Utilization of Fourier transform-Raman spectroscopy for the study of pharmaceutical crystal forms

Findlay, W. Paul; Bugay, David E.

doi:10.1016/s0731-7085(97)00058-7

Cited by 84 publications

(41 citation statements)

References 13 publications

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“…One of the strongest bands of menthone, the one corresponding to the C=O stretching mode, appears as a weak band at 1708 cm , which seems to be related to CH3/CH2 bending modes of menthol. Based on the Raman spectrum of a supersaturated solution of menthol in ethanol reported by Findlay and Bugay [53], the strong band at 769 cm −1 can be attributed to menthol. Taking into account the spectral region, the band at 769 cm do not appear in the Raman spectra of menthone and menthol, they could be attributed to minor components.…”

Section: Resultsmentioning

confidence: 95%

Handheld Raman Spectroscopy for the Distinction of Essential Oils Used in the Cosmetics Industry

Jentzsch

Ramos²,

Ciobotă³

2015

Cosmetics

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Essential oils are highly appreciated by the cosmetics industry because they have antimicrobial and antioxidant properties, among others. Since essential oils are natural products, their inclusion in cosmetic formulations is a common practice. Currently, low-quality and/or adulterated essential oils can be found on the market; therefore, analytical methods for control are required. Raman spectroscopy is a versatile technique that can be used for quality control tasks; the portability of modern devices expand the analytical possibilities also to in situ measurements. Fifteen essential oils of interest for the cosmetics industry were measured using a handheld Raman spectrometer, and the assignment of the main bands observed in their average spectra was proposed. In most cases, it is possible to distinguish the essential oils by a simple visual inspection of their characteristic Raman bands. However, for essential oils extracted from closely-related vegetable species and containing the same main component in a very high proportion, the visual inspection of the spectra may be not enough, and the application of chemometric methods is suggested. Characteristic Raman bands for each essential oil can be used to both identify the essential oils and detect adulterations. OPEN ACCESSCosmetics 2015, 2 163

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Section: Resultsmentioning

confidence: 95%

Handheld Raman Spectroscopy for the Distinction of Essential Oils Used in the Cosmetics Industry

Jentzsch

Ramos²,

Ciobotă³

2015

Cosmetics

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“…Raman and infrared spectroscopy have been employed to investigate pharmaceutical crystal forms (2,4,12). Due to the different ordering of atoms in the crystal lattice, each crystal form generally has different Raman and infrared spectra.…”

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confidence: 99%

Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Jednačak¹,

Hodžić²,

Scheibelhofer³

et al. 2014

Acta Pharmaceutica

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Many active pharmaceutical ingredients (APIs) are small organic molecules that have different polymorphic forms (1). It is well known that the API's polymorphic form can affect its physico-chemical properties, such as density, melting point, solubility, stability, morphology and bioavailability (2). Thus, polymorphic screening is a critical part of preformulation studies. The search for possible polymorphic forms typically begins with crystallization of a drug substance from various solvents, including those frequently used during the final crystallization steps (3, 4). Since the API's physicochemical properties can have a dramatic impact on its therapeutic effect, it is crucial to detect the polymorphic form with the characteristics appropriate for the intended use. For this purpose, the parameters affecting the crystallization process should be controlled and optimized (5). Major limitations to improving the control of crystallization parameters Crystallization of the drug entacapone from binary solvent mixtures was monitored in situ using a Raman optical probe. The recorded Raman spectra and statistical analysis, which included the principal components method and indirect hard modeling made it possible to estimate the starting point of crystallization, to assess crystallization temperatures and to provide information on the polymorphic content of the mixture. It was established that crystallization temperatures were proportional to the volume content of the solvent in mixtures. The samples were also evaluated off-line via Raman spectroscopy and SWAXS. The collected data showed the presence of forms b and g in all solvent mixtures. In a toluene/methanol 30:70 mixture, in addition to forms b and g, at least one of the forms A, D or a was also indicated by SWAXS. The results have shown that the presence of a particular polymorph is strongly dependent on the nature and portion of the solvent in the binary solvent mixture.

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“…Of the water soluble vitamins, thiamine B 1 , niacin B 3 , also known as nicotinic acid and nicotinamide, pyridoxine B 6 and ascorbic acid (C) were considered.…”

Section: Vitaminsmentioning

confidence: 99%

Identification and characterization of pharmaceuticals using Raman and surface‐enhanced Raman scattering

Pinzaru

Pavel

Leopold

et al. 2004

J Raman Spectroscopy

129

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Many recent papers reflect ongoing research and development concerning pharmaceutical applications of Raman techniques. This short review highlights different Raman techniques (dispersive, Fourier transform, resonance Raman, SERS, SERRS, FT-SERS) employed in pharmaceutical investigations. Several Raman applications such as fundamental structural investigations, quantitative analysis, drug-excipient interaction, formulation, limit of detection, pH-dependent pharmaceutical species, adsorption geometry at a given surface and functional groups involved in adsorption for several widely used pharmaceutical compounds are presented.

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Utilization of Fourier transform-Raman spectroscopy for the study of pharmaceutical crystal forms

Cited by 84 publications

References 13 publications

Handheld Raman Spectroscopy for the Distinction of Essential Oils Used in the Cosmetics Industry

Handheld Raman Spectroscopy for the Distinction of Essential Oils Used in the Cosmetics Industry

Fast real-time monitoring of entacapone crystallization and characterization of polymorphs via Raman spectroscopy, statistics and SWAXS

Identification and characterization of pharmaceuticals using Raman and surface‐enhanced Raman scattering

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