Utilization of pomegranate peel waste: Natural deep eutectic solvents as a green strategy to recover valuable phenolic compounds

Bertolo, Mirella Romanelli Vicente; Martins, Virgínia da Conceição Amaro; Plepis, Ana Maria G.; Bogusz, Stanislau

doi:10.1016/j.jclepro.2021.129471

Cited by 23 publications

(16 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To recover active components from agro-industrial wastes or convert those wastes into a wide range of bio-based products based on the biorefinery concept, NADES have been employed in a number of studies and shown an advantageous potential to utilize the biowastes. In the study of Bertolo et al (2021) , NADES were used as alternative solvents to recover the phenolic compounds from the pomegranate peel waste. Under optimal extraction conditions, the phenolic recovery rate with ChCl and LA was increased by 54.6%, when compared with the non-optimized conditions, and by 84.2%, when compared with the ethanolic extraction.…”

Section: Prospects Of Future Applications For Nades In Chms and Chall...mentioning

confidence: 99%

Applications for natural deep eutectic solvents in Chinese herbal medicines

Rao

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Chinese herbal medicines (CHMs), with a wide range of bioactive components, are considered to be an important source for new drug discovery. However, the process to isolate and obtain those bioactive components to develop new drugs always consumes a large amount of organic solvents with high toxicity and non-biodegradability. Natural deep eutectic solvents (NADES), a new type of green and designable solvents composed of primary plant-based metabolites, have been used as eco-friendly substitutes for traditional organic solvents in various fields. Due to the advantages of easy preparation, low production cost, low toxicity, and eco-friendliness, NADES have been also applied as extraction solvents, media, and drug delivery agents in CHMs in recent years. Besides, the special properties of NADES have been contributed to elucidating the traditional processing (also named Paozhi in Chinese) theory of CHMs, especially processing with honey. In this paper, the development process, preparation, classification, and applications for NADES in CHMs have been reviewed. Prospects in the future applications and challenges have been discussed to better understand the possibilities of the new solvents in the drug development and other uses of CHMs.

show abstract

Section: Prospects Of Future Applications For Nades In Chms and Chall...mentioning

confidence: 99%

Applications for natural deep eutectic solvents in Chinese herbal medicines

Rao

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…It was previously reported that the variability and dependency of the viscosity of these NADESs are significantly influenced by the intermolecular interactions between HBDs and HBAs [42]. The NADESs have higher viscosities than conventional solvents due to the hydrogen bond, Van der Waals, and electrostatic interactions between the components, which constrict their usage in the extraction of bioactive compounds due to mass transfer delay [43]. As a result, all the NADESs were screened as a mixture made by mixing the NADES with additional water in a 25% (v/v) ratio.…”

Section: Evaluation Of Piperine Using Nades Extractionmentioning

confidence: 99%

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology

Lwamba

Aboushanab

Ambati

et al. 2023

Sustainable Chemistry

View full text Add to dashboard Cite

Bioactive compounds like piperine (alkaloids) offer a variety of health benefits due to their biological and pharmacological potential. Piperine has been revealed to have anti-inflammatory, anti-aging, anti-diabetes, anti-bacterial, anti-ulcer, and anti-carcinogenic characteristics. Recent research has been conducted to extract piperine using effective and environmentally friendly techniques. In this study, we sought to assess the potential and efficacy of natural deep eutectic solvents to extract piperine from black pepper seeds using an ultrasound-assisted extraction technique. A Box–Behnken design combined with response surface methodology was used to evaluate the optimum extraction conditions of piperine. Extraction efficiency was evaluated based on the extraction yields of piperine, antioxidant activity, total polyphenols, and total flavonoids. The results showed that the choline chloride-citric acid-1,2-propylene glycol combination (1:2:2 molar ratio) with 25% (v/v) of water was the most effective at extracting piperine from black pepper. It was found that the extraction yield of piperine was significantly influenced by the liquid–solid ratio and extraction time. The optimal extraction conditions were determined and it was found that antioxidant activities and total polyphenol content in the piperine-rich extracts were remarkably related to the piperine content. The piperine extract purity was found to be 90%. Our results indicate that black pepper could be used as a functional food application.

show abstract

“…After the ultrasound treatment, the extracts were centrifuged at 10,000 rpm for 10 min (Centrifuge 5424 R, Eppendorf, Hamburg, Germany), and stored at −8 °C protected from light. 16 For means of comparison, the same extractions were conducted by applying an ethanolic solution (60%, v/v) as solvent. The ethanolic extracts were subjected to the same steps as the ones obtained with NADES.…”

Section: Screening Of Nades For the Extraction Of Phenolicmentioning

confidence: 99%

“…The results of pH and density found for the prepared solvents agree with those reported in a previous study, in which all of the NADES also presented 20% of water in their composition: CC-CIT was also the densest NADES (∼1.63 g mL −1 ) with the lowest pH, while the ethanolic solution was closer to pH 7.0 and the least dense solvent (∼1.14 g mL −1 ). 16 The polarity of a solvent influences the amounts, as well as the profile of the phenolic compounds extracted from different materials. The NADES polarity was evaluated and compared to the ethanolic solution using the solvatochromic method based on the Nile Red dye, which measures the shifts of the maximum absorbance wavelength according to the solvent in which the dye is diluted.…”

Section: Nades Preparation and Characterizationmentioning

confidence: 99%

Green Strategies for Recovery of Bioactive Phenolic Compounds from Agro-Industrial Wastes (Pomegranate Peels, Almond Hulls, and Elderberry Pomace) Using Natural Deep Eutectic Solvents

Bertolo,

Bogusz Junior,

Mitchell

2023

ACS Food Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Natural deep eutectic solvents (NADES) based on choline chloride and organic acids were applied for the recovery of phenolic compounds from three agro-industrial residues: pomegranate peels, almond hulls, and elderberry pomace. Box–Behnken designs were conducted to reach the best extraction conditions, which were 50 °C, 20 min, and 20 w/w NADES/solid for pomegranate peels, 30 °C, 60 min, and 20 w/w NADES/solid for almond hulls, and 40 °C, 60 min, and 30 w/w NADES/solid for elderberry pomace. Punicalagin was the major phenolic in the NADES-based pomegranate extract, with a concentration about 87% higher than that found in the ethanolic extract obtained under the same conditions. The same was valid for (+)-catechin, a major phenolic in almond extracts, and cyanidin-3-sambubioside, a major anthocyanin in elderberry extracts, with concentrations around 27 and 68% higher in the NADES extracts, respectively. These findings show that the extraction of valuable compounds from agro-industrial waste using NADES was improved with accuracy during ultrasound-assisted extractions.

show abstract

Utilization of pomegranate peel waste: Natural deep eutectic solvents as a green strategy to recover valuable phenolic compounds

Cited by 23 publications

References 33 publications

Applications for natural deep eutectic solvents in Chinese herbal medicines

Applications for natural deep eutectic solvents in Chinese herbal medicines

Innovative Green Approach for Extraction of Piperine from Black Pepper Based on Response Surface Methodology

Green Strategies for Recovery of Bioactive Phenolic Compounds from Agro-Industrial Wastes (Pomegranate Peels, Almond Hulls, and Elderberry Pomace) Using Natural Deep Eutectic Solvents

Contact Info

Product

Resources

About