Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment

Loewenstein, David; Curiel, Rosie E.; DeKosky, Steven T.; Bauer, Russell M.; Rosselli, Mónica; Guinjoan, Salvador M.; Adjouadi, Malek; Peñate, Ailyn; Barker, William; Goenaga, Sindy; Golde, Todd E.; Greig‐Custo, Maria T.; Hanson, Kevin; Li, Chunfei; Lizarraga, Gabriel; Marsiske, Michael; Duara, Ranjan

doi:10.1212/wnl.0000000000006128

Cited by 58 publications

(73 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, none of the selected studies in the current metaanalysis had Aβ or Tau biomarkers of AD in MCI participants, but this represents a very interesting research perspective in future studies. For instance, a recent study by Loewenstein et al (Loewenstein et al, 2018), showed that a test of semantic interference, the LASSI-L, was able to FaR Facilitated Recall, FrR Free recall, N Naming Fig. 3 Comparison of the effect size across the different types of tasks: facilitated recall of semantic information (cued recall or multiple-choice questions), free recall of semantic information and naming single entities.…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment

et al. 2020

View full text Add to dashboard Cite

Accumulating evidence over the past decade suggests that semantic deficits represent a consistent feature of Mild Cognitive Impairment (MCI). A meta-analysis was performed to examine if semantic deficits are consistently found in patients with MCI. Studies meeting all inclusion criteria were selected for the current meta-analysis. An effect size and a weight were calculated for each study. A random effect model was performed to assess the overall difference in semantic performances between MCI patients and healthy subjects. 22 studies (476 healthy participants, 476 MCI patients, mean Mini Mental Status Examination of the MCI patients: 27.05 ± 0.58) were included in the meta-analysis. Results indicate that MCI patients systematically performed significantly worse than healthy matched controls in terms of overall semantic performance (mean effect size of 1.02; 95% CI [0.80; 1.24]). Semantic deficits are a key feature of MCI. Semantic tests should be incorporated in routine clinical assessments.

show abstract

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Semantic intrusions are designed to be readily triggered on the LASSI-L because of the administration of two semantically related learning lists, and they are one of the primary challenges associated with the test. Difficulties in monitoring previously encoded information and in retrieval may underlie the production of intrusions (17). Furthermore, in some cases, the patients deliberately produced semantic intrusions using a strategy similar to the generation of a categorical verbal fluency in order to mask their absence of recall of the list.…”

Section: Discussionmentioning

confidence: 99%

“…Proper assessment therefore measures learning, response to cues, and adequately taps both proactive and retroactive interference. There is increasing evidence that semantic interference tasks may be more sensitive to detect subtle memory deficits and underlying brain dysfunction than traditional memory assessments (17).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the LASSI-L captures several memory processes, including encoding, storage and learning, free and cued recall, delayed recall, proactive and retroactive interference and, uniquely, the ability to recover from the effects of proactive semantic interference (18). The LASSI-L is a challenging and more demanding task than traditional cognitive assessments (17). Thus, it has been considered as a "cognitive stress test, " allowing the detection of more subtle memory deficits than is possible with other tools.…”

Section: Introductionmentioning

confidence: 99%

“…The LASSI-L scores examining the different memory processes can be compared and checked against each other, and thus, they could be interpreted independently from demographic factors, which may represent an advantage in the absence of normative data (22). In addition, the test elicits frequent semantic intrusion errors, which have shown to detect biomarkers including amyloid positivity in the context of amnestic mild cognitive impairment (17). Although the LASSI-L was developed and validated for the early detection of Alzheimer's disease, this paradigm could also be particularly important in the setting of MS, which impairs young people in working age with strong memory requirements in daily living.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Memory Impairment in Relapsing-Remitting Multiple Sclerosis Using a Challenging Semantic Interference Task

et al. 2020

Self Cite

View full text Add to dashboard Cite

Objective: Episodic memory is frequently impaired in Multiple Sclerosis (MS), but the cognitive characteristics and neuropsychological processes involved remain controversial. Our aim was to study episodic memory dysfunction in MS, using the LASSI-L, a novel memory-based cognitive stress test that uses a new paradigm that capitalizes on semantic interference.Methods: Cross-sectional study in which 93 patients with MS (relapsing-remitting) and 124 healthy controls were included. The LASSI-L test was administered to all participants, as well as a comprehensive neuropsychological battery including a selective reminding test. MS patients were divided into two groups, with cognitive impairment (CI-MS) and cognitively preserved (CP-MS).Results: Reliability of the LASSI-L test was high (Cronbach's alpha 0.892) and there were less ceiling effects. MS patients scored lower than controls on all LASSI-L subtests, except for maximum storage of the initial target items (CRA2). Effect sizes were moderate-large. A delay in learning, difficulties in retroactive semantic interference, failure to recover from proactive semantic interference, and delayed recall were the most frequent findings in MS patients. Scores associated with maximum storage capacity, and retroactive semantic interference were the most strongly associated with cognitive impairment and employment status. Conclusion:We found that deficits in maximum learning, difficulties in recovery from the effects of proactive semantic interference and retroactive semantic interference are three important breakdowns in episodic memory deficits among patients with MS. The LASSI-L showed good psychometric and diagnostic properties. Overall, our study supports the utility of the LASSI-L, as a new cognitive test, useful for neuropsychological assessment in MS in clinical and research settings.

show abstract

Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia

DeSimone,

Wang,

Loewenstein

et al. 2024

Alzheimer's & Dementia

Self Cite

View full text Add to dashboard Cite

INTRODUCTIONMagnetic resonance imaging (MRI) biomarkers are needed for indexing early biological stages of Alzheimer's disease (AD), such as plasma amyloid‐β (Aβ42/40) positivity in Aβ positron emission tomography (PET) negative individuals.METHODSDiffusion free‐water (FW) MRI was acquired in individuals with normal cognition (NC) and mild cognitive impairment (MCI) with Aβ plasma‐/PET‐ (NC = 22, MCI = 60), plasma+/PET‐ (NC = 5, MCI = 20), and plasma+/PET+ (AD dementia = 21) biomarker status. Gray and white matter FW and fractional anisotropy (FAt) were compared cross‐sectionally and the relationships between imaging, plasma and PET biomarkers were assessed.RESULTSPlasma+/PET‐ demonstrated increased FW (24 regions) and decreased FAt (66 regions) compared to plasma‐/PET‐. FW (16 regions) and FAt (51 regions) were increased in plasma+/PET+ compared to plasma+/PET‐. Composite brain FW correlated with plasma Aβ42/40 and p‐tau181.DISCUSSIONFW imaging changes distinguish plasma Aβ42/40 positive and negative groups, independent of group differences in cognitive status, Aβ PET status, and other plasma biomarkers (i.e., t‐tau, p‐tau181, glial fibrillary acidic protein, neurofilament light).Highlights Plasma Aβ42/40 positivity is associated with brain microstructure decline. Plasma+/PET‐ demonstrated increased FW in 24 total GM and WM regions. Plasma+/PET‐ demonstrated decreased FAt in 66 total GM and WM regions. Whole‐brain FW correlated with plasma Aβ42/40 and p‐tau181 measures. Plasma+/PET‐ demonstrated decreased cortical volume and thickness.

show abstract

Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment

Cited by 58 publications

References 47 publications

A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment

A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment

Memory Impairment in Relapsing-Remitting Multiple Sclerosis Using a Challenging Semantic Interference Task

Diffusion MRI relates to plasma Aβ42/40 in PET negative participants without dementia

Contact Info

Product

Resources

About