Changes In the Morphology of Neurons of The Parietal Cortex and Hippocampus of Rats in The Dynamics of Step Subtotal Cerebral Ischemia

Abstract

The study of the brain in norm and pathology is an urgent and promising direction of modern science and, in this regard, a frequent topic of dissertation research. Cerebral ischemia leads to a number of general and local metabolic and functional disorders, the pathogenesis of which is complex, multifaceted and largely. The aim was to change the morphology of neurons in the parietal cortex and hippocampus of rats in the dynamics of stepwise subtotal cerebral ischemia. With stepwise bilateral ligation of both common carotid arteries with an interval of 7 days, negative changes were least pronounced, especially in the hippocampus. The longer the interval between dressings, the more effectively neurons adapt to lack of oxygen, which makes it possible to further study in more detail the dynamics of the mechanisms of damage development and adaptive changes in the brain.

Changes in Amino Acid Pool in Rats with Brain Ischemia

“…The content of methionine also increased, in contrast to SCI and PCI, in which the content of methionine decreased, which may be due to the lack of activation of oxidative processes in this form of cerebral ischemia. Along with this, with TCI, as with SCI, PCI, and all types of SSCI, an increase in the content of L-arginine was noted, a tendency to an increase in the content of the inhibitory neurotransmitter glycine [35][36][37]. Also, when modeling TCI, the most pronounced morpho functional disorders were revealed: shriveled and disturbances in the ultrastructure of neurons, depression of mitochondrial respiration, and suppression of antioxidant protection .…”