Utility of the AD8 as a Self-Rating Tool for Cognitive Impairment in an Asian Population

Abstract

Within a transcultural setting, the p-AD8 demonstrated good discriminative validity and can be used to gain a preliminary understanding of an individual's cognitive status.

Early symptoms of Alzheimer's disease in Japan and Taiwan

“…AD8 is used extensively in screening dementia worldwide with the same cut‐off value, but the reported symptoms for dementia, presented as AD8 subitems, can vary between countries . We have found the most frequently reported symptom for very mild dementia was consistent problems with thinking and memory in Taiwan (89.3%), which was significantly different from that in Japan where forgetting the correct month or year was the frequently reported symptom (82.7%).…”

“…A strength of the present study was that we reported the symptoms frequently experienced and reported by informants or caregivers of AD patients, especially at the very mild stage. The cut‐off value of the AD8 is the same in discriminating dementia, including the very mild stage, from non‐dementia in various races, but the frequency of reported subitems in different stages of dementia were different in relation to cultural background . To our knowledge, the present study was the first one to compare the differences of reported symptoms in AD with various stages and non‐demented individuals in Japan and Taiwan.…”

“…Unfortunately, the questionnaire did not specify the symptoms of AD at the very mild stage, AD with Clinical Dementia Rating scale (CDR) 0.5. Another screening tool, Ascertain Dementia 8 (AD8), was developed at Washington University, and is capable of screening AD with higher sensitivity and specificity, even at its early stage, CDR 0.5; it has been extensively used and validated in several versions . In other words, AD8 can screen AD at its very mild stage with high sensitivity and specificity; these reported symptoms in the AD8 questionnaire could be the early symptoms of AD.…”

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

“…Of these, the Ascertain Dementia 8 (AD8) is an informant-based screening tool, which also may be useful in patients with MCI. 31–34 The items in the AD8 address memory, temporal orientation, judgment, and function. It has a sensitivity of 85% and specificity of 92%.…”

Screening for Dementia in Older Adults: Comparison of Mini-Mental State Examination, Mini-Cog, Clock Drawing Test and AD8

“…There are several dementia screening tools that would screening dementia early in the disease course, such as Mini-Mental State Examination (MMSE) [13], Mini-Cog [14], Clock Drawing Test (CDT) [15]and the Ascertain Dementia 8 questionnaire (AD8) [16]. MMSE, the most commonly used instrument, shows education and language/cultural bias[17] and is impractical[18] because it takes at least of 10 minutes to complete[19].…”