Uveitis in a tertiary ophthalmology centre in Thailand

Pathanapitoon, Kessara; Kunavisarut, Paradee; Ausayakhun, Somsanguan; Sirirungsi, Wasna; Rothová, Aniki

doi:10.1136/bjo.2007.132175

Cited by 54 publications

(48 citation statements)

References 24 publications

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“…Although T. gondii and herpetic infections were recognized as the major causes of infectious posterior and panuveitis (PU) in Asian populations, in those studies, the specific diagnoses were based mainly on clinical grounds, sometimes in combination with laboratory blood analysis and imaging studies of the chest [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Infectious causes of posterior uveitis and panuveitis in Thailand

et al. 2012

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Section: Introductionmentioning

confidence: 99%

Infectious causes of posterior uveitis and panuveitis in Thailand

et al. 2012

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“…Infectious causes of AU are increasingly being recognized; specifically cytomegalovirus (CMV) and Rubella virus have been reported as infectious causes of AU in immunocompetent patients. [3][4][5][6] Herpetic AU is considered the most common cause of infectious AU in the Western countries. 1 Recent study from Asia revealed that HIV-negative patients with hypertensive AU regularly had intraocular CMV infection.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Its etiology includes various infectious and non-infectious causes, but remains regularly undetermined. Infectious causes of AU are increasingly being recognized; specifically cytomegalovirus (CMV) and Rubella virus have been reported as infectious causes of AU in immunocompetent patients.…”

Section: Introductionmentioning

confidence: 99%

Viral causes of unexplained anterior uveitis in Thailand

Kongyai

Sirirungsi

Pathanapitoon

et al. 2012

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Aims To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU). Methods Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by realtime polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Results Viral uveitis determined by either real-time PCR and/or GWC was documented in 20 out of 30 patients (67%). Of 30 paired samples tested by both methods for HSV, CMV, and VZV, 15 showed positive results (CMV (10), HSV (4), and VZV (1)). Real-time PCR was positive in 8/15 (53%), whereas GWC was positive in 10/15 (67%). Out of 10 CMV-positive patients, four had endotheliitis, two had Posner-Schlossman syndrome, and one Fuchs heterochromic uveitis syndrome (FHUS). Five out of 21 (24%) samples tested by GWC for Rubella virus were positive, three of which exhibited clinical features of FHUS. Conclusions Our results indicate that CMV is a major cause of AU in Thailand and show that FHUS can be caused by both CMV and Rubella virus.

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“…In our previous study, we identified presumed ocular TB in 3out of 138 (2%) of new uveitis patients who were human immunodeficiency virus-negative. 8 Recently, the association between latent TB and uveitis was described. 20 The interferon gamma release assay such as the Quantiferon test was not used in our series, and therefore, the number of patients with uveitis, which might have been related to latent TB, was not identified.…”

Section: Discussionmentioning

confidence: 99%

“…6,7 In Thailand, systemic sarcoidosis has rarely been diagnosed and so far, no cases with ocular sarcoidosis have been reported. 8,9 In this study, we explore the possibility of pulmonary sarcoidosis in 209 new consecutive patients with uveitis and describe ocular features of four Thai patients with signs of associated pulmonary sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

Ocular sarcoidosis in Thailand

Pathanapitoon

Goossens

Tilborg

et al. 2010

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Purpose To determine the prevalence of pulmonary sarcoidosis in patients with uveitis from the University Referral Centre in Thailand and to report on their clinical characteristics. Methods We performed a retrospective review of results of radiological examinations of 209 consecutive new patients, diagnosed with uveitis. In patients with signs of pulmonary sarcoidosis, we reviewed clinical characteristics including age, gender, laterality and anatomical location of uveitis, and complications.Results From 209 chest X-ray (CXR) examinations, one patient exhibited radiological signs typical of stage 1 sarcoidosis. Chest CT of three patients with posterior multifocal chorioretinitis (PMC) revealed abnormalities suggesting the diagnosis of pulmonary sarcoidosis. All PMC patients were females older than 50 years; they had no pulmonary complaints and their CXRs were without abnormalities. Conclusion Ocular sarcoidosis is prevalent in Thailand and our findings suggest that possibly more patients with sarcoidosis would be identified if diagnosis was thought of and ancillary tests were performed.

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Uveitis in a tertiary ophthalmology centre in Thailand

Cited by 54 publications

References 24 publications

Infectious causes of posterior uveitis and panuveitis in Thailand

Infectious causes of posterior uveitis and panuveitis in Thailand

Viral causes of unexplained anterior uveitis in Thailand

Ocular sarcoidosis in Thailand

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