UV-Irradiation Depletes Antioxidants and Causes Oxidative Damage in a Model of Human Skin

Podda, Maurizio; Traber, Maret G.; Weber, C. W.; Lv, Yan; Packer, Lester

doi:10.1016/s0891-5849(97)00142-1

Cited by 228 publications

(146 citation statements)

References 29 publications

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“…Living cells are exposed to oxidants arising from external and internal sources. External sources include air pollutants, harmful gases (e.g., ozone), ionizing and nonionizing radiations, chemicals and toxins, and pathogenic bacteria and viruses (Menzal, 1994;Podda et al, 1998;Halliwell et al, 2000). Many childhood diseases have been linked with oxidative damage and has recently been reviewed (Granot et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial

Mahalanabis

Başak²,

Paul³

et al. 2006

Eur J Clin Nutr

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Objective: To evaluate the effect of antioxidant Vitamins E and C as adjunct therapy of severe acute lower respiratory infection (ALRI) in children. Design: Randomized double-blind placebo-controlled clinical trial. Setting: A large childrens' hospital serving the urban poor in Kolkata, India. Subjects: Children aged 2-35 months admitted with severe ALRI. Intervention: In total, 174 children were randomly assigned to receive a-tocopherol 200 mg and ascorbic acid 100 mg twice daily or placebo for 5 days. All children received standard treatment for severe ALRI. Outcome measures were: time taken to recover from a very ill status, fever, tachypnoea, and feeding difficulty; and improvement in oxidative stress and immune response indicated by thiobarbituric acid reacting substances (TBARS) and response to skin antigens, respectively. Results: Recovery rate ratios (95% CI) using proportional hazards model were 0.89 (0.64-1.25), 1.01 (0.72-1.41), 0.86 (0.57-1.29), and 1.12 (0.77-1.64) for very ill status, feeding difficulty, fever, and tachypnoea, respectively. TBARS values were high and similar in the two groups at admission, discharge, and at 2 weeks follow-up. Serum a-tocopherol significantly increased in treated group at discharge. Immune response to skin antigens were very poor at admission and after 2 weeks, in both groups. Conclusion: Infants with severe ALRI failed to benefit from two antioxidant nutrients as adjunct therapy. Severe ALRI in infants may cause cell-mediated immune dysfunction. We need a better understanding of oxidative processes in growing infants to help us better design interventions with antioxidant therapy.

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Section: Discussionmentioning

confidence: 99%

Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial

Mahalanabis

Başak²,

Paul³

et al. 2006

Eur J Clin Nutr

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“…In skin, the epidermis contains 10-fold higher Q10 than does the dermis. 5 The epidermis as the most outer layer of the skin is directly exposed to UV irradiation and other environmental factors, which makes it susceptible to depletion of skin antioxidants such as Q10; 6 therefore, the epidermis may represent a tissue that presumably benefits most from topically applied Q10. 3 CoQ10 can retard loss of hyaluronic acid and slowdown of cell division, both of which are manifestations of intrinsic aging.…”

Section: Introductionmentioning

confidence: 99%

Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies

Farboud¹,

Nasrollahi²,

Tabbakhi³

2011

IJN

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Solid lipid nanoparticles (SLNs) of coenzyme Q10 (CoQ10) were formulated by a high-pressure homogenization method. The best formulation of SLN dispersion consisted of 13% lipid (cetyl palmitate or stearic acid), 8% surfactant (Tween 80 or Tego Care 450), and water. Stability tests, particle size analysis, differential scanning calorimetry, transmission electron microscopy, and release study were conducted to find the best formulation. A simple cream of CoQ10 and a cream containing CoQ10-loaded SLNs were prepared and compared on volunteers aged 20–30 years. SLNs with particle size between 50 nm and100 nm exhibited the most suitable stability. In vitro release profiles of CoQ10 from simple cream, SLN alone, and CoQ10-loaded SLN cream showed prolonged release for SLNs compared with the simple cream, whereas there was no significant difference between SLN alone and SLN in cream. In vitro release studies also demonstrated that CoQ10-loaded SLN and SLN cream possessed a biphasic release pattern in comparison with simple cream. In vivo skin hydration and elasticity studies on 25 volunteers suggested good dermal penetration and useful activity of Q10 on skin as a hydratant and antiwrinkle cream.

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“…The second one is related to its toxicity. UV light causes progressive damage to human surrounded skin mediated by free radical generation 15 , destruction of vitamins A, 16 and C, 17,18 , collagen damage 19 and even worse genetic damage. 20 Therefore, systems able to respond to visible (Vis) light rather than to UV offer a less harmful alternative.…”

Section: Introductionmentioning

confidence: 99%

A novel visible light responsive nanosystem for cancer treatment

et al. 2017

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UV-Irradiation Depletes Antioxidants and Causes Oxidative Damage in a Model of Human Skin

Cited by 228 publications

References 29 publications

Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial

Antioxidant vitamins E and C as adjunct therapy of severe acute lower-respiratory infection in infants and young children: a randomized controlled trial

Novel formulation and evaluation of a Q10-loaded solid lipid nanoparticle cream: in vitro and in vivo studies

A novel visible light responsive nanosystem for cancer treatment

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