Utility of Immunofluorescence of Urine Sediment for Identifying Patients With Renal Disease Due to Monoclonal Gammopathies

Fogazzi, Giovanni B.; Pozzi, Claudio; Passerini, Patrizia; Simonini, Paola; Locatelli, Francesco; Ponticelli, Claudio

doi:10.1016/s0272-6386(12)81131-0

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Myeloma Light Chain Crystalline Nephropathy1

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“…More sophisticated urine testing has confirmed that LCs can be seen in the urine. Immunofluorescence (IF) staining (anti-sera to LC immunoglobulins) of the urine sediment was used to identify monoclonal LCs in patients with kidney disease and various monoclonal gammopathies [ 6 ]. Urinary casts and other various shaped particles were demonstrated in the urine of 20 out of 27 patients with monoclonal disease and 0 out of 25 patients with non-monoclonal kidney disease.…”

Section: Myeloma Light Chain Crystalline Nephropathymentioning

confidence: 99%