Utility of Y- and X-STRs in the research of complex biological relationship

Builes, J.J.; Manrique, A.; Aguirre, D.; Puerto, Yamirka González; Bravo, M.L.J.; Gusmão, Leonor

doi:10.1016/j.fsigss.2009.08.142

Cited by 5 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, many studies built and validated panels of STRs markers on the X chromosome (X-STR markers) to be used in forensic genetics, usually employing polymerase chain reaction (PCR) multiplexes ranging from six to 12 STR per reaction [3][4][5][6][7][8]. Such panels have been useful in complex relatedness cases when [9][10][11] (1) the putative father was not available, (2) the relatives were consanguineous, (3) the relative of the putative father is either his mother or daughter, and (4) in maternity investigation of a son [12].…”

Section: Introductionmentioning

confidence: 99%

Extensive survey of 12 X-STRs reveals genetic heterogeneity among Brazilian populations

Ribeiro-Rodrigues

Palha

Bittencourt³

et al. 2011

Int J Legal Med

View full text Add to dashboard Cite

The admixed Brazilian population shows high levels of genetic variability, which resulted from the contribution of three main ethnicities, Amerindian, European, and African. However, due to its huge territory, admixing has been asymmetrical, i.e., the relative contribution from each ethnicity has been unequal in the five geopolitical regions of the country. The aim of this study was to describe genetic variability using a panel of short-tandem repeats on the X chromosome (X-STR) in order to perform a comprehensive evaluation of the usefulness of such markers for forensic purposes in Brazil. Twelve X-STR (DXS9895, DXS7132, DXS6800, DXS9898, DXS6789, DXS7133, GATA172D05, DXS7130, HPRTB, GATA31E08, DXS7423, and DXS10011) were chosen and tested in a sample of 2,234 individuals belonging to 16 out of the 27 Brazilian States, representing all of its five geopolitical regions. No markers showed significant deviation from the Hardy-Weinberg equilibrium, even when analyses were partitioned to represent geopolitical regions. Genetic diversity per locus ranged from 67% (DSX7133) to 95% (DXS10011), and the State of Ceará showed the highest average genetic diversity (79% for all 12 X-STR markers). Considering the Brazilian population as a whole, the power of discrimination of the 12 X-STR panel in females (PDF) was 0.999999999999994, while the power of discrimination in males (PDM) was 0.9999999969. Such high values suggest the potential of that panel to be used in forensic applications and relatedness tests among individuals. Comparisons among the Brazilian populations investigated revealed significant differences when they were compared among each other, a pattern that was maintained when additional populations from Europe and Latin America were compared to Brazilians. Our results highlight the need and usefulness of specific genetic database for forensic purposes in Brazilian populations.

show abstract

Section: Introductionmentioning

confidence: 99%

Extensive survey of 12 X-STRs reveals genetic heterogeneity among Brazilian populations

Ribeiro-Rodrigues

Palha

Bittencourt³

et al. 2011

Int J Legal Med

View full text Add to dashboard Cite

show abstract

“…X-STR haplotyping can be of particular help in kinship testing with deficient paternity cases where a DNA sample from one of the parents is not available for testing. For example, if a father/daughter parentage relationship is in question, X-STRs may be helpful [53][54][55][56][57].…”

Section: X-chromosomal Strs and Ministrs: Identity Testing And Beyondmentioning

confidence: 99%

Scope of X-Chromosomal MiniSTRs: Current Developments

Israr¹

2014

J Forensic

View full text Add to dashboard Cite

The experience of using autosomal short-length amplicon STRs or miniSTRs in profiling of degraded DNA and mass disaster victims is extended into the realm of X-chromosomal (ChrX) STR miniaturization. About half of the total X-STRs are now short-length amplicons and the focus is shifting to using the mini versions of all of them. Joint multiplexing of these loci can be used for solving complex paternity cases and association of mass disaster victims with their families. This technology may herald a new dimension for research in population genetics and evolution. We present an overview of the progress made thus far and the future scope and prospects for X-miniSTRs.

show abstract

Utility of ForenSeq™ DNA Signature Prep Kit in the research of pairwise 2nd-degree kinship identification

et al. 2019

Int J Legal Med

View full text Add to dashboard Cite

Utility of Y- and X-STRs in the research of complex biological relationship

Cited by 5 publications

References 6 publications

Extensive survey of 12 X-STRs reveals genetic heterogeneity among Brazilian populations

Extensive survey of 12 X-STRs reveals genetic heterogeneity among Brazilian populations

Scope of X-Chromosomal MiniSTRs: Current Developments

Utility of ForenSeq™ DNA Signature Prep Kit in the research of pairwise 2nd-degree kinship identification

Contact Info

Product

Resources

About