Utilization of 2-nitrophenols in annulations with aryl isothiocyanates towards the synthesis of 2-aminobenzoxazoles

Abstract

A general method to afford 2-aminobenzoxazoles by the annulation of 2-nitrophenols with aryl isothiocyanates is firstly reported. The tolerance of an array of useful functionalities is observed.

Cobalt ferrite nanoparticles for annulation of C3-substituted nitroarenes and aryl isothiocyanates

“…5 The use of such nitroarenes avoids the pre-functionalization of ortho C–H bonds to nitroarenes prior to cyclization. 6 It should also be noted that elemental sulfur is often essential to promoting the transformations of N , N -dialkyl-3-nitroanilines. 7 As previous reports suggested that the C–H bonds ortho to nitro groups and para to N , N -dialkylamino groups are nucleophilic enough to react with sulfur-containing electrophiles, herein we report our attempts to develop a method for the cyclization of N , N -dialkyl-3-nitroanilines with aryl isothiocyanates.…”