A flexible printed monopole antenna integrated with artificial magnetic conductor (AMC) working at 2.45 GHz is designed and analyzed. The proposed antenna is suitable for the industrial, scientific, and medical (ISM) band, WIFI and Bluetooth applications. The artificial magnetic conductor (AMC) is used to enhance the antenna characteristics and to isolate the antenna from human body effects that produces by proximity coupling. The antenna has ultra-low profile which is about 0.028 λ0. The simulated results show a good improvement in gain from 0.82 dB to 2.61 dB, efficiency from 78.56 % to 88.72% and the radiation pattern change from omni-direction to uni-direction which it suitable for wearable applications.