Review of synthesis process of benzoxazole and benzothiazole derivatives

El Alami, Abouelhaoul; El Maraghi, Amine; Sdassi, Hamid

doi:10.1080/00397911.2024.2337089

Synthetic Communications

2024

DOI: 10.1080/00397911.2024.2337089

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Review of synthesis process of benzoxazole and benzothiazole derivatives

Abouelhaoul El Alami,

Amine El Maraghi,

Hamid Sdassi

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2024

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Cited by 2 publications

References 66 publications

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Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

Purawarga Matada,

Pal

et al. 2024

European Journal of Medicinal Chemistry

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Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

Purawarga Matada,

Pal

et al. 2024

European Journal of Medicinal Chemistry

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Development of In-Water Scalable Process for the Preparation of [2-(3-Bromo-2-methylphenyl)-7-chloro-1,3-benzoxazol-5-yl]methanol, a Key Intermediate in the Synthesis of Potent PD-1/PD-L1 Inhibitors

Prueksaritanont,

Rattanangkool,

Srisa

et al. 2024

Synlett

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We propose a synthetic process for the preparation of a benzoxazole building block for a programmed death-ligand 1 inhibitor that is a candidate currently under clinical investigation for cancer treatment. Our research focused on searching for mild, scalable, and ecofriendly conditions for the synthesis of benzoxazoles. To reduce the use of toxic reagents or solvents and to minimize the production of organic wastes, the cyclization reaction was performed in an aqueous micellar medium. This in-water benzoxazole synthesis gave comparable yields to previously reported processes, and was applied to a broad range of benzoxazoles with various substitution patterns, showcasing its effectiveness in ecofriendly benzoxazole cyclization reactions.

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Review of synthesis process of benzoxazole and benzothiazole derivatives

Cited by 2 publications

References 66 publications

Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

Benzothiazole a privileged scaffold for Cutting-Edges anticancer agents: Exploring drug design, structure-activity relationship, and docking studies

Development of In-Water Scalable Process for the Preparation of [2-(3-Bromo-2-methylphenyl)-7-chloro-1,3-benzoxazol-5-yl]methanol, a Key Intermediate in the Synthesis of Potent PD-1/PD-L1 Inhibitors

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