Utilization of core wash material in the diagnosis of breast lesions by stereotactic needle biopsy

Lankford, Krista V.; Kluskens, Larry; Dowlatshahi, Kambiz; Reddy, Vijaya B.; Gattuso, Paolo

doi:10.1002/(sici)1097-0142(19980425)84:2<98::aid-cncr5>3.0.co;2-9

Cited by 10 publications

(6 citation statements)

References 6 publications

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“…Therefore, core wash cytology was selected as the way of diagnosing cytology in this study. Core wash cytology of breast lesions diagnosed by stereotactic needle biopsy was reported by Lankford et al [10]. The reported sensitivity and specificity were 85% and 98%, and the rate of unsatisfactory specimens was 7% in 211 lesions.…”

Section: Discussionmentioning

confidence: 89%

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Core wash cytology of breast lesions by ultrasonographically guided core needle biopsy

Uematsu

Kasami

2007

Breast Cancer Res Treat

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Previous studies demonstrated that core wash cytology by stereotactic needle biopsy was useful for the immediate diagnosis of breast lesions. The purpose of this study was to assess the accuracy of core wash cytology of breast lesions by ultrasonographically (US) guided core needle biopsy (CNB). US-guided 18-gauge CNB was performed in a series of 458 cases. Each CNB sample was washed in saline solution. Core wash cytology of the washed core material was performed on material obtained by saline solution lavage of the fragments using a cytocentrifuge. The cytological diagnoses were divided into five categories: benign, atypical/indeterminate, suspicious/probably malignant, malignant, and unsatisfactory, which then were compared with the CNB results. The cytological diagnoses of the 458 cases were as follows: 106 lesions (23.1%) were benign, 28 lesions (6.1%) were atypical/indeterminate, 42 lesions (9.2%) were suspicious/probably malignant, 88 lesions (19.2%) were malignant, and 194 lesions (42.4%) were unsatisfactory. The core wash cytology had a sensitivity of 89% (141 of 158), and a specificity of 72% (76 of 106). The CNB showed 143 of 194 unsatisfactory samples (74%) to be benign, three to be high-risk, and 48 (25%) to be malignant. Unsatisfactory samples were obtained from significantly more benign than malignant lesions. In conclusion, the high rate of insufficient samples for core wash cytology of breast lesions by US-guided CNB makes its use impractical in this setting. This technique is not useful for immediate diagnosis of breast lesions by US-guided CNB.

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Section: Discussionmentioning

confidence: 89%

“…One is core imprint cytology [4,5,8,9], and the other is core wash cytology [10]. Several studies have shown that breast core imprint cytology is a reliable predictor of CNB, with values for sensitivity ranging from 86-97% and for specificity from 78-100% [4,5,8,9].…”

Section: Discussionmentioning

confidence: 99%

Core wash cytology of breast lesions by ultrasonographically guided core needle biopsy

Uematsu

Kasami

2007

Breast Cancer Res Treat

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“…One older study describes similar diagnostic results: 7% inadequate samples on CWC and a sensitivity and specificity of 85 and 98%, respectively [1]. Of note, Lankford et al used a larger (16 gauge) core needle, while the 18 gauge needle we used may be more comfortable for the patient.…”

Section: Literature Cwcmentioning

confidence: 68%

“…Unfortunately, the results described in the literature with such cytological diagnostic approaches are variable. In studies on CWC the sensitivity and specificity varied from 85% to 89% and 72% to 98%, respectively, while the inadequate rate varied from 7% to 42% [1,2]. Studies on TIC showed variable results as well [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 94%

Modified core wash cytology (CWC), an asset in the diagnostic work-up of breast lesions

Wauters

Sanders-Eras

Heijden

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Manuscript category Original Article Condensed AbstractThe modified core wash cytology procedure is a valuable tool for obtaining a rapid diagnosis from core needle biopsies of breast lesions. 2 AbstractAim: A quick and reliable preliminary diagnosis is essential in the management of a sameday breast clinic. In a preclinical study we developed an alternative method of core wash cytology (CWC). This study is an evaluation of this new CWC method introduced into the clinical setting.Methods: From April 2008 to April 2009, biopsies were taken from lesions in the breast.CWC was obtained from core needle biopsy (CNB) with a modified technique and classified into the categories: malignant, suspicious for malignancy, atypical, benign and inadequate.CWC and CNB diagnoses were correlated with the histopathology of subsequently obtained resection specimens. The sensitivity and specificity were calculated.Results: CWC was obtained from 226 breast lesions. In 167 of these cases subsequent resection of the lesion was performed revealing 149 carcinomas and 18 benign lesions.Of the 149 malignant cases, 136 were considered as either malignant or suspicious for malignancy by CWC, 7 as atypical, 4 as benign and 2 as inadequate. None of the 18 benign lesions were classified as suspicious or malignant on CWC. Eight out of 149 resected carcinomas were not recognized as malignant by histological analysis of the CNB, while 7 of these cases the CWC was considered malignant. The sensitivity and specificity were 97% and 100%, respectively. Conclusions:In the vast majority of patients the modified CWC technique can provide a quick and reliable diagnosis of malignant breast lesions. Furthermore, combining CWC with CNB histology can improve adequate, preoperative recognition of the malignant character of breast lesions.

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“…[90,91] In a prospective study of 236 benign and 210 malignant cases, Uematsu and Kasami found 42% of CW samples to be inadequate (C1). Therefore, they concluded that CW is not useful for same-day diagnosis of breast lesions.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Preoperative cytological and histological diagnosis of breast lesions: A critical review

Kooistra

Wauters

Strobbe

et al. 2010

European Journal of Surgical Oncology (EJSO)

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Statement of expertiseThe first author, BK, has recently published several papers on fine needle aspiration, core needle biopsy and nipple discharge cytology. CW is an experienced pathologist and cytopathologist with special scientific interest in the position the diagnostic pathology in preoperative work-up of breast lesions. LS is a breast surgeon with special interest in preoperative work-up and has supervised several research projects on this subject in the past years. The senior author, TW, is an experienced professor in surgical oncology with special interest in diagnosis and surgical treatment of breast pathology. Key wordsBreast pathology; fine needle aspiration; core needle biopsy; core wash cytology; touch imprint cytology; breast surgery.

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Utilization of core wash material in the diagnosis of breast lesions by stereotactic needle biopsy

Cited by 10 publications

References 6 publications

Core wash cytology of breast lesions by ultrasonographically guided core needle biopsy

Core wash cytology of breast lesions by ultrasonographically guided core needle biopsy

Modified core wash cytology (CWC), an asset in the diagnostic work-up of breast lesions

Preoperative cytological and histological diagnosis of breast lesions: A critical review

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