activity. 12,16,17 Another approach is the transformation into sulfurbased compounds (MoS 2 , 18,19 CuS, 20 FeS 2 , 21 etc.) via various synthesis strategies like hydrothermal reactions.…”