Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Ma, Xiaomin; Wang, Xin; Zheng, Guangbing; Tan, Guiqin; Zhou, Fangyu; Wei, Wuran; Tian, Dan; Yu, Hongsong

doi:10.3389/fcell.2021.719235

Cited by 9 publications

(9 citation statements)

References 86 publications

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“…These epigenetic factors could be a mediator in coordinating GM of the host 23 . Any alteration of GM affects the beneficial microflora and this interferes with normal epigenetic control mechanisms in addition to the suppression of the immune system 24 . For instance, the regulation of T‐helper 17 (Th17)/regulatory T cells (Tregs) by GM and the process of EM are both involved in the etio pathogenesis of Behçet's disease 25 .…”

Section: Discussionmentioning

confidence: 99%

“…23 Any alteration of GM affects the beneficial microflora and this interferes with normal epigenetic control mechanisms in addition to the suppression of the immune system. 24 For instance, the regulation of T-helper 17 (Th17)/regulatory T cells (Tregs) by GM and the process of EM are both involved in the etio pathogenesis of Behçet's disease. 25 Both fecal microbiota transplantation (FMT) for GM and epigenetic modulators have higher response rates and antitumor efficacies for antibodies targeting programmed cell death protein-1.…”

Section: Epigenetics and Gmmentioning

confidence: 99%

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The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

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Both the epigenetic changes and gut microbiota (GM) have attracted a growing interest in establishing effective diagnostics and potential therapeutic strategies for a number of diseases. These disorders include metabolic, central nervous system‐related diseases, autoimmune, and gastrointestinal infections (GI). Despite the number of studies, there is no extensive review that connects the epigenetics modifications and GM as biomarkers that could confer effective diagnostics and confer treatment options. To this end, this review hopes to give detailed information on connecting the modifications in epigenetic and GM. An updated and detailed information on the connection between the epigenetics factors and GM that influence diseases are given. In addition, the review showed some associations between the epigenetics to the maternal GM and offspring health. Finally, the limitations of the concept and prospects into this new emerging discipline were also looked into. Although this review elucidated on the maternal diet and response to offspring health with respect to GM and epigenetic modifications, there still exist various limitations to this newly emerging discipline. In addition to integrating complementary multi‐omics data, longitudinal sampling will aid with the identification of functional mechanisms that may serve as therapeutic targets. To this end, this review gave a detailed perspective into harnessing disease diagnostics, prevention and treatment options through epigenetics and GM.

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Section: Discussionmentioning

confidence: 99%

Section: Epigenetics and Gmmentioning

confidence: 99%

The connection between epigenetics and gut microbiota‐current perspective

Yuan,

Tan,

Bajinka

et al. 2024

Cell Biochemistry & Function

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“…Based on our results and the literature ( 40 ), the possible mechanisms are shown in Figure 10 . Studies ( 41 , 42 ) suggest that intestinal dysbacteriosis may promote the pathogenesis of BD through various mechanisms, such as damaging the intestinal mucosal barrier, inducing the overactivation of Th1 and Th17 responses, and reducing the number of Tregs. In addition to oral ulcers, BD patients have systemic manifestations different from those of RAU.…”

Section: Discussionmentioning

confidence: 99%

A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide

Wang

Xiong²,

Huang³

et al. 2022

Front. Immunol.

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Recurrent aphthous ulcer (RAU), one of the most common diseases in humans, has an unknown etiology and is difficult to treat. Thalidomide is an important immunomodulatory and antitumor drug and its effects on the gut microbiota still remain unclear. We conducted a metagenomic sequencing study of fecal samples from a cohort of individuals with RAU, performed biochemical assays of cytokines, immunoglobulins and antimicrobial peptides in serum and saliva, and investigated the regulation effects of thalidomide administration and withdrawal. Meanwhile we constructed the corresponding prediction models. Our metagenome-wide association results indicated that gut dysbacteriosis, microbial dysfunction and immune imbalance occurred in RAU patients. Thalidomide regulated gut dysbacteriosis in a species-specific manner and had different sustainable effects on various probiotics and pathogens. A previously unknown association between gut microbiota alterations and RAU was found, and the specific roles of thalidomide in modulating the gut microbiota and immunity were determined, suggesting that RAU may be affected by targeting gut dysbacteriosis and modifying immune imbalance. In-depth insights into sophisticated networks consisting of the gut microbiota and host cells may lead to the development of emerging treatments, including prebiotics, probiotics, synbiotics, and postbiotics.

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“…Histone modifications have been found to play a role in the activation of the NLRP3 inflammasome and subsequently in the manifestation of multiple autoimmune and autoinflammatory disorders, such as systemic lupus erythematosus [ 47 ], rheumatoid arthritis [ 48 ], Behçet disease (BD) [ 49 ], atherosclerosis, and Alzheimer’s disease [ 50 ]. Nevertheless, to date, no study has investigated the role of histone modifications in FMF, despite the relevant implication of the NLRP3 inflammasome in the pathogenesis of this disease.…”

Section: Histone Modificationmentioning

confidence: 99%

Updates on the role of epigenetics in familial mediterranean fever (FMF)

Chaaban,

Salman,

Karam

et al. 2024

Orphanet J Rare Dis

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Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease caused by mutations in the MEFV (MEditerranean FeVer) gene that affects people originating from the Mediterranean Sea. The high variability in severity and clinical manifestations observed not only between ethnic groups but also between and within families is mainly related to MEFV allelic heterogeneity and to some modifying genes. In addition to the genetic factors underlying FMF, the environment plays a significant role in the development and manifestation of this disease through various epigenetic mechanisms, including DNA methylation, histone modification, and noncoding RNAs. Indeed, epigenetic events have been identified as an important pathophysiological determinant of FMF and co-factors shaping the clinical picture and outcome of the disease. Therefore, it is essential to better understand the contribution of epigenetic factors to autoinflammatory diseases, namely, FMF, to improve disease prognosis and potentially develop effective targeted therapies. In this review, we highlight the latest updates on the role of epigenetics in FMF.

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Critical Role of Gut Microbiota and Epigenetic Factors in the Pathogenesis of Behçet’s Disease

Cited by 9 publications

References 86 publications

The connection between epigenetics and gut microbiota‐current perspective

The connection between epigenetics and gut microbiota‐current perspective

A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide

Updates on the role of epigenetics in familial mediterranean fever (FMF)

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