Clinical and laboratory diagnosis of acute renal failure

Barry, Daniel W.

doi:10.1016/j.bpa.2003.09.009

Cited by 30 publications

(12 citation statements)

References 80 publications

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“…A decreased diuresis, particularly in critically ill patients, might be one of the first signs that draw attention to a decreased renal function. However, this criterion does not exclude prerenal factors, and most cases of AKI that are encountered in contemporary clinical practice are nonoliguric in nature (31). In addition, urine output is influenced by the eventual administration of diuretics.…”

Section: Defining Patients At Risk For Acute Renal Injurymentioning

confidence: 99%

Defining Acute Renal Failure

Biesen

Vanholder²,

Lameire³

2006

Clinical Journal of the American Society of Nephrology

155

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The introduction of the RIFLE classification has increased the conceptual understanding of the acute kidney injury (AKI) syndrome, and this classification has been successfully tested in a number of clinical studies. This review discusses the strengths and weaknesses of the RIFLE classification and suggests additional parameters to broaden future definitions of AKI. These definitions should not only focus on kidney function alone, but also include parameters describing the origin of the patient, the most important causal factors responsible for AKI and information on the pre-existing kidney function. This more complete definition should lead to a decrease in the variability of the results of epidemiological studies and of future clinical trials in AKI populations.

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Section: Defining Patients At Risk For Acute Renal Injurymentioning

confidence: 99%

Defining Acute Renal Failure

Biesen

Vanholder²,

Lameire³

2006

Clinical Journal of the American Society of Nephrology

155

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“…icroscopic examination of the urine sediment plays an important role in the evaluation of patients with kidney injury (1)(2)(3)(4)(5). Although many nephrologists evaluate the urine sediment themselves, some practitioners have delegated urine sediment interpretation to their local clinical laboratory for interpretation by trained technologists (1).…”

mentioning

confidence: 99%

Interobserver Reliability of Urine Sediment Interpretation

Wald¹,

Bell²,

Nisenbaum³

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background and objectives: Urine sediment interpretation is frequently used in the evaluation of patients with kidney disease. There has been no systematic evaluation of the reliability of this diagnostic maneuver.Design, setting, participants, & measurements: Digital photographs of urine sediment images were acquired from 165 consecutive patients being evaluated by the nephrology consultation service at a tertiary care hospital. Urine sediment images of 100 patients were randomly selected; 86 patients had images that were deemed to be of sufficient quality, and one image per patient was chosen for inclusion in an internet-based questionnaire.

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“…6 Therefore, noninvasive early biomarkers that predict subclinical renal damage are necessary. The most promising biomarkers are human kidney injury molecule-1 (KIM-1), liver-type fatty-acid binding protein (L-FABP), N-acetyl-b-D-glucosaminidase A (NAG), and neutrophil gelatinase-associated lipocalin (NGAL).…”

Section: Introductionmentioning

confidence: 99%

Urinary levels of early kidney injury molecules in children with vitamin B12 deficiency

2016

Arch Argent Pediat

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The aim of this study was to investigate urine early kidney injury molecules, including human kidney injury molecule-1 (KIM-1), liver-type fatty-acid binding protein (L-FABP), N-acetyl-b-D-glucosaminidase A (NAG), and neutrophil gelatinase-associated lipocalin (NGAL) in children with vitamin B12 (cobalamin) deficiency (CD). Twelve children with vitamin B12 deficiency and 20 healthy matched controls were included. Hematologic parameters, serum urea, creatinine (Cr), electrolytes, B12 and folate levels were recorded. Estimated glomerular filtration rate (eGFR) was calculated. Urine protein, electrolytes, and urinary early markers were measured. Patients with CD had significantly higher urine electrolyte/Cr ratios (p <0.05). Significantly higher urinary KIM-1/Cr, L-FABP/Cr, NAG/Cr and NGAL/Cr were found in CD group (p <0.05). Significant negative correlations were found between levels of serum B12 and urinary markers in the patients (p <0.05). Increased urinary kidney injury molecules and electrolytes in children with B12 deficiency suggest a possible subclinical renal dysfunction, which cannot be determined by conventional kidney function tests.

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Clinical and laboratory diagnosis of acute renal failure

Cited by 30 publications

References 80 publications

Defining Acute Renal Failure

Defining Acute Renal Failure

Interobserver Reliability of Urine Sediment Interpretation

Urinary levels of early kidney injury molecules in children with vitamin B12 deficiency

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