Uveitis incidence in Jichi Medical University Hospital, Japan, during 2011-2015

Takahashi, Ryota; Yoshida, Atsushi; Inoda, Satoru; Ōkubo, Akira; Kawashima, Hidetoshi

doi:10.2147/opth.s132184

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…In China the highest percentage of panuveitis is reported [18], due to the high incidence of both VKH and Bechet disease (accounting respectively for 29-30% of all uveitis) [19]. In Japan VKH was considered the first cause of uveitis [18,20], but differences in etiology of uveitis are being observed over time [21], and in most recent studies it is reported as the second cause of uveitis (7% of all uveitis) after sarcoidosis [22,23]. On the other hand, higher VKH rates than expected are being recorded in South America: in Chile [24] VKH has been reported as the most frequent cause of uveitis, accounting for 17,2% of all uveitis, and in Argentina as the second cause after toxoplasmosis, accounting for 16.7% of all uveitis [18].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, neurological signs and dysacousia are quite common (74-76%) among Japanese patients [23,28], while intertegumentary signs are more often seen in Chinese patients (39-41%) [29]. When looking at ocular manifestations, studies conducted on South American patients are concordant in rating a optic disc swelling occurrence significantly lower than in Asian patients (8,6% -9% versus 50-73%, respectively) [26][27][28][29][30] Giordano et al) [26,30].…”

Section: Discussionmentioning

confidence: 99%

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Differentiating Vogt-Koyanagi-Harada syndrome from recurrent optic neuritis: a case report and review of the literature concerning Hispanic patients

Scarioni

Pietroboni

Invernizzi

et al. 2017

Mult Scler Demyelinating Disord

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Background: First recognized at the beginning of twentieth century and named after three authors who independently described some affected patients, Vogt-Koyanagi-Harada syndrome is a rare multisystemic autoimmune disease targeting melanin-containing tissues of the eye, meninges, inner ear and skin. It predominantly affects Asian people, but also people with darker skin pigmentation such as Native Americans and Hispanics (Mestizos), whose ancestors moved from Asia across the Bering strait to North America and further down to Central and South America. Heterogenous presentation is observed, especially among different ethnic groups. Here we describe the case of an Hispanic South American patient presenting with multiple visual relapses and thus mimicking recurrent optic neuritis; we provide insights into the differential diagnosis and a brief review of the literature concerning the epidemiology of Vogt-Koyanagi-Harada syndrome in Hispanic patients compared with other ethnic groups. Case presentation: A 34-year-old Ecuadorian woman presented over years with multiple relapses involving the visual system. She was investigated in both neurologic and ophthalmic clinical settings. Brain Magnetic Resonance Imaging, cerebrospinal fluid examination, Spectral Domain Optical Coherence Tomography and Fluorescein Angiography were performed. She was misdiagnosed first as an optic neuritis pointing to a demyelinating disorder, then as a posterior scleritis. Due to the protean manifestations of Vogt-Koyanagi-Harada syndrome and the incomplete clinical presentation at the beginning, the right diagnosis was made only at a later disease stage using retrospective criteria. Conclusions: Hispanic patients often present without extraocular symptoms in early phases of the disease and they have globally lower rates of intertegumentary signs compared to Asian patients. The diagnosis of a multisystemic disease such as Vogt-Koyanagi-Harada syndrome is a challenge involving specialists operating in different medical fields; especially in urban multiethnic populations, rare etiologies of common symptoms have to be taken into account when performing a differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Differentiating Vogt-Koyanagi-Harada syndrome from recurrent optic neuritis: a case report and review of the literature concerning Hispanic patients

Scarioni

Pietroboni

Invernizzi

et al. 2017

Mult Scler Demyelinating Disord

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“…For example, compared with patients before 2010, recent patients in Singapore showed a higher percentage of infectious uveitis [26]. Studies in Japan have revealed that 35-63% of uveitis cases were noninfectious, and 31-50% were idiopathic [7,[27][28][29][30][31][32]. These studies have also demonstrated that the patterns and specific entities of uveitis, including endophthalmitis, sarcoidosis, Bechet's disease, VKH disease, and anterior uveitis, have changed with time.…”

Section: Epidemiology and Distribution Of Etiologiesmentioning

confidence: 99%

Noninfectious uveitis in the Asia–Pacific region

Hsu

Huang

Tao

et al. 2018

Eye

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Uveitis is a sight-threatening disease. Up to 35% of patients may have impaired vision. Inflammation of the uvea tissue has more than 60 etiologies. Previous reports have shown that 20-40% of uveitis cases were noninfectious. Some of them may be associated with systemic rheumatological and autoimmune diseases but some may affect the eyes only. The epidemiology and clinical situations of some specific uveitis entities vary worldwide because they are influenced by genetic, ethnic, environmental, and socioeconomic factors. The Asia-Pacific region comprises more than 30 countries. Epidemiology and patterns of uveitis vary greatly in this region. However, some uveitis entities, such as Behcet's disease, sarcoidosis, and Vogt-Koyanagi-Harada disease, are more common in this region. Many studies on the epidemiology, risk factors, and immune pathogenesis of this disease have been conducted. In this article, we review the epidemiology of noninfectious uveitis and special situations of these three uveitis entities in the Asia-Pacific region.

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