Noninfectious uveitis in the Asia–Pacific region

Hsu, Yung-Ray; Huang, Jerry Chien-Chieh; Tao, Yong; Kaburaki, Toshikatsu; Lee, Christopher Seungkyu; Lin, Tzu‐Chin; Hsu, Chih Chien; Chiou, Shih Hwa; Hwang, De‐Kuang

doi:10.1038/s41433-018-0223-z

Cited by 57 publications

(34 citation statements)

References 91 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Noninfectious uveitis (NIU), also known as autoimmune uveitis, is an autoimmune disease inside the eye that aims at the neuroretina [ 49 ]. NIU can be associated with other autoimmune diseases, including RA, IBD, and PS.…”

Section: Tnf-α Signaling In Autoimmune Diseasesmentioning

confidence: 99%

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Jang

Lee

Shin

et al. 2021

IJMS

705

377

View full text Add to dashboard Cite

Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways. These pathways lead to various cellular responses, including cell survival, differentiation, and proliferation. However, the inappropriate or excessive activation of TNF-α signaling is associated with chronic inflammation and can eventually lead to the development of pathological complications such as autoimmune diseases. Understanding of the TNF-α signaling mechanism has been expanded and applied for the treatment of immune diseases, which has resulted in the development of effective therapeutic tools, including TNF-α inhibitors. Currently, clinically approved TNF-α inhibitors have shown noticeable potency in a variety of autoimmune diseases, and novel TNF-α signaling inhibitors are being clinically evaluated. In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases.

show abstract

Section: Tnf-α Signaling In Autoimmune Diseasesmentioning

confidence: 99%

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

Jang

Lee

Shin

et al. 2021

IJMS

705

377

View full text Add to dashboard Cite

show abstract

“…There are some limitations in the current study. First, a group with patients diagnosed with CRS but without the arrangement of FESS should be included to make the statistical analysis more complete, but this could not be conducted due to the overestimation rate of CRS, which may lead to some confusion [31][32][33][34]. In addition, the retrospective and observational nature of study design might reduce the homogeneity of the patient population even after multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Lee

Yang

Sun

et al. 2020

IJERPH

View full text Add to dashboard Cite

We aim to evaluate the risk of dry eye disease (DED) occurrence in patients with surgery-indicated chronic rhinosinusitis (CRS) via the national health insurance research database in Taiwan. After exclusion, patients with a diagnostic code of CRS and had received functional endoscopic sinus surgery (FESS) were regarded as having surgery-indicated CRS and enrolled in the study group, then each patient in the study group was age- and gender-matched to four non-CRS patients that served as the control group. The outcome was considered as the development of DED and Cox proportional hazard regression was used for the statistical analysis, which involved multiple potential risk factors of DED. A total of 6076 patients with surgery-indicated CRS that received FESS and another 24,304 non-CRS individuals were enrolled after exclusion. There were 317 and 770 DED events in the study group and the control group during the 16-year follow-up interval, and the study group demonstrated a significantly higher adjusted hazard ratio (1490, 95% confidence intervals (CI): 1.303-1.702) of DED development compared to the control group in the multivariable analysis. In addition, the cumulative probability analysis illustrated a positive correlation of DED occurrence and the disease period of surgery-indicated CRS (p < 0.0001). In the subgroup analysis, both genders revealed a higher but not significant incidence of developing DED in the study group. In conclusion, the existence of surgery-indicated CRS will increase the risk of developing DED, which correlated to the disease interval.

show abstract

“…The types of inflammation associated with uveitis can be divided into infectious and non-infectious causes. Moreover, noninfectious uveitis, including immune-mediated diseases, may be related to other systemic diseases, or partial makeup syndrome, such as ankylosing spondylitis, Behcet's disease, sarcoidosis, VKH disease, and juvenile idiopathic arthritis (12)(13)(14)(15). The cause of uveitis may be infectious, such as viruses, bacteria, parasites, and fungi.…”

Section: Introductionmentioning

confidence: 99%

Association Between Air Pollution and the Risk of Uveitis: A Nationwide, Population-Based Cohort Study

et al. 2021

View full text Add to dashboard Cite

Previous studies have revealed an association between ocular surface disorders and air pollution, few studies have focused on the risk of uveitis. We aimed to investigate whether air pollution increases the risk of uveitis. We used the Taiwan Longitudinal Health Insurance Database (LHID) and the Taiwan Air Quality Monitoring Database (TAQMD) to conduct a retrospective cohort study. Air pollutant concentrations, including those of carbon dioxide (CO2), were grouped into four levels according to quartiles. The outcome was the incidence of uveitis, as defined in the International Classification of Diseases, Ninth Revision. We used univariable and multivariable Cox proportional hazard regression models to calculate the adjusted hazard ratios (aHRs) and determine the potential risk factors of uveitis. Overall, 175,489 subjects were linked to their nearby air quality monitoring stations. We found that for carbon monoxide, the aHRs of uveitis risk for the Q3 and Q4 levels were 1.41 (95% confidence interval (CI) = 1.23–1.61) and 2.19 (95% CI = 1.93–2.47), respectively, in comparison with those for the Q1 level. For nitric oxide, the aHRs for the Q3 and Q4 levels were 1.46 (95% CI = 1.27–1.67) and 2.05 (95% CI = 1.81–2.32), respectively. For nitrogen oxide (NOx), the aHRs for the Q2, Q3, and Q4 levels were 1.27 (95% CI = 1.11–1.44), 1.34 (95% CI = 1.16–1.53), and 1.85 (95% CI = 1.63–2.09), respectively. For total hydrocarbon (THC), the aHRs for the Q2, Q3, and Q4 levels were 1.42 (95% CI = 1.15–1.75), 3.80 (95% CI = 3.16–4.57), and 5.02 (95% CI = 4.19–6.02), respectively. For methane (CH4), the aHRs for the Q3 and Q4 levels were 1.94 (95% CI = 1.60–2.34) and 7.14 (95% CI = 6.01–8.48), respectively. In conclusion, air pollution was significantly associated with incidental uveitis, especially at high THC and CH4 levels. Furthermore, the uveitis risk appeared to increase with increasing NOx and THC levels.

show abstract

Noninfectious uveitis in the Asia–Pacific region

Cited by 57 publications

References 91 publications

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics

The Development of Dry Eye Disease after Surgery-Indicated Chronic Rhinosinusitis: A Population-Based Cohort Study

Association Between Air Pollution and the Risk of Uveitis: A Nationwide, Population-Based Cohort Study

Contact Info

Product

Resources

About