Utility of Frozen Section Pathology with Endometrial Pre-Malignant Lesions

Öz, Murat; Özgü, Emre; Elmas, Korkmaz; Bayramoǧlu, Hati̇ce; Erkaya, Salım; Güngör, Tayfun

doi:10.7314/apjcp.2014.15.15.6053

Cited by 6 publications

(4 citation statements)

References 30 publications

(34 reference statements)

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“…However, the present shows that frozen section is needed in particular for insufficient preoperative biopsy or ultrasonographically suspicious of malignancy but preoperatively benign biopsy patients. The procedure was also found as a reliable method to detect endometrial malignancy by other studies (20,23) especially in patients with premalignant preoperative biopsy results (8,24).…”

Section: Discussionmentioning

confidence: 65%

The Accuracy of an Intraoperative Frozen Section for Premalignant Endometrial Pathology

Bör

Akdeniz

Ceylan

et al. 2020

Gynecol Obstet Reprod Med

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OBJECTIVE: Abnormal uterine bleeding which is the most frequent complaint among pre- and postmenopausal women should be investigated to rule out endometrial cancer. An intra-operative frozen section can be taken to examine the suspicious of the malignancy. The study aims to investigate the accuracy of frozen section in suspicious of endometrial malignancy.STUDY DESIGN: Fifty patients with pre-malign endometrial pathology and malignant ultrasound characteristics were included in this study and their preoperative biopsy, frozen and postoperative pathological results were examined. RESULTS: The kappa coefficient between postoperative pathology and frozen section was 0.88 (p<0.05) and 95% confidence interval was (0.63-1.12). This indicates that the amount of agreement between the two tests was strong, thus the frozen section would be considered as a valid indicator of postoperative pathology results.CONCLUSIONS: Frozen section is a valuable method to investigate the suspicious of malignancy in endometrial pre-malign lesions.

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Section: Discussionmentioning

confidence: 65%

The Accuracy of an Intraoperative Frozen Section for Premalignant Endometrial Pathology

Bör

Akdeniz

Ceylan

et al. 2020

Gynecol Obstet Reprod Med

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“… Sensitivity and specificity results for each study are presented [ 13 , 16 , 20 , 24 , 46 , 52 , 53 , 54 , 55 , 56 , 58 ]. …”

Section: Figurementioning

confidence: 99%

“…Figure 2. Sensitivity and specificity results for each study are presented[13,16,20,24,46,[52][53][54][55][56]58].…”

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confidence: 99%

Accuracy of Frozen Section Biopsy in the Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis

Kopatsaris,

Apostolopoulou,

Tsakiridis

et al. 2024

Cancers

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The early and accurate diagnosis of endometrial cancer is of paramount importance for the survival of these patients. The aim of this study was to systematically appraise the available data regarding the accuracy of frozen section biopsy in diagnosing endometrial cancer. A thorough literature search was performed in PubMed/Medline, Scopus and the Cochrane Central Register of Controlled Trials databases from inception up to January 2023, with the use of specific, relevant key terms. A quality evaluation for each study was performed with the QUADAS-2 tool, whereas a bivariate random-effect model was performed to generate a summary receiver-operated curve. Heterogeneity was evaluated with Cochrane Q and Higgins’ I2 statistics. Subgroup analyses were performed for studies focused on atypical hyperplasia and those focused on endometrial cancer. The search yielded 47 studies, involving 7790 patients with endometrial cancer. Among them, only 11 could be included in the quantitative analysis. QUADAS-2 evaluation resulted in rather high quality among the included studies. Quantitative synthesis resulted in a pooled sensitivity of 0.863 and pooled specificity of 0.916. The AUC was 0.948, the Q statistic was 10.488 (10 df, p = 0.399) and Higgins’ I2 (4.655%) reported no significant heterogeneity. Subgroup analyses based on the diagnosis revealed a pooled sensitivity 0.886, specificity 0.862 and AUC 0.934 for endometrial cancer versus a sensitivity of 0.816, specificity of 0.962 and AUC 0.939 for atypical hyperplasia. Frozen section appears as a valid and reliable diagnostic tool for endometrial cancer. Its reliability seems to be even higher for the diagnosis of atypical hyperplasia. Therefore, this method may be considered in clinical practice and in settings with appropriate resources.

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“…Additionally approximately 60% of UPSC patients are diagnosed with greater than stage 1 disease (Slomovitz et al, 2003). Lymphatic drainage is an important way of tumor dissemination for endometrial cancers (Oz et al, 2014) and histology of UPSC is an independent predictor of postoperative adjuvant treatment in early stage endometrial cancer (Demiral et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Lympho-Vascular Space Invasion Indicates Advanced Disease for Uterine Papillary Serous Tumors Arising from Polyps

Ilker

Elmas²,

Ozgu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Uterine papillary serous tumors are rarely seen and behave aggressively. Our aim was to evaluate uterine papillary serous tumors arising from polyps. Materials and Methods: Clinicopathological data of patients with uterine serous cancer arising from a polyp at the Gynecological Oncology Department of Zekai Tahir Burak Women's Health Education and Research Hospital were reviewed retrospectively. Results: We analyzed patients according to FIGO 2009 staging system as stage 1A and higher than stage 1A (3 and 6, respectively). All the patients were postmenopausal. Mean CA-125, CA-19.9 and CA15.3 levels were elevated in higher than stage 1A group. However we did not find a statistical difference between age, parity, polyp size, CA-125, CA-15.3, CA-19.9 and CEA levels. Lympho-vascular space invasion (LVSI) showed predictivity for advanced disease (p=0.025). Conclusions: The histopathologic nature of uterine serous carcinoma is a unique entity. LVSI is a prognosticator for defining an advanced stage uterine papillary tumor.

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Utility of Frozen Section Pathology with Endometrial Pre-Malignant Lesions

Cited by 6 publications

References 30 publications

The Accuracy of an Intraoperative Frozen Section for Premalignant Endometrial Pathology

The Accuracy of an Intraoperative Frozen Section for Premalignant Endometrial Pathology

Accuracy of Frozen Section Biopsy in the Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis

Lympho-Vascular Space Invasion Indicates Advanced Disease for Uterine Papillary Serous Tumors Arising from Polyps

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