V.V. Semchenko, S.S. Stepanov, N.N. Bogolepov «Brain synaptic plasticity (fundamental and applied aspects)

Semchenko, V. V.; Stepanov, S. S.; Боголепов, Н. Н.

doi:10.17116/jnevro201511561115

Cited by 8 publications

(6 citation statements)

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“…Study of the material: For morphological studies, the obtained material was subjected to standard histological treatment. The fixed testes were cut uniformly in the centre of the organ and the structural components of the gonads were studied in a standard organ slice area [10].…”

Section: Methodsmentioning

confidence: 99%

“…Examination, visualisation and morphometry of histological preparations of testes of offspring were performed using an Axioobserver inverted biological microscope for laboratory research with a D1 tripod by Carl Zeiss Microscopy GmbH (Germany), with specialised software ZEN 2018 (the microscope was provided by the Cell Culture Laboratory of the Central Scientific Research Laboratory of Bashkir State Medical University. To count the structural tissue elements in the progeny gonads, a 90x immersion lens was used, at standard fields of view [10].…”

Section: Methodsmentioning

confidence: 99%

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Morphology of the testes of animals during estrogen injection in the prenatal period

Sulaimanova,

Kvochko,

Askhabova

2023

E3S Web of Conf.

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The aim of the study was to investigate the morphological changes in the testes of the offspring of white non-pedigreed laboratory mice when the synthetic oestrogen analogue synestrol was prenatally injected to the mother. After fertilization, the females were divided into 2 groups which received a single intramuscular injection of the synthetic oestrogen analogue synestrol on day E 11.5 of gestation at the same time of the day. The intact group was not exposed to any treatment. The experimental group was exposed to synestrol, a synthetic oestrogen analogue, as a 2% oil solution at a dose of 40 µg/kg (C-40). The results of morphometric analysis of testes of descendants of white outbred laboratory mice after prenatal single injection of synthetic oestrogen analogue synestrol in a dose of 40 µg/kg showed morphological changes in the organ parenchyma, manifested as decrease in mean number of Sertoli cells (C-40) 17.4±1.1 compared to intact group 20.8±1.9; decrease in mean number of spermatogonia (C-40) 24.4±1.1 compared to intact group, decrease in mean number of spermatozoa (C-40) 178.0±4.2 compared to intact group 196.6±5.3. There was observed a change in the endocrine apparatus of testes, expressed as a decrease in the mean area of Leydig cell nuclei in the intact group of 6,72±1,78. Prenatal effects of synestrol revealed in an experimental model, allow us to use it to search for means of postnatal developmental testicular dysfunction correction as well as to develop optimal doses of oestrogenic preparations during pregnancy.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Morphology of the testes of animals during estrogen injection in the prenatal period

Sulaimanova,

Kvochko,

Askhabova

2023

E3S Web of Conf.

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“…Cerebral ischemia leads to a number of general and local metabolic and functional disorders, the pathogenesis of which is complex, many-sided and largely unclear [2,[4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Morphological Changes in Neurons of The Parietal Cortex and Hippocampus of Rats with Partial Cerebral Ischemia

Bon¹

2023

AIRT

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The study of the brain in health and disease is a relevant and promising area of modern science and, in this regard, a frequent topic of dissertation research. Cerebral ischemia leads to a number of general and local metabolic and functional disorders, the pathogenesis of which is complex, many-sided and largely unclear. The absence of pronounced morphological changes in the simulation of PCI after 1 hour in rats is explained by the compensation of blood circulation in the circle of Willis.

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“…Cerebral ischemia leads to a number of general and local metabolic and functional disorders, the pathogenesis of which is complex, multifaceted and largely unclear [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Improving cerebral circulation is one of the important effects of adaptation to hypoxia. It is based on an increase in vascular density[10][11][12][13][14].This neovascularization is explained by the production of NO and activation of hypoxia-induced transcription factor (HIF-1). This factor regulates the adaptive responses of the cell to changes in tissue oxygenation, improves oxygen delivery due to stimulation of erythropoiesis, angiogenesis, humoral and metabolic processes (activation of glucose transport, increased glycolytic production of ATP, ion transport) and cell proliferation.…”

mentioning

confidence: 99%

Changes In the Morphology of Neurons of The Parietal Cortex and Hippocampus of Rats in The Dynamics of Step Subtotal Cerebral Ischemia

Bon¹

2023

CSCR

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The study of the brain in norm and pathology is an urgent and promising direction of modern science and, in this regard, a frequent topic of dissertation research. Cerebral ischemia leads to a number of general and local metabolic and functional disorders, the pathogenesis of which is complex, multifaceted and largely. The aim was to change the morphology of neurons in the parietal cortex and hippocampus of rats in the dynamics of stepwise subtotal cerebral ischemia. With stepwise bilateral ligation of both common carotid arteries with an interval of 7 days, negative changes were least pronounced, especially in the hippocampus. The longer the interval between dressings, the more effectively neurons adapt to lack of oxygen, which makes it possible to further study in more detail the dynamics of the mechanisms of damage development and adaptive changes in the brain.

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V.V. Semchenko, S.S. Stepanov, N.N. Bogolepov «Brain synaptic plasticity (fundamental and applied aspects)

Cited by 8 publications

References 0 publications

Morphology of the testes of animals during estrogen injection in the prenatal period

Morphology of the testes of animals during estrogen injection in the prenatal period

Morphological Changes in Neurons of The Parietal Cortex and Hippocampus of Rats with Partial Cerebral Ischemia

Changes In the Morphology of Neurons of The Parietal Cortex and Hippocampus of Rats in The Dynamics of Step Subtotal Cerebral Ischemia

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