Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Okuturlar, Yıldız; Günaldı, Meral; Tiken, Elif Eda; Öztosun, Buğra; İnan, Yeşim Özdem; Ercan, Tarık; Tuna, Savas; Kaya, Ali; Harmankaya, Özlem; Kumbasar, Abdülbaki

doi:10.7314/apjcp.2015.16.6.2409

Cited by 53 publications

(62 citation statements)

References 25 publications

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“…In healthy individuals, MPV and PDW values are counterbalancing each other. But previous studies of the MPV and PDW showed that this collateral distribution could change in various types of cancer (Okuturlar et al, 2015;Ozaksit et al, 2015). For example, a study of lung cancer patients reported that the MPV was lower and that the PDW was higher (Oncel et al, 2015), similarly to that what was found in the present study.…”

Section: Discussionsupporting

confidence: 76%

“…For example, a study of lung cancer patients reported that the MPV was lower and that the PDW was higher (Oncel et al, 2015), similarly to that what was found in the present study. Also, other studies found no statistically significant differences between the PDW value in neoplastic adnexal mass and breast cancer and PDW values in a control group (Ma et al, 2014;Okuturlar et al, 2015). The PDW value in non small cell lung cancer was reported to be lower than that of a control group (Inagaki et al, 2014).…”

Section: Discussionmentioning

confidence: 93%

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Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

Arıcıgil

Dündar

Yücel³

et al. 2017

Prague Med. Rep.

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Abstract:This study aimes to evaluate platelet and leucocyte indicators, such as the mean platelet volume, platelet distribution width, plateletcrit, white blood cell count, neutrophil to lymphocyte ratio in nasopharyngeal cancer patients and also to evaluate the relationship between these indicators and nasopharyngeal cancer with distant metastasis. The medical records of 118 patients diagnosed with nasopharyngeal cancer in our hospital between January 2006 and August 2015 were reviewed. The nasopharyngeal cancer group was further sub grouped according to the presence or absence of distant metastasis and TNM (tumour -T, node -N, metastasis -M) classification. A control group consisted of 120 healthy patients. The platelet and leucocyte values at the time of the initial diagnosis were recorded. Neutrophil to lymphocyte ratio and platelet distribution width values were significantly higher in the nasopharyngeal cancer group. But only platelet distribution width values were significantly higher in the nasopharyngeal cancer group with distant metastasis compared to the nasopharyngeal cancer group without distant metastasis. Neutrophil to lymphocyte ratio and platelet distribution width values may increase in nasopharyngeal cancer. But only the platelet distribution width values may give us an idea about the distant metastasis in nasopharyngeal cancer.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 93%

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

Arıcıgil

Dündar

Yücel³

et al. 2017

Prague Med. Rep.

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“…PDW has been noted to be increased in gastric cancer and lung cancer 19, 20 . In contrast, PDW is decreased in thyroid cancer and breast cancer 21, 22 . The conflicting data maybe due to small sample sizes, failure to rule out confounding factors, different tumor type, and selected populations.…”

Section: Discussionmentioning

confidence: 87%

Platelet distribution width correlates with prognosis of non-small cell lung cancer

Cui

Liu

et al. 2017

Sci Rep

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Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) and platelet distribution width (PDW) are commonly used platelet parameters from routine blood test. The aim of the present study was to investigate the correlation between platelet indices and prognosis in patients with non-small cell lung cancer (NSCLC). A total of 270 patients who were diagnosed with NSCLC between January 2009 and December 2009 were retrospectively analyzed. Patients’ characteristics and hematologic tests data at initial diagnosis were collected. The overall survival rate was estimated using Kaplan-Meier method. The prognostic analysis was carried out with univariate and multivariate Cox regressions model. Reduced PDW was significantly correlated with T stage, N stage, TNM stage, and histological type of the disease. Moreover, survival analysis showed that the overall survival of patients with PDW ≥ 16.3% was significantly longer than that of those with PDW < 16.3% (P < 0.001). In multivariate Cox regression model, age, sex, TNM stage, and PDW were identified as independent prognostic factors for overall survival (for PDW, P < 0.001). In conclusion, reduced PDW is an unfavorable predictive factor of NSCLC patient survival. Further studies are warranted.

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“…PLR is reported to be correlated with worse outcomes in different malignant tumors such as colorectal cancer [6], lung cancer [7, 8], and gastric cancer [9, 10]. Growing evidence also showed that PLR could provide implications for therapeutic modalities selection and prognosis prediction for breast cancer patients [11–13]. However, the association between PLR and breast cancer prognosis is controversial because relevant studies present different results [14–16].…”

Section: Introductionmentioning

confidence: 99%

Platelet-lymphocyte ratio acts as an indicator of poor prognosis in patients with breast cancer

et al. 2016

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Platelet-lymphocyte ratio (PLR) is a hematological parameter which is investigated as a biomarker for prognosis in patients with breast cancer. Due to the controversial results from previous studies, we performed a meta-analysis. Databases of PubMed, Embase and Web of Science were searched to identify eligible studies. STATA version 12.0 was used for statistical analysis. Seven studies with 3,741 patients were ultimately included in this meta-analysis. High PLR was associated with poor overall survival (OS) (HR = 1.55, 95% CI = 1.07–2.25, p = 0.022) and disease-free survival (DFS) (HR = 1.73, 95% CI = 1.3-2.3, p < 0.001) in breast cancer patients. Subgroup analyses disclosed that elevated PLR could predict worse OS in Asian populations and poor DFS in both Asian and non-Asian patients. In addition, PLR remains a significant prognostic marker for OS in patients receiving systemic treatment (HR = 1.78, 95% CI = 1.06–2.99, p = 0.03) and patients receiving chemotherapy (HR = 2.82, 95% CI = 1.09–7.26, p = 0.032). High PLR also indicates poor DFS in patients who receive chemotherapy (HR = 2.6, 95% CI = 1.47–4.61, p = 0.001), surgery (HR = 1.8, 95% CI = 1.12–2.89, p = 0.016) and systemic treatment (HR = 2.03, 95% CI = 1.03–4.01, p = 0.042). Moreover, PLR was also in association with HER-2 positivity (OR = 1.48, 95% CI = 1.2–1.83, p < 0.001). In conclusion, this meta-analysis revealed that PLR could serve as an indicator of poor prognosis in patients with breast cancer.

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Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk

Cited by 53 publications

References 25 publications

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

Can Platelet and Leukocyte Indicators Give Us an Idea about Distant Metastasis in Nasopharyngeal Cancer?

Platelet distribution width correlates with prognosis of non-small cell lung cancer

Platelet-lymphocyte ratio acts as an indicator of poor prognosis in patients with breast cancer

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