Utilizing Guar Gum for Development of “Tabs In Cap’ System of Losartan Potassium for Chronotherapeutics

Gangwar, Guarav; Kumar, Anil; Pathak, Kamla

doi:10.1016/j.ijbiomac.2014.09.027

Cited by 12 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Title Coating technology used Core material Coating composition Drug Ref A novel system for three-pulse drug release based on “tablets in capsule” device Solvent evaporation Capsule body Ethyl Cellulose EC, DMT Diclofenac Li et al., 2007 In vitro evaluation of once a day chronotherapeutic drug delivery system of Gymnema sylvestre Spray coating and dip coating Tablet and pellets Hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) 600 and HPMC phthalate-50, PEG 600 Gymnema sylvestre Jaina and Devi, (2016) Formulation and pharmacokinetics of colon-specific double-compression coated mini-tablets: Chronopharmaceutical delivery of ketorolactromethamine Double compression Tablets HPMC K100M, Eudragit S100 Ketorolactromethamine Kunal et al., 2012 In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog Press coating Tablet Glyceryl behenate, L-Hydroxy Propyl Cellulose (HPC) Theophylline Ghimire et al. (2007) Utilizing guar gum for development of “tabs in cap’ system of losartan potassium for chronotherapeutics Dip coating Capsule body Ethyl cellulose, dibutyl phthalate (DP) Losartan potassium Gangwar et al. (2015) A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers Spray coating Capsule body Organic ethylcellulose (Ethocel 1; 100 premium grade), triacetin Theophylline McConville et al.…”

Section: Application Of Coating To Chronotherapeuticsmentioning

confidence: 99%

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Gowthami

Krishna

Rao

2021

Current Research in Pharmacology and Drug Discovery

View full text Add to dashboard Cite

In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertension and rheumatoid arthritis, etc. They require prompt release of drug as per the disease condition, which can be achieved by programmed lag time. Chronotherapeutic drug delivery systems (CDDS) can be achieved by several methods, coating is one amongst them. Though the coating process is complex in terms of methodology, solubility issues and difficulty in achieving the uniform coating, many researchers were successfully employed in development of CDDS. A scientific prospection was made from 2010 to 2020 using PubMed database. Apart from exploration of publication data, we attempt to brief about classification of patents and concordance. The scrutiny also highlights the patents filed on chronotherapeutic systems, focusing particularly on coating technologies. The review is concluded the successful application of coating technology to develop CDDS, as evident from vast number of publications and patents filed.

show abstract

Section: Application Of Coating To Chronotherapeuticsmentioning

confidence: 99%

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Gowthami

Krishna

Rao

2021

Current Research in Pharmacology and Drug Discovery

View full text Add to dashboard Cite

show abstract

“…Other researchers have tested the controlled release of mesalazine from 'tablets in capsule' systems for the targeted release of the drug in the colon area [9,20,21]. 'Tablets in capsule' system formulations have also been tested for biphasic release of one drug substance [20,22,23], or more [24,25]. Also, in the study of [26] 'tablets in capsule' systems were tested in vivo for their ability to float in the stomach for more than 4h.…”

Section: Comparison Between the Excipients Dextran And Pectinmentioning

confidence: 99%

Investigation of a Novel “Tablets in Capsule” Theophylline Formulation System for Modified Release

Vlachou¹,

Siamidi²,

Efentakis³

2017

PPIJ

View full text Add to dashboard Cite

In pharmaceutical research, new dosage forms that modify drug release are useful for circadian rhythm related diseases. The aim of this investigation is to examine the release behavior of multiple-unit modified-release formulations ('tablets in capsule') of theophylline. Mono-layered and three-layered minitablets, filled into capsules, were prepared using theophylline and dextran or pectin, as excipients. Their release behavior was compared with respect to powder filled capsules and the commercially available Theodur® 200 mg tablets. Dissolution tests were performed in three pH media (1.5, 7.4 and 6.0) in the presence and absence of the enzyme Pectinex® Ultra SP-L solution, which degrades polysaccharides. The results indicate that enteric-coated capsules showed no drug release, in the first two hours in the acidic media. Dextran produces a thicker gelled layer than pectin and therefore, dextran based 'tablets in capsules' systems are suitable as a model extended release formulation. The drug is released from 3-layered minitablets at a slower rate compared to matrix minitablets. The product, Pectinex® Ultra SP-L, was found to give more accurate dissolution results when used as an additive to the media, mimicking the large intestine/colon area especially when the formulations target this region.

show abstract

“…A variety of design strategies have been attempted for pulsatile release purposes; including; solid lipid microparticles (Albertini et al 2014) , pellets (Zhang et al 2014) , osmotically-controlled capsules (Ranjan et al 2014), membrane rupture systems (Lin et al 2008), time-controlled explosion systems (Ueda et al 1994) , tabs-in-cap systems (Gangwar et al 2015), mini-tablets (Biswas et al 2014), press coated tablets (Shah et al 2015), Chronotropic systems (Gazzaniga et al 1994) and core-in-cup dry coated tablets (Efentakis et al 2011, Efentakis et al 2006.…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetic Evaluation of a Chronotherapeutic System Loaded With an Antiasthmatic Drug as an Oral Drug Delivery System

Elbatanony

2016

Al-Azhar Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Recent studies proved that the symptoms of bronchial asthma follow the circadian rhythms and become worse in the early morning. In such cases, conventional sustained-release treatment regimens are inappropriate for the delivery of antiasthmatic drugs as they cannot be administrated just prior to the worsening of the symptoms. The current work aimed to explore the pharmacokinetics of a model antiasthmatic drug following oral administration of a chronotherapeutic system in six healthy volunteers. A sensitive and selective chromatoghraphic method was used to determine drug concentration in human plasma. A standard calibration curve of the drug over the concentration range of 0.15-80 µg/ml was prepared in human plasma. Anhydrous caffeine was used as an internal standard. The protocol of the studies was approved by the Research Ethics Committee for clinical studies at Faculty of Pharmacy, Cairo University, Egypt. Following oral administration of the treatments, the pharmacokinetic parameters of the drug including C max (µg/ml) , T max (h), MRT (0-∞) , (h), AUC 0-24 (µg h/ml) and AUC 0-∞ (µg h/ml) were derived from the individual plasma concentration time curves. The data were statistically analyzed using two-way ANOVA at P < 0.05. The results confirmed that the drug reached C max rapidly within two hours following a definite lag time; confirming the potential of the developed chronotherapeutic system in promoting the drug absorption at its site of action at the required time.

show abstract

Utilizing Guar Gum for Development of “Tabs In Cap’ System of Losartan Potassium for Chronotherapeutics

Cited by 12 publications

References 13 publications

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents

Investigation of a Novel “Tablets in Capsule” Theophylline Formulation System for Modified Release

Pharmacokinetic Evaluation of a Chronotherapeutic System Loaded With an Antiasthmatic Drug as an Oral Drug Delivery System

Contact Info

Product

Resources

About