In-Situ Dissolution Testing Using Different UV Fiber Optic Probes and Instruments

In-line ATR-UV and Raman Spectroscopy for Monitoring API Dissolution Process During Liquid-Filled Soft-Gelatin Capsule Manufacturing

“…In recent years, advances in highquality optical fibers and sensitive array detectors have made in situ UV sampling and analysis possible by Bbringing the UV spectrometer to the sample^. This has greatly simplified sampling and improved analytical efficiency (17). Applications have been reported using fiber-optics based UV probes of different geometry for in situ dissolution testing and for testing the cleaning of manufacturing vessels (17)(18)(19)(20)(21)(22).…”

“…This has greatly simplified sampling and improved analytical efficiency (17). Applications have been reported using fiber-optics based UV probes of different geometry for in situ dissolution testing and for testing the cleaning of manufacturing vessels (17)(18)(19)(20)(21)(22). In these studies, transflectance or transmission probes were typically employed that can be inserted into the sample solution directly.…”

“…In these studies, transflectance or transmission probes were typically employed that can be inserted into the sample solution directly. The quality of UV measurements using such in situ transflectance/ transmission probes can be degraded by suspended particles and bubbles, although some of such interference may be overcome by operational changes and mathematical data treatment (17). Another limitation of such probes is that they are only suitable for the measurement of lower concentration samples, such as for drug product dissolution testing in aqueous media, because of the available pathlength of the probes.…”

Monitoring ibuprofen release from multiparticulates: In situ fiber-optic technique versus the HPLC method: A technical note

“…1 For a UV analytical method, a single-dissolution run could sometimes require an entire day to complete. The time for analysis is further increased when formulations require HPLC analysis.…”

“…A real-time drug release is determined in situ or in the vessels without sample removal, greatly simplifying the testing procedure. 1 Other than being an advantage to the in situ approach, the frequency of sampling (5 seconds to 2.5 minutes) is a great feature of fiber-optic monitoring systems. Data acquisition is fast and sampling can be done in a matter of seconds, leading to greater "data density" over time.…”