UV Absorption Spectroscopic Analysis of the Molecular Orientation of a Drug Penetrated into a DPPC Membrane

Hasegawa, Takeshi; Ushiroda, Yuko; Kawaguchi, Maki; Kitazawa, Yoshiko; Nishiyama, Miho; Hiraoka, and Aya; Nishijo, Jujiro

doi:10.1021/la950449j

Cited by 11 publications

(13 citation statements)

References 34 publications

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“…Nevertheless, despite these limitations, Beer's law for surface‐confined species is usually expressed as shown in Equation :

true Absorbance = 2 \times 1000 . ϵ . Γ with ({, \begin{matrix} ϵ, M^{- 1} {cm}^{- 1} \\ Γ, mol {cm}^{- 2} \end{matrix})

…”

Section: Resultsmentioning

confidence: 99%

“…Via the uniaxial refractive index ellipsoid model and by comparing the theoretical approach with experimental data, previous works have established that the transmission spectrum of a Langmuir‐Blodgett film or organic thin films depends on the tilt angle (α) of the immobilized chromophores, defined with respect to the surface normal direction. In considering these findings and assuming that all PDI species are oriented in the same direction and randomly distributed in the SAM (i. e. a crude approximation), the anisotropic values of extinction coefficient ϵ || and ϵ ⊥ (i. e. parallel and perpendicular projections to the surface normal direction, respectively) of 1 could be expressed as Equation

true ({, \begin{matrix} ϵ_{⊥} = \frac{3}{2} ϵ_{SAM} {prefixsin}^{2} (α) \\ ϵ_{∥} = 3 ϵ_{SAM} {prefixcos}^{2} (α) \end{matrix}) with ϵ_{SAM} : extinction coefficient in SAM

…”

Section: Resultsmentioning

confidence: 99%

“…Because ϵ SAM cannot be approximated by the molecular extinction coefficient of species in solution, a normalization at Γ=Γ max of equation 3 allows to extract an expression of α independent of ϵ SAM [Eq. ]:

true α ((), Γ) = \arcsin ([], prefixsin ([], α ((), Γ_{\max})) . \sqrt{\frac{Absorbance ((), Γ)}{Absorbance ((), Γ_{\max})} . \frac{Γ_{\max}}{Γ}})

…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Absorption Spectroelectrochemistry on Mixed Perylenediimide‐Based Self‐Assembled Monolayers: Non‐Linear Dependence of Absorbance versus Surface Coverage

et al. 2017

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The study of mixed self‐assembled monolayers of perylenediimide and hexanethiol by cyclic voltammetry and absorption spectroelectrochemistry shows a non‐linearity of absorbance maxima as a function of the surface coverage. This surprising result could be supported by an increase in the average tilt angle at low coverage, suggesting that the dilution of redox species through an alkanethiol would induce a change of the orientation of immobilized chromophores and, therefore, a modification of the optical properties of the monolayer.

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“…Nevertheless, despite these limitations, Beer's law for surface‐confined species is usually expressed as shown in Equation :

true Absorbance = 2 \times 1000 . ϵ . Γ with ({, \begin{matrix} ϵ, M^{- 1} {cm}^{- 1} \\ Γ, mol {cm}^{- 2} \end{matrix})

…”

Section: Resultsmentioning

confidence: 99%

true ({, \begin{matrix} ϵ_{⊥} = \frac{3}{2} ϵ_{SAM} {prefixsin}^{2} (α) \\ ϵ_{∥} = 3 ϵ_{SAM} {prefixcos}^{2} (α) \end{matrix}) with ϵ_{SAM} : extinction coefficient in SAM

…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Absorption Spectroelectrochemistry on Mixed Perylenediimide‐Based Self‐Assembled Monolayers: Non‐Linear Dependence of Absorbance versus Surface Coverage

et al. 2017

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“…Further thermodynamic and spectroscopic studies [234,235] provided evidence for drug insertion into the hydrophobic part of the membrane, however, without modification of the chain order, which is in contrast to the action observed for the above discussed anesthetics and anti-inflammatory drugs. The experiments revealed the predominant contribution of electrostatic interactions with PO 2 -groups associated with the disruption of hydrogen bonds at the phospholipid-water interface [234].…”

Section: Accepted Manuscriptmentioning

confidence: 92%

“…Typical examples include: antimicrobials [117,, anti-tumorals [116,, antiinflammatory [77,[214][215][216][217], anesthesics [218][219][220][221][222][223][224][225][226][227], anti-psychotics [228][229][230][231][232][233][234][235][236][237], cardiac [238][239][240][241][242][243][244][245] and antihistaminic [246] drugs. To address this issue, Langmuir monolayers have been used involving AmB alone as well as mixed with membrane sterols.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

et al. 2015

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A Porphyrin Spin Qubit and Its 2D Framework Nanosheets

Urtizberea

Natividad

Alonso

et al. 2018

Adv Funct Materials

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Molecular spin qubits have been shown to reach sufficiently long quantum coherence times to envision their use as hardware in quantum processors. These will however require their implementation in hybrid solid-state devices for which the controlled localization and homogeneous orientation of the molecular qubits will be necessary. An alternative to isolated molecules that can ensure these key aspects is 2D framework in which the qubit would act as node. In this work, it is demonstrated that the isolated metalloporphyrin [Cu(H 4 TCPP)] molecule is a potential spin qubit, and maintains similar quantum coherence as node in a 2D [{CuTCPP}Zn 2 (H 2 O) 2 ] metal-organic framework. Mono-and multilayer deposits of nanosheets of a similar 2D framework are then successfully formed following a modular method based on Langmuir-Schaefer conditions. The orientation of the {CuTCPP} qubit nodes in these nanosheets is homogeneous parallel to the substrate. These nanosheets are also formed with a control over the qubit concentration, i.e., by dilution with the unmetallated porphyrin. Eventually, 2D nanosheets are formed in situ directly on a substrate, through a simple protocol devised to reproduce the Langmuir-Schaefer conditions locally. Altogether these studies show that 2D spin qubit frameworks are ideal components to develop a hybrid quantum computing architecture. and gates first arose in the form of purely organic systems, using either the multiple nuclear spins of rationally selected molecules or the electronic spin(s) of open shell organic molecules bearing one or multiple radicals. The careful design and selection of such organic molecules coupled to sophisticated experiments have allowed implementing realistic quantum operations using ensembles of these. [2] Paramagnetic coordination complexes were later proposed as alternative molecular spin qubits, after it was argued and shown that the molecule electronic spin orientation and quantum superpositions allow to encode quantum bit (qubit) states. [3] Recent improvements in the coherence times of these molecular spin qubits [4] and the unique ability to design molecules with multiple qubits as prototypes of quantum gates [5] have brought this scheme to a point where it becomes reasonable to envision the design of a magnetic quantum processor. A magnetic molecule has even recently been used to implement Grover's quantum algorithm, albeit using its metal ion nuclear spin. [6] One of the advantages of the molecular scheme is that macroscopic numbers of identical qubits are obtained in one sole reaction. While this is appealing for the daunting challenge of scaling to a usable size, common to all proposed schemes, [7] the technology to build a scalable quantum architecture based on molecular qubits is

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UV Absorption Spectroscopic Analysis of the Molecular Orientation of a Drug Penetrated into a DPPC Membrane

Cited by 11 publications

References 34 publications

Absorption Spectroelectrochemistry on Mixed Perylenediimide‐Based Self‐Assembled Monolayers: Non‐Linear Dependence of Absorbance versus Surface Coverage

Absorption Spectroelectrochemistry on Mixed Perylenediimide‐Based Self‐Assembled Monolayers: Non‐Linear Dependence of Absorbance versus Surface Coverage

Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models

A Porphyrin Spin Qubit and Its 2D Framework Nanosheets

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