Utility of haematological parameters and C‐reactive protein in the detection of neonatal sepsis

Manucha, Varsha; Rusia, Usha; Sikka, Meera; Faridi, M. M. A.; Madan, N

doi:10.1046/j.1440-1754.2002.00018.x

Cited by 74 publications

(67 citation statements)

References 26 publications

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“…[14] Lateonset sepsis syndrome occurs at 7-90 days of life and is acquired from the care-giving environment, prolonged hospital stay and invasive interventions. [15] However, the major concern in neonatal sepsis is its nonspecific presentation, sometimes the rapid progression of sepsis. Therefore, a high index of suspicion is important in the diagnosis and treatment of neonatal infection, but it is difficult to establish a diagnosis based on clinical picture alone.…”

Section: Discussionmentioning

confidence: 99%

Haematological Scoring System (Hss) in Early Diagnosis of Neonatal Sepsis: A Study From Tertiary Care Hospital From North East India

Dutta¹,

Medhi²,

Hazarika³

2016

jemds

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BACKGROUNDNeonatal sepsis is defined as a clinical syndrome of bacteraemia with systemic signs and symptoms of infection in the first 4 weeks of life. Timely diagnosis of sepsis in neonates is critical as the illness can be rapidly progressive and in some instances fatal. The definitive diagnosis of septicaemia is made by a positive blood culture, which requires a minimum of 48-72 hours with a positive result in only 10-60% of cases. Haematological parameter can be evaluated for the early diagnosis of neonatal bacterial infection.

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Section: Discussionmentioning

confidence: 99%

Haematological Scoring System (Hss) in Early Diagnosis of Neonatal Sepsis: A Study From Tertiary Care Hospital From North East India

Dutta¹,

Medhi²,

Hazarika³

2016

jemds

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“…Thorough general and local-system clinical examinations were performed, including cardiovascular, chest, neurological, abdominal, and skin evaluations. The laboratory investigations included a complete blood count (total and differential), µESR by spectrometric analysis, and CRP using the latex agglutination method (13). As an initial step in the sepsis workup, blood was drawn into blood culture bottles (Egyptian Diagnostic Media) before initiation of antibiotic therapy and under aseptic techniques according to standard microbiological methods (14).…”

Section: Methodsmentioning

confidence: 99%

Apoptotic Changes in the Early Diagnosis and Severity Determination of Neonatal Sepsis

Barseem

Helwa

2016

Iran J Pediatr

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Objectives: The aim of this study was to assess the presence of DNA damage in full-term newborns with neonatal sepsis. Methods: Sixty neonates with early onset neonatal sepsis and 45 apparently healthy controls were enrolled in the study. Screening of neonates was done using a modified clinical sepsis score and hematological scoring system, adjusted to the results of blood culture and screening tests. Complete blood count, C-reactive protein (CRP), and DNA studies were done. Results: Sepsis was likely in 41 (68.3%) patients with scores of 3 or 4 and CRP levels of 12 -48 mg/L. Sepsis was very likely in 19 (31.7%) patients with scores of ≥ 5 and CRP of 48 -96 mg/L. Sepsis was unlikely in all controls with scores of ≤ 2. The mean neutrophil count was 9700 ± 4600/µL in patients and 4230 ± 1400/µL in controls. The higher the total polymorphonuclear count and CRP level, the more severe was the sepsis. Twenty-six of 60 (43.3%) sepsis patients and 5 of 45 controls (11%) had DNA damage. There was a highly significant negative correlation between DNA damage, blood culture results, and CRP levels. Conclusions: DNA damage, demonstrated by clinical and laboratory evidence with a combination of blood cultures, CRP, and hematological scoring system results, can be used as an indicator of both the immune status of the neonate and the severity of the sepsis.

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“…35 In the present study, neonates who were clinically suspected of sepsis, their WBC counts was normal, high or low as 95.3%, 2.8% or 1.9%, respectively. Among WBC count changes, neutropenia is the most reliable predictor of neonatal sepsis; it reflects the severity of sepsis and represents depletion of neutrophil reserves, and requires specific therapeutic measures for management.…”

Section: Discussionmentioning

confidence: 43%

Evaluation of hypoglycemic status and causative factors in neonatal sepsis

Islam

Aklima

Yesmin

et al. 2017

Int J Contemp Pediatr

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Background: Very few studies have been reported on hypoglycemic status, hematological parameters and causative organisms of neonatal sepsis in different regions of Bangladesh. Hence, present study was conducted in the Chittagong city of Bangladesh.Methods: The study was conducted on 106 neonates (0 to 28 days of age) in Chattagam Maa-Shishu O General Hospital, Bangladesh. The questionnaire was developed to get relevant information of the neonates. Blood from neonates were subjected to routine investigations like blood glucose, CRP, hematological parameters, blood culture and bacterial identification.Results: Among 106 neonates with sepsis, 68 presented early onset neonatal sepsis (EONS) and 38 presented late onset neonatal sepsis (LONS). Fifty-one neonates had low birth weight (2500 g or less), 18 had very low birth weight (1500 g or less) and 22 were preterm. The most prevalent clinical features were reluctant to feed (56), hyperthermia (31) and hypotonia (22). Thirty-three neonates had neutropenia (<54%) and 62 had higher neutrophil count (>62%). Biochemical analysis showed 52 had higher C-reactive protein levels. Investigation of hypoglycemic status revealed that there were different types of neonatal sepsis, i.e. 77 neonates were hypoglycemic (<45 gm/dl), and among them EONS and LONS were 59 and 18, respectively. Thirty-three neonates had positive blood culture for bacteria. Among them, Klebsiella spp. accounted for 10 of the total isolates followed by Acinetobacter spp. 8. The Gram-positive and negative bacteria were found in 7 and 26, respectively.Conclusions: Hypoglycemia was associated with neonatal sepsis as an exacerbating factor.

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Utility of haematological parameters and C‐reactive protein in the detection of neonatal sepsis

Cited by 74 publications

References 26 publications

Haematological Scoring System (Hss) in Early Diagnosis of Neonatal Sepsis: A Study From Tertiary Care Hospital From North East India

Haematological Scoring System (Hss) in Early Diagnosis of Neonatal Sepsis: A Study From Tertiary Care Hospital From North East India

Apoptotic Changes in the Early Diagnosis and Severity Determination of Neonatal Sepsis

Evaluation of hypoglycemic status and causative factors in neonatal sepsis

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