Utilizing neutron generators in boron neutron capture therapy

Metwally, Walid A.; Alharahsheh, Y.; Dalah, Entesar Zawam; Al-Omari, H.

doi:10.1016/j.apradiso.2021.109742

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…The semi-major and semi-minor axes of the assumed head phantom were set to 9.76 cm and 7.77 cm, respectively, following the Geant4 human phantom example [51]. The skin layer had a thickness of 0.8 cm [36], while the skull layer was 0.65 cm thick [62]. The tumor and its surrounding vicinity were approximated as spheres.…”

Section: Tumor's Size and Depth In A Head Phantom And Boron Dose Enha...mentioning

confidence: 99%

“…These studies suggested delivering the tumor with a non-toxic neutron capture agent with high concentrations of boron or gadolinium compared with the surrounding tissues. The thermal neutron capture interactions with 10 B (BNCT) and 157 Gd (GdNCT) isotopes resulted in charged particles with high LET which enhances the dose delivered to the targeted tumor [35][36][37][38]. Delivering an agent containing boron to the tumor adds an additional modality enhancing the proton therapy.…”

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confidence: 99%

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Optimization of a therapeutic laser accelerated proton beam at 94.8 MeV for Stereotactic Radiosurgery

Omari,

Yahia,

Almomani

et al. 2023

Preprint

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Recent advances in laser-accelerated proton technology have unveiled potential applications for Stereotactic Radiosurgery. In this study, we present a beamline simulation designed by TraceWin and SRIM codes to optimize the spectral and spatial properties of a laser-driven proton beam. The simulation incorporates four quadrupoles for beam focusing, an energy selection aperture aided by a cylindrical on-axis absorber, a scatterer, and an angular selection aperture for energy smoothing and collimation. By optimizing the beamline configuration, we have achieved a uniform beam with dose rates surpassing even those utilized in FLASH radiotherapy, allowing the delivery of high doses to millimeter-scale volumes within nanosecond timescales. To validate the efficacy of our beamline for therapeutic applications of radiosurgery, we conducted another comprehensive simulation study on the irradiation of a hypothetical tumor in a head phantom using Geant4 and FLUKA Monte Carlo-based codes. The results demonstrate that the downstream protons exhibit a narrow energy spread of 94.8 ± 3.9 MeV and a homogenized lateral profile with a possible proton dose of 0.022 J/kg at the center of the tumor. The study also included the Boron dose enhancement and secondary radiation environment. By leveraging laser-accelerated protons instead of cyclotrons, our unique platform offers a precise and relatively cost-effective infrastructure for a laser-accelerated proton beam Stereotactic Radiosurgery.

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Section: Tumor's Size and Depth In A Head Phantom And Boron Dose Enha...mentioning

confidence: 99%

mentioning

confidence: 99%

Optimization of a therapeutic laser accelerated proton beam at 94.8 MeV for Stereotactic Radiosurgery

Omari,

Yahia,

Almomani

et al. 2023

Preprint

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“…Previous studies have confirmed that the surface of MXene has polyhydroxy and negatively charged surface, which endowed MXene with high reducing capacity; therefore, there was no need for adding an additional reducing agent to the hydrothermal reaction. During the hydrothermal reaction, there were two reactions between MXene and Gd(NO 3 ) 3the oxidation reaction of MXene ( 2) and the reduction reaction of Gd (NO 3 ) 3 (3). However, only the total content of the product of the hydrothermal reaction could be calculated from the XPS data, and the content of the two components of the reaction product corresponded to Gd(OH)CO 3 and Gd 2 O 3 could not be calculated.…”

Section: The Composition Ratio and Reaction Mechanism Of Gd@mxenementioning

confidence: 99%

“…In particular, neutron rays have shown a wide range of applications in energy, 1 military, 2 and medical fields. 3 However, continual exposure to neutron radiation can many diseases such as cancer, leukemia, and cataracts. 4 Thus, the personnel in the above fields, such as radiology nuclear plant workers, doctors, and aircraft crews, are more vulnerable to nuclear radiation.…”

Section: Introductionmentioning

confidence: 99%

Constructing oriented two-dimensional fish scale-like Gd@MXene barrier walls in polyvinyl alcohol to achieve excellent neutron shielding properties

2022

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“…At present, as a successful method in the field of NCT, boron neutron capture therapy (BNCT) has been emerge in clinical trials, it was widely used to treat gliomas, head and neck cancers, urological cancers, and so on [2][3][4][5]. After the nonradioactive isotope 10 B-based drugs enter the tumor tissue and enrich the tumor cells, Low-energy thermal neutrons induce a reaction with 10 B, resulting in the release of α particles (track lengths approximately 9 µm in cell) and recoil lithium particles (track lengths approximately 5 µm in cell), accompanied by a small amount of γ rays, the energies of the emitted particles are 1.78 MeV (6.3%) or 1.47 MeV (93.7%) for α particles, 1.01 MeV (6.3%) or 0.84 MeV (93.7%) for 7 Li particles, and 0.48 MeV for gamma rays [6][7][8][9]. The produced particles of BNCT deposit energy in the nucleus of the tumor and selectively destroys the DNA helix [9][10].…”

Section: Introductionmentioning

confidence: 99%

A Monte Carlo study of the Cellular Dosimetry for SNCT Comparison with MIRD S Values

Zhang,

Lan,

Jiang

et al. 2023

Preprint

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Background An interesting isotope, sulfur-33 (a stable isotope), has been proposed as an additional neutron capture or a cooperating target for enhancing boron neutron capture therapy. Recently, 33S was considered as the substitute for boron-10 in neutron capture radiotherapy. The 33S (n, α)30Si reaction emits the α particles useful for neutron capture therapy. Based on the Monte Carlo method, we investigated the dosimetric characteristics of the cellular model of several geometries for the sulfur-33 neutron capture therapy (SNCT). Methods Monte Carlo N-Particle (MCNP) was used for simulating the transport of α particles emitted by SNCT from the cellular model surface (CS), cytoplasm (Cy), or nucleus (N) of a single cell model. The model cells were defined as two concentric spheres consisting of the nucleus and cytoplasm. The radius of the cell model was Rc=6 µm Rn=3 µm. The S values (SC←C, SC←CS, SN←N, SN←Cy, SN←CS) were compared to the results with the Medical Internal Radiation Dosimetry (MIRD) method. Finally, S values of the cellular model of several geometries were calculated. Results The relative differences of MCNP versus MIRD method S values for SNCT ranged from 0.28% to 4.29% for C to C (SC←C), -2.82% to 0.05% for Cs to C (SC←Cs), 0.54% to 4.42% for N to N (SN←N), 0.72% to 3.14% for Cy to N (SN ←Cy), and -1.76% to 0.36% for CS to N (SN←CS). The ratios of SN←N/ SC←C, SN←CS/SC←C, SN←Cy/ SC←C decreased with increasing the cell and nucleus size. Conclusion The S value simulated by MCNP is in agreement with the MIRD method, which is proved to be reliable for the cellular dosimetry of SNCT by the Monte Carlo method. The Model Carlo method can be used instead of the MIRD method to accurately calculate cellular S values, which solves the problem of cell shape limitation in MIRD method (which is suitable for regular spherical cellular model).

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Utilizing neutron generators in boron neutron capture therapy

Cited by 5 publications

References 7 publications

Optimization of a therapeutic laser accelerated proton beam at 94.8 MeV for Stereotactic Radiosurgery

Optimization of a therapeutic laser accelerated proton beam at 94.8 MeV for Stereotactic Radiosurgery

Constructing oriented two-dimensional fish scale-like Gd@MXene barrier walls in polyvinyl alcohol to achieve excellent neutron shielding properties

A Monte Carlo study of the Cellular Dosimetry for SNCT Comparison with MIRD S Values

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