Early symptoms of <scp>A</scp>lzheimer's disease in <scp>J</scp>apan and <scp>T</scp>aiwan

Yang, Yuan Han; Hsu, Chia Ling; Chou, Mei Chuan; Kasai, Mari; Meguro, Kenichi; Liu, Ching Kuan

doi:10.1111/ggi.12557

Cited by 11 publications

(22 citation statements)

References 27 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…23,24 Furthermore, individuals with AD often offer alternative explanations for such symptoms, which can prevent family members from recognizing the symptoms as characteristic of AD. 23,24 Most families first notice AD progression when the patient shows violently intense behavioral and psychological symptoms of dementia, up to which point the family's lack of concern might have allowed AD to progress. 23,24 The present results might have been influenced by such lack of concern.…”

Section: Discussionmentioning

confidence: 99%

“…23,24 Most families first notice AD progression when the patient shows violently intense behavioral and psychological symptoms of dementia, up to which point the family's lack of concern might have allowed AD to progress. 23,24 The present results might have been influenced by such lack of concern. In summary, we showed that a greater improvement in scores is associated with lower HDS-R and MMSE scores at the first visit.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, specific symptoms of AD might prevent patients, especially those who are younger and highly educated, from accepting medical care. The individuals with AD and their families attribute such symptoms to normal aging or they do not recognize the symptoms . Furthermore, individuals with AD often offer alternative explanations for such symptoms, which can prevent family members from recognizing the symptoms as characteristic of AD .…”

Section: Discussionmentioning

confidence: 99%

“…The individuals with AD and their families attribute such symptoms to normal aging or they do not recognize the symptoms . Furthermore, individuals with AD often offer alternative explanations for such symptoms, which can prevent family members from recognizing the symptoms as characteristic of AD . Most families first notice AD progression when the patient shows violently intense behavioral and psychological symptoms of dementia, up to which point the family's lack of concern might have allowed AD to progress .…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Medical interventions suppressed progression of advanced Alzheimer's disease more than mild Alzheimer's disease

Honjo¹,

Ide

Takechi

2020

Geriatrics Gerontology Int

View full text Add to dashboard Cite

Aim Alzheimer's disease (AD) is the most common neurodegenerative disease. In 2000, Mendiondo et al. reported on a model predicting that AD progresses at an accelerating rate and cognitive function worsens rapidly. Recently, anti‐AD drugs and non‐pharmacological intervention have been established, but the effect of intervention is unclear and might depend on the stage of AD progression. Here, we examined the prediction of Mendiondo's model in patients with different severities of AD. Methods A total of 163 new outpatients with AD at four memory clinics were retrospectively analyzed. The Revised Hasegawa Dementia Scale (HDS‐R) and Mini‐Mental State Examination (MMSE) were administered to all AD patients at the first visit and after approximately 12 months. We divided the patients into three groups according to scores at the first visit: mild, moderate and moderate‐to‐severe. We compared the scores at the first visit with those obtained after 12 months of anti‐AD drug and non‐pharmacological interventions. Results The HDS‐R score improved from 14.5 to 15.0, and the MMSE score improved from 18.8 to 19.1 after 12 months of intervention. Also, the HDS‐R and MMSE scores at the first visit were significantly associated with the annual change in the scores. Among the three groups, lower HDS‐R and MMSE scores at the first visit were associated with significantly greater annual improvement in the scores after 12 months of intervention. Conclusions Contrary to the prediction of Mendiondo's model, mild or moderate AD progressed more rapidly than moderate‐to‐severe AD under pharmacological and non‐pharmacological interventions. Geriatr Gerontol Int 2020; 20: 324–328.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Medical interventions suppressed progression of advanced Alzheimer's disease more than mild Alzheimer's disease

Honjo¹,

Ide

Takechi

2020

Geriatrics Gerontology Int

View full text Add to dashboard Cite

show abstract

“…The primary symptoms of AD are memory disturbance and disorientation, but people with AD often offer alternative explanations for such symptoms, which can prevent family members from recognising these as symptoms of AD. 8,9 Also, most people with symptoms are averse to taking a cognitive screening test because it can be difficult to accept any resulting diagnosis of cognitive disease. 9 The Hasegawa Dementia Scale-Revised (HDS-R) and Mini-Mental State Examination (MMSE) are commonly used to screen for cognitive disease in Japan.…”

Section: Introductionmentioning

confidence: 99%

Japanese Old Stories Cognitive Scale: a screening test to detect cognitive disease and prompt visiting a memory clinic

Honjo¹,

Takechi

2019

Psychogeriatrics

View full text Add to dashboard Cite

Background Early detection and diagnosis is critical in enhancing treatment outcomes for those with cognitive disease. However, most Japanese patients are averse to visiting mental health clinics or taking cognitive screening examinations. A new simple screening test is needed that is acceptable to patients and encourages them to visit a memory clinic if indicated. Methods We developed a brief screening examination, consisting of four common Japanese old stories, for detection of cognitive disease. A total of 311 patients at three outpatient memory clinics completed the screening test, responding to a 10‐question, fill‐in‐the‐blanks assessment. Questions were read aloud to patients with visual impairment, and we transcribed the spoken responses of patients who were physically incapable of writing. The Hasegawa Dementia Scale‐Revised (HDS‐R) and Mini‐Mental State Examination (MMSE) were administered at the same time. Results Using the developed Japanese Old Stories Cognitive Scale (JOSS), we found significant differences between dementia and control or mild cognitive impairment (MCI) groups. The JOSS was less affected by education level than the HDS‐R or MMSE, possibly because Japanese old stories are usually learned from family members during preschool years. The JOSS may be able to detect remote memory disturbance in addition to other cognitive dysfunctions. Conclusions Most patients with AD, even in advanced stages, are averse to visiting a memory clinic because it can be difficult to accept any resulting diagnosis of cognitive disease. JOSS is a quick and simple screening tool to gather evidence of cognitive dysfunction and prompt a referral to a memory clinic. Patients with cognitive disease found the JOSS acceptable, and its high specificity could be useful in encouraging patients to visit already‐crowded memory clinics for formal diagnosis and intervention.

show abstract

Brief Informant Interviews to Screen for Dementia: The AD8 and Quick Dementia Rating System

Galvin

Goodyear

2017

Cognitive Screening Instruments

View full text Add to dashboard Cite

Early symptoms of Alzheimer's disease in Japan and Taiwan

Cited by 11 publications

References 27 publications

Medical interventions suppressed progression of advanced Alzheimer's disease more than mild Alzheimer's disease

Medical interventions suppressed progression of advanced Alzheimer's disease more than mild Alzheimer's disease

Japanese Old Stories Cognitive Scale: a screening test to detect cognitive disease and prompt visiting a memory clinic

Brief Informant Interviews to Screen for Dementia: The AD8 and Quick Dementia Rating System

Contact Info

Product

Resources

About