Utilization of B12 for the treatment of chronic migraine

Urits, Ivan; Yilmaz, Melis; Bahrun, Ehab; Merley, Caitlin; Scoon, Logan; Lassiter, Grace; An, Daniel; Orhurhu, Vwaire; Kaye, Alan D.; Viswanath, Omar

doi:10.1016/j.bpa.2020.07.009

Cited by 7 publications

(5 citation statements)

References 61 publications

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“…Dietary folate information was collected from all participants and analyzed using the "FoodWorks" 2009 package [36]. The results from this study indicate that folate intake in the form of FA may in uence migraine frequency in female migraine with aura (MA) sufferers [36].Supplementation of folic acid with pyridoxine could decrease the characteristics of migraine attacks including headache severity and attack frequency [37].A case-control study recruited 70 migraine patients and 70 healthy controls, utilizing enzyme-linked immunosorbent assay (ELISA) to measure serum vitamin B12 levels [38].The serum B12 levels in migraine patients were signi cantly lower than those in the healthy population, and individuals with lower functional activity of vitamin B12 had a higher likelihood of suffering from migraines [38].In terms of mechanisms, vitamin B12 plays a crucial role in restraining elevated homocysteine levels and excessive nitric oxide production,and a de ciency in B12 can result in disruptions to methionine metabolism [39].Vitamin B12 functions in the central nervous system, and a de ciency in this vitamin can give rise to detrimental neurological effects.Thus,Vitamin B12 has been used clinically for the prevention of migraines [40].…”

Section: Discussionmentioning

confidence: 99%

Association between Oxidative Balance Score and Migraine among American Adults: National Health and Nutrition Examination Survey

Su,

Wang,

Wang

et al. 2024

Preprint

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Background Oxidative stress has been observed to be linked with migraines. The oxidative balance score (OBS) serves as a metric for evaluating the overall systemic oxidative stress status, where elevated OBS scores suggest increased exposure to antioxidants. However, the precise connection between OBS and migraines has not been reported to date. This study seeks to investigate the potential association between OBS and migraine occurrences. Methods A cohort of 7,238 participants from the National Health and Nutrition Examination Survey (NHANES) spanning the years 1999 to 2004 was selected for this study. Migraine diagnoses were ascertained using the Patient Health Questionnaire, specifically asking participants if they had experienced a severe headache or migraine in the past three months.The Oxidative Balance Score (OBS) was determined based on the evaluation of 20 dietary and lifestyle factors. Logistic regression and restricted cubic splines (RCS) were employed to examine the association between OBS and migraines. Additionally, adjusted models were scrutinized in the analysis. Results The prevalence of migraine was 19.43%. There was a significant negative linear relationship between OBS, dietary OBS and migraine (p for nonlinear > 0.05). Compared to the lowest tertile of OBS, the adjusted ORs for the highest tertile of OBS and dietary OBS and migraine were 0.72(95% CI: 0.59 ~ 0.88), 0.70 (95% CI: 0.56 ~ 0.86) respectively, and all P for trend < 0.05. Compared to the lowest tertile of OBS, the adjusted ORs for the highest tertile of lifestyle OBS and migraine was 0.97 (95% CI:0.82 ~ 1.14), and all P for trend > 0.05. Limitations: This research was cross-sectional design, and it was not possible to deduce causality. Conclusions Diet and lifestyle might influence migraine by modulating oxidative balance. Antioxidant diets and lifestyles were important in reducing migraine and our study also provided new ideas for improving migraine.

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Section: Discussionmentioning

confidence: 99%

Association between Oxidative Balance Score and Migraine among American Adults: National Health and Nutrition Examination Survey

Su,

Wang,

Wang

et al. 2024

Preprint

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“…More vitamin B12 intake caused lower odds of migraine, while higher EPA levels induced higher odds of migraine. Previous studies indicated that the high level of homocysteine was the cause of migraine, and B vitamins, especially vitamin B12, catalyzed homocysteine and therefore were beneficial for migraine prevention ( Shaik et al, 2014 ; Urits et al, 2020 ). In addition, a recent systematic review showed that patients with migraine presented with a higher level of homocysteine and a lower level of folate, which also confirmed a relationship between B vitamins and migraine pathogenesis ( Liampas et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

Zheng

Shi²,

Liang³

et al. 2023

Front. Pharmacol.

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Objective: To examine the causal effect of potentially modifiable risk factors contributing to migraine pathogenesis.Methods: We performed Mendelian randomization analyses and acquired data from United Kingdom Biobank, FinnGen Biobank, and the MRC IEU OpenGWAS data infrastructure. An inverse-variance weighted (IVW) model was used to examine the relationship between 51 potentially modifiable risk factors and migraine in 3215 participants with migraine without aura (MwoA), 3541 participants with migraine with aura (MwA), and 176,107 controls. We adopted a Bonferroni-corrected threshold of p = 9.8 × 10–4 (.05 divided by 51 exposures) as a sign of significant effect, and a p < .05 was considered as the sign of a suggestive association.Results: More years of schooling significantly correlated with lower odds of MwoA pathogenesis (OR .57 [95%CI .44 to .75], p < .0001). More vitamin B12 intake (OR .49 [95%CI .24 to .99], p = .046) and lower level of stress [OR 8.17 (95%CI 1.5 to 44.36), p = .015] or anxiety disorder (OR 1.92 × 109 [95%CI 8.76 to 4.23*1017], p = .029) were suggestive to be correlated lower odds of MwoA pathogenesis. More coffee intake (OR .39 [95%CI .22 to .7], p = .001), lower level of eicosapentaenoic acid status (OR 2.54 [95%CI 1.03 to 6.26], p = .043), and more light physical activity (OR .09 [95%CI .01 to .94], p = .046) were suggestive to be associated with lower odds of MwA.Conclusion: The years of schooling, light physical activity, vitamin B12 intake, and coffee intake were the protective factors for migraine; stress, anxiety, and eicosapentaenoic acid status were harmful factors. Interventions could be developed based on modifying these factors for migraine prophylaxis.

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“…Further, individuals who suffer from migraines may have an increased risk of developing vitamin B12 deficiency due to the use of non-steroidal anti-inflammatory drugs for acute symptom relief and an increased incidence of active H. pylori infection [ 61 ]. In their article, Urits et al describe that many individuals with migraines also experience gastro-intestinal damage, and H. pylori infection further impairs vitamin B12 absorption by destroying gastric parietal cells and reducing the availability of intrinsic factors [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

et al. 2023

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(1) Background: The correlation between infection with Helicobacter pylori (H. pylori) and headache has been argued and explored for a long time, but a clear association between the simultaneous presence of the two in children has not been established yet. In this study, we aimed to explore this relationship in children from the Northeast region of Romania. (2) Methods: A retrospective study exploring the correlation between children having H. pylori infection and headache or migraine was conducted on a batch of 1757 children, hospitalized over 3 years in a pediatric gastroenterology department in Northeast Romania. (3) Results: A total of 130 children of both sexes had headache. From 130 children, 54 children (41.5%) also presented H. pylori infection. A significant association between headache and H. pylori infection (χ2; p < 0.01) was noticed. (4) Conclusions: More studies are needed on this relationship, and we emphasize the importance of further analyses, as they present great clinical importance for both prompt diagnosis and treatment.

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Utilization of B12 for the treatment of chronic migraine

Cited by 7 publications

References 61 publications

Association between Oxidative Balance Score and Migraine among American Adults: National Health and Nutrition Examination Survey

Association between Oxidative Balance Score and Migraine among American Adults: National Health and Nutrition Examination Survey

Modifiable factors for migraine prophylaxis: A mendelian randomization analysis

Helicobacter pylori Infection in Children: A Possible Reason for Headache?

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