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Mockaitis, Keithanne; Estelle, Mark

doi:10.1186/gb-2004-5-11-245

Cited by 22 publications

(2 citation statements)

References 21 publications

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“…Statins have been shown to be able to accommodate into each of the four active sites of HMGCR interacting with seven key amino acid residues (Glu559, Arg590, Ser684, Asp690, Lys692, Lys735, Asn755) by ionic and dipole interactions [ 23 ]. In a first step of our simulation procedure, re-docking experiments have been performed in order to calculate the binding energy value for all the crystallographic statins into each binding site of the associated tetramer ( Table 2 , column 3).…”

Section: Resultsmentioning

confidence: 99%

Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

et al. 2021

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Tacle® is a citrus fruit obtained from the crossbreeding of Clementine and Tarocco cultivars. This fruit retains a promising nutraceutical potential most likely due to a high content in polyphenols, among which the main constituents are the two glycosides naringin and hesperidin. Herein, we evaluated, through an in vitro assay, the capability of Tacle extracts to inhibit the hydroxymethylglutaryl-CoA reductase enzyme, which plays a key role in cholesterol biosynthesis. The results obtained spurred us to investigate whether the anti-enzymatic activity observed may be due to a direct interaction of aglycones naringenin and hesperetin with the enzyme catalytic site. Molecular docking simulations indicated that these two compounds are able to anchor to the protein with binding modes and affinities similar to those found for statins, which represent mainstream medications against hypercholesterolemia. The overall results showed an interesting nutraceutical potential of Tacle, suggesting that its extract could be used for dietary supplementation in the treatment of moderate hypercholesterolemia.

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Section: Resultsmentioning

confidence: 99%

Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

et al. 2021

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“…Conversely, one ARF6a coding gene showed consistently lower expression levels for all the genotypes, when compared to VLB. ARFs are among the transcription factors responsible for controlling auxin response genes ( Guilfoyle and Hagen, 2001 ), which in turn control cell expansion ( Mockaitis and Estelle, 2004 ). In addition, ARF6a is reported to regulate photosynthesis, sugar accumulation and fruit development in Solanum lycopersicum ( Yuan et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Temporal Gene Expression in Apical Culms Shows Early Changes in Cell Wall Biosynthesis Genes in Sugarcane

et al. 2021

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Multiple genes in sugarcane control sucrose accumulation and the biosynthesis of cell wall components; however, it is unclear how these genes are expressed in its apical culms. To better understand this process, we sequenced mRNA from +1 stem internodes collected from four genotypes with different concentrations of soluble solids. Culms were collected at four different time points, ranging from six to 12-month-old plants. Here we show differentially expressed genes related to sucrose metabolism and cell wall biosynthesis, including genes encoding invertases, sucrose synthase and cellulose synthase. Our results showed increased expression of invertases in IN84-58, the genotype with lower sugar and higher fiber content, as well as delayed expression of secondary cell wall-related cellulose synthase for the other genotypes. Interestingly, genes involved with hormone metabolism were differentially expressed across time points in the three genotypes with higher soluble solids content. A similar result was observed for genes controlling maturation and transition to reproductive stages, possibly a result of selection against flowering in sugarcane breeding programs. These results indicate that carbon partitioning in apical culms of contrasting genotypes is mainly associated with differential cell wall biosynthesis, and may include early modifications for subsequent sucrose accumulation. Co-expression network analysis identified transcription factors related to growth and development, showing a probable time shift for carbon partitioning occurred in 10-month-old plants.

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Auxin Fuels the Cell Cycle Engine During Lateral Root Initiation

Vanneste¹,

Inzé²,

Beeckman³

Cell Cycle Control and Plant Development

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Abstract: In addition to independent transcriptional responses generated by auxin and brassinosteroid, recent microarray analyses indicate that these two plant hormones also coordinate the expression of a set of shared target genes.

Cited by 22 publications

References 21 publications

Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

Polyphenols from Citrus Tacle® Extract Endowed with HMGCR Inhibitory Activity: An Antihypercholesterolemia Natural Remedy

Temporal Gene Expression in Apical Culms Shows Early Changes in Cell Wall Biosynthesis Genes in Sugarcane

Auxin Fuels the Cell Cycle Engine During Lateral Root Initiation

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