Infectious causes of posterior uveitis and panuveitis in Thailand

Kongyai, Natedao; Pathanapitoon, Kessara; Sirirungsi, Wasna; Kunavisarut, Paradee; Groot-Mijnes, Jolanda D.F. de; Rothová, Aniki

doi:10.1007/s10384-012-0144-5

Cited by 16 publications

(11 citation statements)

References 33 publications

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“…In the current study, the majority of patients positive for VZV-DNA had acute anterior uveitis, which was consistent with data from previous literature [Jap and Chee, 2011]. VZV was also described as an etiologic agent of acute retinal necrosis and other different types of uveitis [Miserocchi et al, 2002;Tran et al, 2003;Bonfioli and Eller, 2005;Kido et al, 2008;Rothova et al, 2008;Lee et al, 2011;Kongyai et al, 2012]. In fact, VZV was found in four acute retinal necrosis, intermediate uveitis, posterior uveitis, keratouvetis, and bilateral panuveitis cases.…”

Section: Hhv Detectionsupporting

confidence: 92%

Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

Nahdi

Abdelwahed

Boukoum

et al. 2013

Journal of Medical Virology

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Human herpesviruses (HHVs) are involved in the pathogenesis of different types of uveitis. Cytokine response plays an important role in virus-induced immunopathology. This study aimed to investigate the incidence of HHVs in aqueous humor samples of immunocompetent patients with suspected viral uveitis and cytokine (IL-10, IL-6, and IFN-γ) expression profiling. Forty-seven aqueous humor samples were collected from immunocompetent patients with viral uveitis. Samples were assayed for HHV-1 to HHV-8 by in-house real-time polymerase chain reactions. IL-6, IL-10, and IFN-γ were quantified with a cytometric bead array. Relations between viral detection, cytokine profiles, and clinical data were studied. At least one viral genome was detected in 21 aqueous humor samples analyzed. Varicella-zoster virus (VZV) was detected in 14 of the positive samples, cytomegalovirus (CMV) in 8, HSV-1 in 1, Epstein-Barr virus (EBV) in 4, and HHV-6 in 2. More than one viral genome was detected in seven aqueous humor samples. Aqueous humor samples positive for HHV-DNA contained significant levels of IL-6, IL-10, and IFN-γ, compared to HHV-DNA negative samples. High levels of IL-6 were detected in patients with CMV-DNA in their aqueous humor samples. Significantly higher levels of IL-10 and IFN-γ were found in positive samples for VZV, EBV, and HHV-6 DNA than in negative aqueous humor ones. VZV was the principal etiologic agent of uveitis in this Tunisian series, with CMV the second most common agent. Knowledge of immunoregulatory interactions and dynamic changes in viral uveitis may be a key to understand the pathogenesis leading to more-effective treatments.

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Section: Hhv Detectionsupporting

confidence: 92%

Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

Nahdi

Abdelwahed

Boukoum

et al. 2013

Journal of Medical Virology

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“…Cytomegalovirus (CMV) is also known to cause AU in immunocompetent individuals [4][5][6][7][8][9][10][11][12]. The diagnosis of AU caused by these viruses (HSV-AU, VZV-AU, CMV-AU, respectively) has benefited from the use of PCR technology to detect the genomic DNA of the respective herpes virus in small amounts of ocular fluids [11,13,14].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus

et al. 2014

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“…Generally, blood tests for detection of toxoplasma antibodies of acute phase (IgA, IgM) have only supporting significance and may be even negative in cases of isolated eye disease. The seroprevalence (IgG) for Toxoplasma gondii is high in western Europe (41-75%) whereas in Vietnam, China and Thailand it is low 1,[25][26][27] . Causes for these regional differences are unknown; various factors such as diet, hygiene, infection of the environment by cyst and differences in pathogenicity of the regional strains might be involved 1 .…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, posterior uveitis is more frequent in Africa, Asia and South America. Among infectious agents, the most common are herpes viruses and Toxoplasma gondii [1][2][3][4][5] . Many etiological agents are ubiquitous, e.g.…”

Section: Introductionmentioning

confidence: 99%

Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study

et al. 2020

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Aims. Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches. Methods. A retrospective study. Results. In years 2003-2017, we diagnosed 594 patients with infectious uveitis. In 35 of them, infectious uveitis occurred on the basis of immunodeficiency (malignancy, immunosuppressive therapy etc.). The most common infectious uveitis was cytomegalovirus retinitis, followed by acute retinal necrosis, herpetic anterior uveitis, endogenous fungal endophthalmitis, toxoplasmic retinochoroiditis, progressive outer retinal necrosis and syphilis. In indicated cases, intraocular fluid examination was a valuable diagnostic tool. After initiation of treatment, improvement of BCVA was observed in 13 eyes, stabilization in 13 eyes and deterioration in 11 eyes. In some patients who experienced adverse effects of medication, the recommended doses were decreased. Conclusion. Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis.

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Infectious causes of posterior uveitis and panuveitis in Thailand

Abstract: CMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1-negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis.

Cited by 16 publications

References 33 publications

Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

Herpesvirus detection and cytokine levels (IL‐10, IL‐6, and IFN‐γ) in ocular fluid from Tunisian immunocompetent patients with uveitis

Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus

Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study

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