Uveitis genetics

Hou, Shengping; Li, Na; Liao, Xian; Kijlstra, Aize; Yang, Peizeng

doi:10.1016/j.exer.2019.107853

Cited by 41 publications

(40 citation statements)

References 42 publications

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“…Epigenetic processes including DNA methylation, histone modification, non-coding RNA (ncRNA), and especially microRNA (miRNA) are thought to be associated with the pathogenesis of BD (Leccese and Alpsoy, 2019). Some genetic or epigenetic factors combined with imbalances in immune regulation lead to the development of BD (Hou et al, 2020). Changes in the methylation level of IRS elements in diffuse repeat sequences, histone modification, and miRNA regulationmediated gene silencing play a role in the control of immune and inflammatory responses and are related to the pathogenesis of autoimmune diseases, but the specific mechanisms are unknown (Alipour et al, 2017;Leccese and Alpsoy, 2019).…”

Section: Epigenetics and Behçet's Diseasementioning

confidence: 99%

“…NcRNA involved in epigenetic processes varies according to sequence length. It can be divided into short ncRNA (<30 nucleotides) and long ncRNA (lncRNA) (>200 nucleotides) (Hanson and Gluckman, 2008;Alipour et al, 2017;Hou et al, 2020). NcRNA may be used for disease diagnosis and/or treatment in the future (Akbaba et al, 2020).…”

Section: Non-coding Rna and Behçet's Diseasementioning

confidence: 99%

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Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Wang

Zheng

et al. 2021

Front. Cell Dev. Biol.

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Behçet’s disease (BD) is a chronic refractory multisystem autoinflammatory disease, characterized by typical clinical features of non-specific vasculitis, oral and genital ulcers, uveitis, as well as skin lesions. The exact etiopathogenesis of BD remains unknown, existing studies have indicated that genetics and environmental factors contribute to the increased development of BD. Recently, several studies have shown that external environmental factors can affect the process of epigenetic modification, and abnormalities of epigenetic factors have been confirmed to be involved in the occurrence of BD. At the same time, abnormalities of gut microbiota (GM) in the body, have also been confirmed to participate in the pathogenesis of BD by regulating the balance of Th17/Tregs. This article reviews the pathogenesis of BD and summarizes numerous clinical studies, focusing on the mechanism of GM and epigenetic factors impacting on BD, and providing new ideas for further elucidating the pathogenesis of BD.

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Section: Epigenetics and Behçet's Diseasementioning

confidence: 99%

Section: Non-coding Rna and Behçet's Diseasementioning

confidence: 99%

Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Wang

Zheng

et al. 2021

Front. Cell Dev. Biol.

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“…According to the most widely accepted criteria for BD published by the international research group (ISG) in 1990, uveitis is an important diagnostic criterion for ( Criteria for diagnosis of Behcet’s disease, 1990 ). Furthermore, BD and VKH disease are the most common non-infectious uveitis entities seen in Asia ( Pineton de Chambrun et al, 2012 ; Hou et al, 2020 ). Although there is increasing evidence about the pathogenesis of BD, its actual etiology is still unclear.…”

Section: Epigenetic Modifications In Different Types Of Uveitismentioning

confidence: 99%

“…The pathogenesis of uveitis has been considered to depend on complex interactions between multiple genetic substances and environmental risk factors. Genome-wide association studies (GWASs) have provided a powerful tool for the genome-wide analysis of genetic susceptibility to uveitis, revealing several genes associated with uveitis, including IL23R/C1ORF141, STAT4, and ADO/ZNF365/Egr2 ( Hou et al, 2020 ). However, there are still some mechanisms that cannot be solved by genetics, and it is necessary to further study epigenetic modifications to explore the lack of heritability in uveitis risk ( Hou et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Modifications and Therapy in Uveitis

Zou

Xue

et al. 2021

Front. Cell Dev. Biol.

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Uveitis is a sight-threatening intraocular inflammation, and the exact pathogenesis of uveitis is not yet clear. Recent studies, including multiple genome-wide association studies (GWASs), have identified genetic variations associated with the onset and progression of different types of uveitis, such as Vogt–Koyanagi–Harada (VKH) disease and Behcet’s disease (BD). However, epigenetic regulation has been shown to play key roles in the immunoregulation of uveitis, and epigenetic therapies are promising treatments for intraocular inflammation. In this review, we summarize recent advances in identifying epigenetic programs that cooperate with the physiology of intraocular immune responses and the pathology of intraocular inflammation. These attempts to understand the epigenetic mechanisms of uveitis may provide hope for the future development of epigenetic therapies for these devastating intraocular inflammatory conditions.

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“…Uveitis, which is an autoimmune ophthalmopathy, accounts for approximately 10–15% of legal blindness in Western countries ( Nussenblatt, 1990 ; Wakefield and Chang, 2005 ; Hou et al, 2015 ). Furthermore, compared with some common age-related eye diseases, uveitis may have a greater socioeconomic impact because it is more prevalent among younger working-age patients ( Suttorp-Schulten and Rothova, 1996 ; Hou et al, 2020 ). At present, the etiology of uveitis is still unknown, and the pathogenesis is complicated.…”

Section: Introductionmentioning

confidence: 99%

Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA

Zhou

Liao

et al. 2021

Front. Cell. Neurosci.

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The N6-methyladenosine (m6A) modification is the most abundant posttranscriptional mRNA modification in mammalian cells and is dynamically modulated by a series of “writers,” “erasers,” and “readers.” Studies have shown that m6A affects RNA metabolism in terms of RNA processing, nuclear export, translation, and decay. However, the role of the m6A modification in retinal microglial activation remains unclear. Here, we analyzed the single-cell RNA sequencing data of retinal cells from mice with uveitis and found that the m6A-binding protein YTH domain-containing 1 (YTHDC1) was significantly downregulated in retinal microglia in the context of uveitis. Further studies showed that YTHDC1 deficiency resulted in M1 microglial polarization, an increased inflammatory response and the promotion of microglial migration. Mechanistically, YTHDC1 maintained sirtuin 1 (SIRT1) mRNA stability, which reduced signal transducer and activator of transcription 3 (STAT3) phosphorylation, thus inhibiting microglial M1 polarization. Collectively, our data show that YTHDC1 is critical for microglial inflammatory response regulation and can serve as a target for the development of therapeutics for autogenic immune diseases.

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Uveitis genetics

Cited by 41 publications

References 42 publications

Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Epigenetic Modifications and Therapy in Uveitis

Low Expression of YTH Domain-Containing 1 Promotes Microglial M1 Polarization by Reducing the Stability of Sirtuin 1 mRNA

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