UV/Visible Spectral Dissolution Monitoring by in Situ Fiber-Optic Probes

In Situ Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing

“…Spectroscopic in situ methods with fiber optics have been used to analyze the liquid phase, 13,14 but the analysis of the solid phase is more complicated. X-ray powder diffraction (XRPD) has been applied to measuring phase transformations on tablet surfaces during dissolution, 15 but there are major challenges, for example, difficulties in the in situ arrangements and high costs.…”

In-Situ Dissolution Testing Using Different UV Fiber Optic Probes and Instruments

“…Their work was extended thereafter to use six optical fibers and a PDA spectrometer for multiple dissolution vessels 3 . In 1995, Cho and coworkers developed a sevenchannel fiber optic dissolution system using a spectrometer with two-dimensional chargecoupled devices (CCD), which allowed the simultaneous monitoring of six dissolution vessels and a seventh reference vessel 4,5 . Several other studies around the same time further explored the possibility of using fiber optic technology for special dissolution applications.…”

In Situ Fiber-Optic Dissolution Assisted by a Mathematical Separation Model of Dynamic Three-Wavelength K-Ratio Spectrophotometry

“…Without automation, it is a labor-intensive process. The fiber-optic sensor based on ultraviolet-visible (UV-vis) absorption analysis for dissolution testing is a technique that has been under investigation for many years (1)(2)(3). Drug dissolution process analysis with fiber-optics uses a fiber-optic probe inserted directly into each vessel, and the absorbance of the solution is measured in situ instead of extracting samples and determining the concentration of active ingredient with UV spectrophotometry or high performance liquid chromatography (HPLC).…”