UV-Based Therapy

Totonchy, Mariam B.; Chiu, Melvin

doi:10.1016/j.det.2014.03.003

Cited by 36 publications

(52 citation statements)

References 129 publications

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“…The treatment decreased the body weight and gonad weight (testes and ovaries) thus indicating psoraleninduced reproductive toxicity (Takizawa et al, 2002). There are several reports on hepatotoxicity symptoms in mice and rats after long-term usage of psoralen or isopsoralen (Khushboo et al, 2010;Totonchy and Chiu, 2014;Wang et al, 2012). In an investigation, P. corylifolia and its natural compounds (bavachin, corylifol A, neobavaisoflavone, IBC, and BCN) were evaluated for their potential toxicity, and the results showed it had a potent inhibitory effect against human UDP-glucuronosyltransferase 1A1 (UGT1A1) which is considered a stimulant for P. corylifolia related toxicity, including hepatic injury and raised bilirubin levels .…”

Section: Side-effects and Toxicitymentioning

confidence: 99%

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Koul

Taak

Kumar

et al. 2019

Journal of Ethnopharmacology

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A B S T R A C TEthnopharmacological relevance: The genus Psoralea (Fabaceae) harbours 105 accepted species that are extensively used by local peoples and medicinal practitioners of China, India, and other countries for treatment of tooth decay, psoriasis, leucoderma, leprosy, kidney problems, tuberculosis, indigestion, constipation and impotence. Presently, pharmacological research reports are available on only few species namely Bituminaria bituminosa (Syn: P. bituminosa), P. canescens, P. corylifolia, P. esculenta, P. plicata and P. glandulosa which are valued for their chemical constituents and traditional uses. Aim of the review: This review article provides explicit information on traditional uses, phytochemistry, and pharmacological activities of selected Psoralea species. The possible trends and perspectives for future research on these plants are also discussed. Materials and methods: An extensive and systematic review of the extant literature was carried out, and the data under various sections were identified using a computerized bibliographic search via the PubMed, Web of Science and Google Scholar, CAB Abstracts, MEDLINE, EMBASE, INMEDPLAN, NATTS as well as several websites. Key findings: A total of 291 bioactive compounds from 06 species of genus Psoralea have been isolated and characterized. However, P. bituminosa alone possess nearly 150 compounds. These bioactive compounds belong to different chemical classes, including flavonoids, coumarins, furanocoumarins, chalcones, quinines, terpenoids and some others due to which these species exhibit significant anti-oxidant, anti-bacterial, anti-fungal, anti-viral, anti-helmintic, anti-diabetic, diuretic, hepatoprotective, anti-cancer and anti-tumor activities. P. corylifolia L. (Babchi), a Chinese traditional medicinal plant has been used in traditional medicine for many decades for its healing properties against numerous skin diseases such as leprosy, psoriasis and leucoderma. Conclusions: The in vitro studies and in vivo models have provided a simple bio-scientific justification for various ethnopharmacological uses of Psoralea species. From the toxicological perspective, the root, leaf, and seed extracts and their preparations have been proven to be safe when consumed in the recommended doses. But, meticulous studies on the pharmaceutical standardization, mode of action of the active constituents, and sustainable conservation of Psoralea species are needed, to meet the growing demands of the pharmaceutical industries, and to fully exploit their preventive and therapeutic potentials.

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Section: Side-effects and Toxicitymentioning

confidence: 99%

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Koul

Taak

Kumar

et al. 2019

Journal of Ethnopharmacology

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“…The use of BB‐UVB was a breakthrough therapeutic modality when it was introduced for the treatment of psoriasis (Totonchy and Chiu, ). However, later studies found that NB‐UVB clears psoriatic plaques faster and produces longer remissions than BB‐UVB does, thus establishing it as the phototherapeutic modality of choice for psoriasis (Lapolla et al , ).…”

Section: Disease‐specific Therapymentioning

confidence: 99%

Ultraviolet phototherapy for cutaneous diseases: a concise review

Vangipuram

Feldman

2015

Oral Diseases

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Phototherapy is the use of non‐ionizing radiation, primarily in the ultraviolet spectrum, to treat disease. In dermatology, ultraviolet (UV) phototherapy remains an established, lower cost, and often preferred option for many common skin conditions, despite the introduction of newer potent biologics. This article introduces a principal therapeutic modality in the treatment of psoriasis, atopic dermatitis (eczema), vitiligo, and morphea among other diseases where oral manifestations may be present, providing basic information about the use of UVA, UVB, and PUVA. Practical considerations and side effects of phototherapy are described. Phototherapy is an effective treatment for many illnesses and carries a relatively benign side‐effect profile.

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“…Many studies reporting the effects of light therapy on humans, in different pathological conditions, concern the irradiation by the application of ultraviolet (UV) lamp [1,2], infrared (IR) laser [3,4], Light Emitting Diode (LED) [5,6], and Polarized Polychromatic Incoherent Low Energy Radiation (PILER) [7][8][9][10][11]. All these sources showed light therapy exerts reparative capacity by modulating the production of cytokines and other soluble factors, and their main targets are fibroblasts from the skin [7].…”

Section: Introductionmentioning

confidence: 99%

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

Salmeri

Denaro

Ruello

et al. 2020

IJERPH

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(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluated by ELISA; (3) Results: Our results showed a decrease in the levels of pro-inflammatory IL-12p70, IL-17A, IFN-γ, and TNF-α cytokines, whereas IL-10 and TGF-β1 with regulatory activity increased; (4) Conclusions: PILER irradiation affected the cytokine production by isolated PBMCs driving the immune response toward an anti-inflammatory/reparative profile.

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UV-Based Therapy

Cited by 36 publications

References 129 publications

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Genus Psoralea: A review of the traditional and modern uses, phytochemistry and pharmacology

Ultraviolet phototherapy for cutaneous diseases: a concise review

Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

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