Utility of Symptom Duration and C-Reactive Protein, White Blood Cell Count, and Absolute Neutrophil Count in the Evaluation of Pediatric Appendicitis

Davis, Joshua; Kasmire, Kathryn E.

doi:10.1016/j.jemermed.2020.10.040

Cited by 1 publication

(2 citation statements)

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“…[27,28] Recently, the conventional biomarkers, CRP, WBC, and Neu, were demonstrated to have inadequate characteristics to be used alone in diagnosing pediatric AA. [17] In the current study, consistent with the previous literature, the levels of WBC, CRP, and Neu in cases were significantly higher in the cases compared to controls (p<0.001 for each variable). Another biomarker suggested for AA diagnosis is PCT, which responds rapidly to severe and extensive bacterial infections.…”

Section: Discussionsupporting

confidence: 92%

“…[16] On the other hand, the low specificity of CRP for AA was recently underlined, and its limited utility as a diagnostic biomarker was emphasized. [10,17] Plasma levels of IL-6, CRP, and PCT were significantly different in children with AA compared to children with non-AA causes of abdominal pain. [18] The overall performance of IL-6 has been reported to be superior to PCT, especially regarding cost, sensitivity, and prediction of perforation.…”

Section: Introductionmentioning

confidence: 99%

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Akut Apandisitte Presepsin Performansı Üzerine Bir Pilot Çalışma: Prospektif Bir Vaka Kontrol Çalışması

TAŞAR>¹,

Fidancı²,

Bulut³

et al. 2022

Journal of Contemporary Medicine

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Aim: Diagnostic biomarkers are needed for pediatric acute appendicitis (AA). We hypothesized that presepsin (soluble CD14 subtype), a biomarker for sepsis, can also be used in pediatric AA and aimed to investigate its diagnostic value in those patients. Materials and Methods: This prospective case-control study was conducted on children admitted to the Pediatric Emergency Department with suspected acute appendicitis. Serum levels of interleukin-6, and presepsin were statistically analyzed for their diagnostic values. Results: No remarkable demographic differences were present between the 41 cases and 47 controls. Clinical and routine laboratory findings were significantly positive for acute appendicitis in the cases compared to controls. ROC analysis indicated an AUC for presepsin as 0.999 (CI 95%: 0.890-0.993) and for interleukin-6 as 0.963 (CI 95%:0.949-1.000). The best cut-off point value for presepsin was at 739 pg/ml, corresponding to a sensitivity of 97.56% and a specificity of 100%. The best cut-off point value for interleukin-6 was at 19 pg/ml, corresponding to a sensitivity of 97.56% and a specificity of 90.32%. Conclusions: Our study results indicate that presepsin can be considered a biomarker for diagnosing appendicitis in pediatric cases. Future studies might better include the combination with other biomarkers in pediatric cases.

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Section: Discussionsupporting

confidence: 92%