Utility of routine haematological parameters and infectious biomarkers to assess the disease severity in COVID-19 positive patients, analysis and early trend from India

Singh, Satbir; Singh, Pratima; Kelkar, Abhimanyu

doi:10.21203/rs.3.rs-40378/v1

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…They suggested total leukocyte count of 8100/cumm has sensitivity 91%, specificity 62.5% and NLR ratio of 6.9 has sensitivity 91.7%, specificity 87.5% and may assist in triaging patient requiring ICU care and deciding on intervention. 14 Zhang et al studied the clinical characteristics of 82 cases of death due to COVID-19 and most of the findings are in line with the present results. The researchers noted increased incidence of mortality in male subjects (66%) and more than half of the subjects who died were >60 yrs of age.…”

Section: Discussionsupporting

confidence: 89%

Clinical profile and outcome of elderly COVID-19 patients

2021

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Background: Emerging and reemerging infectious disease have plagued mankind and have been potential killer since historic times. The current pandemic of COVID-19 is the latest crisis that has challenged leadership and health infrastructure globally. Since, elderly are more susceptible, understanding risk factor and clinical feature in them is critically important to improve the outcome and efficacy of treatment.Methods: The prospective study included 1187 patients, aged ≥65 years diagnosed with COVID-19. Necessary record like demographic data, comorbidities and clinical features were collected. Relevant laboratory investigation done. Patients were grouped as survival and death. Different parameters were compared using t-test for continuous variables and Chi-square test for categorical data. Receiver operating curve (ROC) drawn using SPSS software.Results: Out of 1187 elderly people,316 (26%) have succumbed to death. Mortality was more in Male (68.7%). Fever (42%), cough (33.2%), dyspnea (26.9%) were the major symptom. Among patient who succumbed to death 45.9% people had diabetes with hypertension, 15.2% had only diabetes, 17.1% had only hypertension, 12.3% had chronic kidney disease and 15.56% had IHD. ROC curve drawn for TLC (AUC=0.72), NLR ratio (AUC=0.844), LDH (AUC=0.842), D-dimer (AUC=0.851), CRP (AUC=0.82), ferritin (AUC=0.823) which were statistically significant as predictor of disease outcome. D-dimer at cut-off 1 mcg/ml has specificity 89% and sensitivity 76% which is highest among the parameter, followed by NLR ratio at 6.9 has specificity (82%), sensitivity (73%).Conclusions: D-dimer of 1 mcg/ml, NLR ratio of 6.9 may assist in triaging patient requiring ICU care and deciding intervention. Also, elderly with multiple comorbidity should be treated aggressively, so that chance of survival can be increased.

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Section: Discussionsupporting

confidence: 89%

Clinical profile and outcome of elderly COVID-19 patients

2021

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“…However, there are only few studies that have come up so far regarding the usefulness of these biomarkers in COVID-19 infection. [ 7 8 ] Hence, this retrospective study was conducted to understand the use of these COVID-19 biomarkers in disease prognostication and correlation between these markers and clinical severity of the disease and outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…[ 21 ] There are hypotheses that neutrophil extracellular traps released by neutrophils contribute to organ damage and death in COVID-19 patients. [ 7 ] Fox et al . and Yao et al .…”

Section: Discussionmentioning

confidence: 99%

Utility of various inflammatory markers in predicting outcomes of hospitalized patients with COVID-19 pneumonia

et al. 2021

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Aim: The aim of the study is to study the utility of various inflammatory markers in predicting outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia. Primary Objective: The primary objective of the study is to analyze the correlation between various inflammatory markers and in-hospital mortality. Secondary Objectives: The secondary objective of the study is to assess the correlation between the inflammatory markers and clinical category of patients, and other outcomes such as length of hospital stay and need for invasive ventilation. Methods: A retrospective cross-sectional observational study was done in 221 hospitalized patients who were diagnosed with COVID-19 pneumonia in a tertiary care hospital in South India from May 2020 to July 2020. Clinical and laboratory data of patients diagnosed with COVID-19 pneumonia were collected. This included epidemiological data, clinical data, laboratory parameter (neutrophil: lymphocyte [N: L] ratio, C-reactive protein [CRP], ferritin, interleukin-6 [IL-6], lactate dehydrogenase, D-dimer, and procalcitonin), treatment details, and outcomes. Results: IL-6 levels >60.5 pg/mL and D-dimer levels >0.5 mcg/mL predicted in-hospital mortality with sensitivities of 80% and 76.7%, respectively. N: L ratio and CRP levels had good correlation with the need for oxygen supplementation and/or invasive ventilation. Conclusions: Judicious use of COVID-19 biomarkers could help in disease prognostication and thereby provide guidance to devise appropriate management strategies.

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“…These results are in concordance with the findings of other researchers. [ 13 14 15 16 17 18 19 20 21 22 23 24 25 ] Waris et al . [ 26 ] also demonstrated similar results except that they did not find a significant association between disease severity and lymphocytopenia ( P value = 0.28).…”

Section: Discussionmentioning

confidence: 99%

“…Singh et al . [ 18 ] observed CRP and LDH to be higher in severely ill patients but no correlation between serum ferritin and disease progression. CRP is an inflammatory marker, which was highly correlated with cardiac injury, acute respiratory distress syndrome and even death.…”

Section: Discussionmentioning

confidence: 99%

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

Sana¹,

Malviya²

2022

Journal of Family Medicine and Primary Care

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Background and Objectives: India has emerged as the second worst hit nation by the Coronavirus pandemic in terms of total number of cases. Our data on hematological and inflammatory markers associated with COVID-19 is very limited. This study was conducted to assess the utility of various biomarkers in identifying severe disease. Materials and Methods: All confirmed cases of COVID-19 admitted in our tertiary care centre from 1 st March 2021 to 31 st March 2021 were enrolled in the study. They were categorized into severe and non-severe disease categories based on pre-decided criteria. Their complete blood count parameters, D-dimer levels, serum C-reactive protein (CRP), ferritin and Lactate dehydrogenase (LDH) values were retrieved. Statistical Analysis: All parameters were expressed as Mean ± Standard deviation for the two groups of patients. Student's t -test was used to test significance of the above markers between severe and non- severe disease. ( P value < 0.05 was taken as statistically significant). Results: A total of 150 COVID RT-PCR positive patients were evaluated. The patients with higher Absolute Neutrophil Count (ANC), Neutrophil to lymphocyte Ratio (NLR), Platelet to lymphocyte ratio (PLR), D-dimer levels and raised serum CRP, LDH, ferritin along with lymphocytopenia were associated with severe disease ( P < 0.05). Hemoglobin, total leucocyte count and platelet count showed no correlation with disease severity. Conclusion: These biomarkers associated with disease severity especially NLR, PLR, D-dimer and serum CRP levels could be used to triage patients at the time of admission thereby identifying those requiring intensive care and enabling optimal resource utilization.

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Utility of routine haematological parameters and infectious biomarkers to assess the disease severity in COVID-19 positive patients, analysis and early trend from India

Cited by 6 publications

References 16 publications

Clinical profile and outcome of elderly COVID-19 patients

Clinical profile and outcome of elderly COVID-19 patients

Utility of various inflammatory markers in predicting outcomes of hospitalized patients with COVID-19 pneumonia

Identification of hematological and inflammatory parameters associated with disease severity in hospitalized patients of COVID-19

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