Utility of quantitative susceptibility mapping and diffusion kurtosis imaging in the diagnosis of early Parkinson’s disease

Tan, Samantha; Hartono, Septian; Welton, Thomas; Ann, Chu Ning; Lim, Soo Lee; Koh, Tong San; Li, Huihua; Setiawan, Fiona; Ng, Samuel Yong‐Ern; Chia, Nicole Shuang Yu; Liu, Saifeng; Haacke, E. Mark; Tan, Eng King; Tan, Louis C.S.; Chan, Ling Ling

doi:10.1016/j.nicl.2021.102831

Cited by 13 publications

(8 citation statements)

References 51 publications

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“… When PD have reduced serum ceruloplasmin, more widespread iron accumulation is expected, including PUT. Tan et al (2021) [ 88 ] 3 T/32 QSM PD: 47/HC: 16 ↑ χ value significantly in PD in PUT. ↑ MD in PD in lateral SN, PUT, and caudate, regions with the lowest χ value.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies have reported changes in the distribution of χ in the PUT region of the brain under various conditions. These studies reported alterations in χ distribution in the PUT for MSA-P, increased PUT R2* values in PD patients compared to HCs [ 85 ], significant iron accumulation in PUT in PD patients with low serum ceruloplasmin (PD-LC) compared to HCs [ 87 ], and significantly increased χ value in PD patients with PUT [ 88 ]. Furthermore, Guan et al (2021) [ 87 ] found that increased iron accumulation in the PUT remained significantly different between PD patients with normal serum ceruloplasmin and PD-LC, and this accumulation was negatively correlated with serum ceruloplasmin in all patients with PD.…”

Section: Resultsmentioning

confidence: 99%

“…One study found an increase in mean diffusivity (MD) in certain areas of the brain, such as the lateral SN, PUT, and caudate regions, with the lowest χ value in patients with PD [ 88 ]. The use of both QSM and diffusion kurtosis imaging (DKI) provided a more comprehensive understanding of the changes in iron deposition and microstructure in PD pathophysiology [ 88 ].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Mohammadi,

Ghaderi

2024

Heliyon

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Mohammadi,

Ghaderi

2024

Heliyon

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“…In the SN itself, we did not detect a significant change over time, although MK in the SN is more difficult to accurately measure because of its small size, irregular shape, and susceptibility to imaging artefacts from iron deposition and geometric distortion [ 39 ]. These can lead to partial volume effects, imprecise segmentation, and reduced signal-to-noise ratio.…”

Section: Discussionmentioning

confidence: 99%

Microstructure of Brain Nuclei in Early Parkinson’s Disease: Longitudinal Diffusion Kurtosis Imaging

Welton

Hartono

Shih

et al. 2023

JPD

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Background: Diffusion kurtosis imaging provides in vivo measurement of microstructural tissue characteristics and could help guide management of Parkinson’s disease. Objective: To investigate longitudinal diffusion kurtosis imaging changes on magnetic resonance imaging in the deep grey nuclei in people with early Parkinson’s disease over two years, and whether they correlate with disease progression. Methods: We conducted a longitudinal case-control study of early Parkinson’s disease. 262 people (Parkinson’s disease: n = 185, aged 67.5±9.1 years; 43% female; healthy controls: n = 77, aged 66.6±8.1 years; 53% female) underwent diffusion kurtosis imaging and clinical assessment at baseline and two-year timepoints. We automatically segmented five nuclei, comparing the mean kurtosis and other diffusion kurtosis imaging indices between groups and over time using repeated-measures analysis of variance, and Pearson correlation with the two-year change in Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III. Results: At baseline, mean kurtosis was higher in Parkinson’s disease than controls in the substantia nigra, putamen, thalamus and globus pallidus when adjusting for age, sex, and levodopa equivalent daily dose (p < 0.027). These differences grew over two years, with mean kurtosis increasing for the Parkinson’s disease group while remaining stable for the control group; evident in significant “group ×time” interaction effects for the putamen, thalamus and globus pallidus ( η p 2 = 0.08–0.11, p < 0.015). However, we did not detect significant correlations between increasing mean kurtosis and declining motor function in the Parkinson’s disease group. Conclusion: Diffusion kurtosis imaging of specific grey matter structures shows abnormal microstructure in PD at baseline and abnormal progression in PD over two years.

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“…In terms of observation of pathological features, MRI techniques have become part of the routine diagnostic process to differentiate Parkinson’s disease from secondary or atypical Parkinson’s syndrome due to the high specificity of some MRI features for atypical Parkinson’s syndrome. Novel MRI has been developed with potential as a biomarker for early or even prodromal Parkinson’s disease [ 60 ], including neuromelanin imaging (NMI) for analysis of nigrostriatal area, contrast ratio and volume [ 61 ] and quantitative susceptibility mapping (QSM), for quantification of iron deposition in the substantia nigra [ 62 ]. Dementia with Lewy bodies (DLB) and Alzheimer’s disease overlap in clinical features and this distinction is often challenging.…”

Section: Radionuclide Imaging For Assessing Intracerebral Pharmacokin...mentioning

confidence: 99%

Imaging Technologies for Cerebral Pharmacokinetic Studies: Progress and Perspectives

2022

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Pharmacokinetic assessment of drug disposition processes in vivo is critical in predicting pharmacodynamics and toxicology to reduce the risk of inappropriate drug development. The blood–brain barrier (BBB), a special physiological structure in brain tissue, hinders the entry of targeted drugs into the central nervous system (CNS), making the drug concentrations in target tissue correlate poorly with the blood drug concentrations. Additionally, once non-CNS drugs act directly on the fragile and important brain tissue, they may produce extra-therapeutic effects that may impair CNS function. Thus, an intracerebral pharmacokinetic study was developed to reflect the disposition and course of action of drugs following intracerebral absorption. Through an increasing understanding of the fine structure in the brain and the rapid development of analytical techniques, cerebral pharmacokinetic techniques have developed into non-invasive imaging techniques. Through non-invasive imaging techniques, molecules can be tracked and visualized in the entire BBB, visualizing how they enter the BBB, allowing quantitative tools to be combined with the imaging system to derive reliable pharmacokinetic profiles. The advent of imaging-based pharmacokinetic techniques in the brain has made the field of intracerebral pharmacokinetics more complete and reliable, paving the way for elucidating the dynamics of drug action in the brain and predicting its course. The paper reviews the development and application of imaging technologies for cerebral pharmacokinetic study, represented by optical imaging, radiographic autoradiography, radionuclide imaging and mass spectrometry imaging, and objectively evaluates the advantages and limitations of these methods for predicting the pharmacodynamic and toxic effects of drugs in brain tissues.

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Utility of quantitative susceptibility mapping and diffusion kurtosis imaging in the diagnosis of early Parkinson’s disease

Cited by 13 publications

References 51 publications

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Parkinson's disease and Parkinsonism syndromes: Evaluating iron deposition in the putamen using magnetic susceptibility MRI techniques - A systematic review and literature analysis

Microstructure of Brain Nuclei in Early Parkinson’s Disease: Longitudinal Diffusion Kurtosis Imaging

Imaging Technologies for Cerebral Pharmacokinetic Studies: Progress and Perspectives

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