Vacancy-enhanced generation of singlet oxygen for photodynamic therapy

Abstract

Oxygen vacancy introduced defects in the band gap of BiOBr–H allow facile electron transfer from a photo-excited ruthenium complex to the semiconductor, thereby increasing ROS yields and PDT efficiency.

Antioxidant Activity Evaluation and Assessment of the Binding Affinity to HSA of a New Catechol Hydrazinyl-Thiazole Derivative

“…The presence of 1 O 2 in samples was quantified by the degradation of DPBF at room temperature by measuring UV-vis absorption spectra (Figure 3) at the beginning, before irradiation, and after every 10 s of irradiation for a total of 80 s. No significant modifications were observed in the absorbance spectra of DPBF during or after irradiation of the control sample (Figure 3D, gray). As expected, the biggest decrease in absorbance at 419 nm, corresponding with the decomposition of DPBF, was found in samples containing only ICG (Figure 3C), due to singlet oxygen generation (singlet oxygen quantum yield = 0.15 [20]). When ICG was associated with CHT or ascorbic acid as reference compound, a lower decrease in the absorbance was found at 419 nm, explained by the fact that DPBF is protected against the action of singlet oxygen radicals by the associated compounds (CHT or ascorbic acid).…”

“…In addition, we studied a mixture of ascorbic acid (10 −6 M) and ICG (10 −5 M) as standard for the antioxidant properties of CHT. Using the same experimental conditions, free DPBF in ethanol was used as a control [20]. The absorbance maxima of DPBF at 419 nm was recorded and the Φ( 1 O 2 ) was calculated using the following Equation (1):…”

“…is the oxygen singlet quantum yield of the investigated sample, -Φ( 1 O 2 ) ICG is the 1 O 2 quantum yield of ICG [20], -S is the slope of the absorbance difference of DPBF as a function of time, -F is the absorption correction factor determined as: F = 1 − 10 −OD , where OD is the optical density at 785 nm, the excitation wavelength.…”

Oxygen Vacancies Engineering–Mediated BiOBr Atomic Layers for Boosting Visible Light‐Driven Photocatalytic CO2 Reduction

“…73‐2061). [ 36 ] Moreover, the crystal structure of OV‐BiOBr‐1, OV‐BiOBr‐2, and OV‐BiOBr‐3 has not changed compared with BiOBr after UV light irradiation (Figure 1b). EPR spectroscopy is an effective technology to investigate the existence of OVs in those prepared semiconductors, there is a typical signal at g = 2.002, corresponding to the electrons trapped on OVs (Figure 1c).…”

Sonoactivated Chemodynamic Therapy: A Robust ROS Generation Nanotheranostic Eradicates Multidrug‐Resistant Bacterial Infection

“…By taking advantage of indirect bandgap transition and high chemical stability, BiOBr NPs have been advanced as nanomedicine for disease treatment with great effectiveness. [ 15 ] Nevertheless, most of these BiOBr NPs were employed in a photoirradiated way, which significantly limits their further application in deep‐seated disease treatment. To the best of our knowledges, we firstly found that the BiOBr NPs possess inherent sonocatalytic activity and can be effectively activated by low‐frequency ultrasound to generate ROS (Figure S1, Supporting Information), which is desirable for combating bacterial infection, especially for those that are deeply seated.…”