Utilizing the vascular occlusion technique with NIRS technology

Gerovasili, Vasiliki; Dimopoulos, Stavros; Tzanis, Georgios; Anastasiou-Nana, Maria; Nanas, Serafim

doi:10.1016/j.ergon.2009.02.004

Cited by 45 publications

(38 citation statements)

References 34 publications

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“…Ascent also appeared associated with unaltered basal oxygen consumption (Sto 2 downslope during occlusion) despite the presence of tissue hypoxia, but with impaired microcirculatory function (reduced Sto 2 upslope, Fig. 6)-Sto 2 upslope reflecting endothelium dependent vasodilation (Gerovasili et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

“…Vasodilatation begins during the ischemic occlusion phase such that when the cuff is released, there is a brief period of hyperemia, the magnitude of which is dependent of microcirculatory function (Neviere et al, 1996). Endothelial dysfunction thus results in slower reperfusion rates and therefore a reduced Sto 2 upslope (Gerovasili et al, 2010). We have previously demonstrated that ascent to high altitude is associated with a reduction in sublingual microcirculatory flow index (MFI) measured by sidestream dark field (SDF) imaging (Martin et al, 2009a(Martin et al, , 2010.…”

Section: Nirs-vot At High Altitudementioning

confidence: 99%

“…adipose accumulation and tissue edema (Gerovasili et al, 2010). Sto 2 was measured using a tissue spectrometer (InSpectra Model 325, Hutchinson Technology, MN, USA), fitted with a probe of 15 mm optode spacing, and was defined as the ratio of oxygenated to total haemoglobin concentration.…”

Section: Nirs-vot At High Altitudementioning

confidence: 99%

“…Skeletal muscle oxygenation can be measured by near infrared spectroscopy (NIRS) and, in combination with a noninvasive vascular occlusion test (VOT), provides a dynamic assessment of resting oxygen consumption and microvascular reactivity (Gerovasili et al, 2010). We hypothesized that adaptation to hypobaric hypoxia at high altitude (acclimatization) would result in i) reduced skeletal muscle oxygen consumption, and ii) impairment of the microcirculation, as assessed (respectively) by the decline in muscle oxygenation during a brief period of ischemia, and its rate of recovery upon cessation of the ischemic challenge.…”

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confidence: 99%

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The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude

Martin

Levett

Bezemer

et al. 2013

High Altitude Medicine & Biology

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Martin, Daniel, Denny Levett, Rick Bezemer, Hugh Montgomery, and Mike Grocott. The use of skeletal muscle near infrared spectroscopy and a vascular occlusion test at high altitude. High Alt Med Biol 14:256-262, 2013.-Microcirculatory function, central to tissue regulation of oxygen flux, may be altered by the chronic hypoxemia experienced at high altitude. We hypothesized that at high altitude, adaptations within skeletal muscle would result in reduced oxygen consumption and reduced microcirculatory responsiveness, detectable by near infrared spectroscopy (NIRS) during a vascular occlusion test (VOT). The VOT comprised 3 min of noninvasive arterial occlusion; thenar eminence tissue oxygenation (Sto 2 ) was measured by NIRS during the VOT at sea level, 4900 m and 5600 m (after 7 and 17 days at altitude, respectively) in 12 healthy volunteers. Data were derived from Sto 2 time-curves using specifically designed computer software. Mean ( -SD) resting Sto 2 was reduced at 4900 m and 5600 m (69.3 ( -8.2)% ( p = 0.001) and 64.2 ( -6.1)% ( p < 0.001) respectively) when compared to sea level (84.4 ( -6.0)%. The rate of Sto 2 recovery after vascular occlusion (Sto 2 upslope) was significantly reduced at 4900 m (2.4 ( -0.4)%/sec) and 5600 m (2.4 ( -0.8)%/sec) compared to sea level (3.7 ( -1.3)%/sec) ( p = 0.021 and p = 0.032, respectively). There was no change from sea level in the rate of desaturation during occlusion (Sto 2 downslope) at either altitude. The findings suggest that in resting skeletal muscle of acclimatizing healthy volunteers at high altitude, microvascular reactivity is reduced (Sto 2 upslope after a short period of ischemia) but that oxygen consumption remains unchanged (Sto 2 downslope).

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Section: Discussionmentioning

confidence: 99%

Section: Nirs-vot At High Altitudementioning

confidence: 99%

Section: Nirs-vot At High Altitudementioning

confidence: 99%

mentioning

confidence: 99%

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The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude

Martin

Levett

Bezemer

et al. 2013

High Altitude Medicine & Biology

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“…Recently, near-infrared spectroscopy (NIRS) in combination with vascular occlusion testing (VOT) has emerged as an easily applicable, non-invasive measure of tissue oxygenation (Gerovasili et al 2010). Immediately after an ischaemic challenge, the NIRS-derived tissue oxygen saturation (S tO 2 ) signal rapidly increases.…”

Section: Introductionmentioning

confidence: 99%

Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status

McLay

Gilbertson

Pogliaghi

et al. 2016

Experimental Physiology

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Edited by: Philip J. Atherton New Findings r What is the central question of this study?Is the near-infrared spectroscopy-derived measure of tissue oxygen saturation (S tO 2 ) reperfusion slope sensitive to a range of ischaemic conditions, and do differences exist between trained and untrained individuals? r What is the main finding and its importance?The S tO 2 reperfusion rate is sensitive to different occlusion durations, and changes in the reperfusion slope in response to a variety of ischaemic challenges can be used to detect differences between two groups. These data indicate that near-infrared spectroscopy-derived measures of S tO 2 , specifically the reperfusion slope following a vascular occlusion, can be used as a sensitive measure of vascular responsiveness.The reperfusion rate of near-infrared spectroscopy-derived measures of tissue oxygen saturation (S tO 2 ) represents vascular responsiveness. This study examined whether the reperfusion slope of S tO 2 is sensitive to different ischaemic conditions (i.e. a dose-response relationship) and whether differences exist between two groups of different fitness levels. Nine healthy trained (T; age 25 ± 3 years; maximal oxygen uptake 63.4 ± 6.7 ml kg −1 min −1 ) and nine healthy untrained men (UT; age 21 ± 1 years; maximal oxygen uptake 46.6 ± 2.5 ml kg −1 min −1 ) performed a series of vascular occlusion tests of different durations (30 s, 1, 2, 3 and 5 min), each separated by 30 min. The S tO 2 was measured over the tibialis anterior using near-infrared spectroscopy, with the S tO 2 reperfusion slope calculated as the upslope during 10 s following cuff release. The reperfusion slope was steeper in T compared with UT at all occlusion durations (P < 0.05). For the T group, the reperfusion slopes for 30 s and 1 min occlusions were less than for all longer durations (P < 0.05). The reperfusion slope following 2 min occlusion was similar to that for 3 min (P > 0.05), but both were less steep than for 5 min of occlusion. In UT, the reperfusion slope at 30 s was smaller than for all longer occlusion durations (P < 0.05), and 1 min occlusion resulted in a reperfusion slope that was less steep than following 2 and 3 min (P < 0.05), albeit not different from 5 min (P > 0.05). The present study demonstrated that the reperfusion rate of S tO 2 is sensitive to different occlusion durations, and that changes in the reperfusion rate in response to a variety of ischaemic challenges can be used to detect differences in vascular responsiveness between trained and untrained groups.

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Oxygenation dynamics of sepsis patients undergoing far‐infrared intervention based on near‐infrared spectroscopy

Chuang

Sia

et al. 2016

Journal of Biophotonics

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Near-infrared spectroscopy (NIRS; continuous wave type) is a noninvasive tool for detecting the relative change of oxyhemoglobin and deoxyhemoglobin. To make this change, intervention methods must be applied. This study determined the hemodynamics of 44 healthy participants and 35 patients with sepsis during exposure to FIR as a novel physical intervention approach. Local microcirculation of their brachioradialis was monitored during exposure and recovery through NIRS. The variations in blood flow and microvascular reaction were determined by conducting paired and unpaired t tests. The oxyhemoglobin levels of the healthy participants increased continuously, even during recovery. In contrast to expextations, the oxyhemoglobin levels of the patients plateaued after only 5 min of FIR illumination. The proposed method has potential applications for ensuring efficient treatment and facilitating doctors in diagnosing the functions of vessels in intensive care units. Mapping diagrams of HbO in healthy males and males with sepsis illustrated unique scenarios during the process.

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Utilizing the vascular occlusion technique with NIRS technology

Cited by 45 publications

References 34 publications

The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude

The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude

Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status

Oxygenation dynamics of sepsis patients undergoing far‐infrared intervention based on near‐infrared spectroscopy

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